RECRUITING

Natural History of Stroke: Cause and Development

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to learn more about stroke and obtain information that may serve as the basis for future investigations. It will 1) establish a registry of patients with cerebrovascular disease (stroke); 2) characterize the natural history of acute stroke and transient ischemic attacks (TIA)-an interruption of blood flow to the brain that causes stroke symptoms for a short period of time); and 3) evaluate the data to generate ideas for future studies. Patients 18 years of age or older with suspected acute stroke or TIA may be eligible for this study. Subjects will be recruited from patients who present with stroke at the emergency department of Suburban Hospital in Bethesda, Maryland. The study will gather data collected from diagnostic and laboratory tests the patient undergoes as part of standard medical care, including findings of medical and neurological examinations and other tests. In addition, studies will be done for research purposes only to gather data about stroke and TIA. These may include the following: * Blood and urine tests not more than 2 tablespoons of blood will be drawn for various tests. * Electrocardiogram (EKG) (heart tracing)-electrodes placed on the chest wall detect the heartbeat and heart rhythm. * Computed tomography (CT) scan of the head-specialized X-rays are used to obtain images of the brain. * Magnetic resonance imaging (MRI) of the brain-a strong magnetic field and radio waves are used to produce images that provide information about the brain tissue and blood vessels. * Transcranial Doppler (TCD)-sound waves are used to image the arteries of the brain and neck. * Echocardiogram-sound waves are used to image the heart and evaluate heart function. Patients may be asked to return to Suburban Hospital for follow-up testing in 1, 3, and/or 12 months, when some of these tests may be repeated to assess changes over time

Official Title

Evaluation, Pathogenesis, and Treatment of Patients With or at Risk for Cerebrovascular Disease (A Natural History/Disease Pathogenesis Protocol)

Quick Facts

Study Start:2001-01-26
Study Completion:N/A
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT00009243

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 120 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Aged \>=18
  2. 2. Presented to participating study site (ED, ICU, or inpatient unit) with or at risk of acute stroke, TIA, or other disturbances of cerebrovascular circulation
  1. 1. Subjects with contraindication to MRI scanning will be excluded from any testing which involves the use of MRI. The contraindications include subjects with the following devices or conditions:
  2. * Central nervous system aneurysm clips
  3. * Implanted neural stimulator
  4. * Implanted cardiac pacemaker or defibrillator
  5. * Cochlear implant
  6. * Ocular foreign body (e.g. metal shavings)
  7. * Insulin pump
  8. * Metal shrapnel or bullet
  9. * Any implanted device that is incompatible with MRI
  10. 2. Pregnancy

Contacts and Locations

Study Contact

Nicole L Peterkin
CONTACT
(301) 435-2395
nicole.peterkin@nih.gov
Lawrence L Latour, Ph.D.
CONTACT
(301) 435-2395
latourl@ninds.nih.gov

Principal Investigator

Lawrence L Latour, Ph.D.
PRINCIPAL_INVESTIGATOR
National Institute of Neurological Disorders and Stroke (NINDS)

Study Locations (Sites)

Medstar Washington Hospital Center
Washington D.C., District of Columbia, 20010
United States
Suburban Hospital - Johns Hopkins Medicine
Bethesda, Maryland, 20814
United States
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
United States

Collaborators and Investigators

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

  • Lawrence L Latour, Ph.D., PRINCIPAL_INVESTIGATOR, National Institute of Neurological Disorders and Stroke (NINDS)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2001-01-26
Study Completion DateN/A

Study Record Updates

Study Start Date2001-01-26
Study Completion DateN/A

Terms related to this study

Keywords Provided by Researchers

  • Stroke
  • Natural History
  • MRI (Magnetic Resonance Imaging)
  • Magnetic Resonance Imaging
  • Acute Stroke
  • TIA

Additional Relevant MeSH Terms

  • Brain Disease
  • Ischemic Attack, Transient
  • Cerebrovascular Accident
  • Cerebrovascular Disorder
  • Vascular Diseases