RECRUITING

Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The hypothesis for this study is that a preparative regimen that maximizes host immunosuppression without myeloablation will be well tolerated and sufficient for engraftment of donor hematopoietic cells. It is also to determine major toxicities from these conditioning regimens, within the first 100 days after transplantation.

Official Title

A Study of Hematopoietic Stem Cell Transplantation (HSCT) in Non-Malignant Disease Using a Reduced-Intensity Preparatory Regime

Quick Facts

Study Start:2001-12
Study Completion:2031-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT00920972

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified to 20 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Recipient age \< 21 years
  2. * Lansky/Karnofsky \>/= 40
  3. * Adequate pulmonary, renal, liver, and other organ function as defined in protocol
  4. * Negative pregnancy test
  5. * Adequate total nucleated cell or CD34+ dose of product as defined in protocol
  6. * If sickle cell, Hemoglobin S \<30%
  1. * HIV positive
  2. * Invasive infection
  3. * Pregnancy/lactating

Contacts and Locations

Study Contact

Stephanie Hyde, CCRP
CONTACT
3142861180
stephanie.day@wustl.edu

Principal Investigator

Shalini Shenoy, MD
PRINCIPAL_INVESTIGATOR
Washington University School of Medicine (in St. Louis)

Study Locations (Sites)

Phoenix Children's Hospital
Phoenix, Arizona, 85016
United States
Children's Hospital of Orange County
Orange, California, 92868
United States
University of California
San Diego, California, 92123
United States
Yale School of Medicine
New Haven, Connecticut, 06510
United States
George Washington University School of Medicine
Washington, District of Columbia, 20010
United States
University of Miami
Miami, Florida, 33136
United States
Miami Children's Hospital
Miami, Florida, 33155
United States
All Children's Hospital
Saint Petersburg, Florida, 33701
United States
Children's Memorial Hospital
Chicago, Illinois, 60614
United States
Indiana University School of Medicine
Indianapolis, Indiana, 46202
United States
St. Louis University
Saint Louis, Missouri, 63104
United States
Washington University School of Medicine (in St. Louis)
Saint Louis, Missouri, 63110
United States
Hackensack University Medical Center
Hackensack, New Jersey, 07601
United States
Columbia University Medical Center
New York, New York, 10032
United States
Carolinas Medical Center
Charlotte, North Carolina, 28232
United States
The University of Oklahoma
Oklahoma City, Oklahoma, 73104
United States
Texas Transplant Institute
San Antonio, Texas, 78229
United States

Collaborators and Investigators

Sponsor: Washington University School of Medicine

  • Shalini Shenoy, MD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine (in St. Louis)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2001-12
Study Completion Date2031-12

Study Record Updates

Study Start Date2001-12
Study Completion Date2031-12

Terms related to this study

Keywords Provided by Researchers

  • Bone marrow
  • Transplant
  • Transplantation
  • Hematopoietic
  • Umbilical cord
  • Related
  • Unrelated
  • Reduced
  • Non-myeloablative
  • Nonmyeloablative
  • Non-malignant
  • Nonmalignant

Additional Relevant MeSH Terms

  • Metabolic Disorders
  • Hematologic, Immune, or Bone Marrow Disorders
  • Hemoglobinopathies
  • Non-malignant Disorders