RECRUITING

Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological Studies

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Background: \- Laboratory investigators who are studying common childhood cancers are interested in developing a tissue repository to collect and store blood, serum, tissue, urine, or tumors of children who have cancer or adults who have common childhood cancers. To develop this repository, additional samples will be collected from children and adults who have been diagnosed with common childhood cancers such as leukemia and tumors of the central nervous system. Objectives: \- To collect and store blood, serum, tissue, urine, or tumor samples of children who have cancer or adults who have common childhood cancers. Eligibility: * Individuals who have been diagnosed with a common childhood cancer (e.g., leukemia) regardless of patient age. * Children, adolescents, and adults who have been diagnosed with a type of cancer more commonly found in adults. Design: * Extra blood, serum (the liquid part of blood), tissue, urine, or tumor samples will be collected from participants at a time when sampling is required for medical care or as part of a research study. * No additional procedures will be performed for the sole purpose of obtaining additional tumor tissue, aside from what is required for clinical care.

Official Title

Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological Studies

Quick Facts

Study Start:2010-04-21
Study Completion:N/A
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01109394

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:4 Weeks
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosis of any tumor, malignancy, pre-malignant disorder, or suspected premalignant familial syndromes, regardless, of patient age;
  2. * Biological relatives of any patient with a tumor, malignancy, pre-malignant disorder, or suspected familial pre-malignant syndrome, regardless of patient age or the diagnosis of an adult malignancy or pre-malignant disorder;
  3. * Healthy Volunteer without history of malignancy nor a family member currently being treated for cancer who are undergoing surgery, treatment or during well visits;
  4. * Biospecimens can be collected with minimal additional risk to the subject during sampling or procedures required for routine patient care.
  5. * Human samples, specimens and data collected on IRB approved protocols that are now closed
  6. * Ability of subject, Legally Authorized Representative (LAR), or parent/legal guardian of children less than or equal to 18 to understand and be willing to sign an IRB-approved informed consent document that permits the use of the tumor and other samples for genomic-based molecular characterization projects.
  7. * Parent/caregiver of a participating pediatric or adult patient who is being treated for, or who has previously been treated for any form of pediatric cancer.
  8. * Must be able to give consent and sign the informed consent document.
  9. * Able to understand the English language.
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Donna B Bernstein, R.N.
CONTACT
(240) 760-6189
bernsted@mail.nih.gov
Rosandra N Kaplan, M.D.
CONTACT
(240) 760-6198
kaplanrn@mail.nih.gov

Principal Investigator

Rosandra N Kaplan, M.D.
PRINCIPAL_INVESTIGATOR
National Cancer Institute (NCI)

Study Locations (Sites)

Children's National Medical Center
Washington D.C., District of Columbia, 20010
United States
Children's Hospital of Orange County (CHOC Children's)
Orange, Florida, 92613
United States
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
United States
Tisch Cancer Institute, Mount Sinai Medical Center
New York, New York, 10029-0574
United States
Carolinas Medical Center/Levine Children's Hospital
Charlotte, North Carolina, 28203
United States

Collaborators and Investigators

Sponsor: National Cancer Institute (NCI)

  • Rosandra N Kaplan, M.D., PRINCIPAL_INVESTIGATOR, National Cancer Institute (NCI)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2010-04-21
Study Completion DateN/A

Study Record Updates

Study Start Date2010-04-21
Study Completion DateN/A

Terms related to this study

Keywords Provided by Researchers

  • Genomics
  • Proteomics
  • Tissue Repository
  • Omics
  • Cell Lines
  • Natural History
  • Pediatric Cancer
  • Solid Tumor
  • Sarcoma
  • Kidney Cancer
  • Neuroblastoma

Additional Relevant MeSH Terms

  • Sarcoma
  • Endocrine Tumors
  • Neuroblastoma
  • Retinoblastoma
  • Renal Cancer