RECRUITING

Genetic Basis of Immunodeficiency

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will examine the role of hereditary factors in different forms of severe combined immunodeficiency (SCID). Patients with immunodeficiencies may be eligible for this study. Candidates include: * Patients with diminished numbers of T cells or NK cells or both, or * Patients with normal T cell and NK cell numbers but diminished T cell, B cell, or NK cell function. Relatives of patients will also be studied. Participants will have blood samples collected for genetic analysis in studies related to SCID at the National Institutes of Health and other institutions.

Official Title

The Determination of Genetic Basis Of Immunodeficiency

Quick Facts

Study Start:2004-04-05
Study Completion:N/A
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT00055172

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:6 Months to 99 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients (index cases): 6 months of age and older
  2. * Siblings: 6 months of age and older
  3. * Non-sibling relatives (biological parent, aunt, uncle or grandparent): 18 years or older
  1. * Patients with a known diagnosis
  2. * Patients with a particular immunological phenotype that is not of interest to the research conducted under this study.
  3. * Pregnancy or lactation
  4. * Adults with current decisional impairment

Contacts and Locations

Study Contact

Warren J Leonard, M.D.
CONTACT
(301) 496-0098
wl2w@nih.gov

Principal Investigator

Warren J Leonard, M.D.
PRINCIPAL_INVESTIGATOR
National Heart, Lung, and Blood Institute (NHLBI)

Study Locations (Sites)

National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
United States

Collaborators and Investigators

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

  • Warren J Leonard, M.D., PRINCIPAL_INVESTIGATOR, National Heart, Lung, and Blood Institute (NHLBI)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2004-04-05
Study Completion DateN/A

Study Record Updates

Study Start Date2004-04-05
Study Completion DateN/A

Terms related to this study

Keywords Provided by Researchers

  • Cytokines
  • Inherited Immunodeficiency
  • Natural History

Additional Relevant MeSH Terms

  • Severe Combined Immunodeficiency