RECRUITING

Mediators of Atherosclerosis in South Asians Living in America

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) individuals have high rates of cardiovascular disease that is not explained by traditional cardiovascular risk factors. Though South Asians represent over one-quarter of the world's population, there are no longitudinal studies in this high-risk ethnic group. The investigators aim to establish a longitudinal study of South Asians at three United States centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. The purpose of this study is to understand the causes of heart disease and stroke in South Asians and compare these causes to those in other United States ethnic groups.

Official Title

Mediators of Atherosclerosis in South Asians Living in America

Quick Facts

Study Start:2010-09
Study Completion:2025-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01207167

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years to 84 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * South Asian ancestry defined by having at least 3 grandparents born in one of the following countries: India, Pakistan, Bangladesh, Nepal, or Sri Lanka
  2. * age between 40 and 84 years.
  1. * Physician diagnosed heart attack, stroke or transient ischemic attack (TIA), heart failure, or angina (or use of nitroglycerin)
  2. * Current atrial fibrillation
  3. * Past history of cardiovascular procedures (coronary artery bypass graft (CABG) Surgery, angioplasty, valve replacement, pacemaker or defibrillator implantation, or any surgery on the heart or arteries)
  4. * Active treatment for cancer
  5. * Life expectancy less than 5 years due to serious medical illness
  6. * Impaired cognitive ability as judged by the reviewer
  7. * Plans to move out of the study region in next 5 years
  8. * Weight greater than 300 pounds
  9. * Living in a nursing home or on a waiting list
  10. * Unable to speak/read/write English, Hindi, Urdu, or Bangla

Contacts and Locations

Study Contact

Alka Kanaya, MD
CONTACT
alka.kanaya@ucsf.edu
Ann Chang
CONTACT
ann.chang@ucsf.edu

Principal Investigator

Alka Kanaya, MD
PRINCIPAL_INVESTIGATOR
University of California, San Francisco
Namratha Kandula, MD
PRINCIPAL_INVESTIGATOR
Northwestern University
Nadia Islam, PhD
PRINCIPAL_INVESTIGATOR
New York University

Study Locations (Sites)

University of California, San Francisco
San Francisco, California, 94115
United States
Northwestern University
Chicago, Illinois, 60611
United States
New York University
New York, New York
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • Alka Kanaya, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco
  • Namratha Kandula, MD, PRINCIPAL_INVESTIGATOR, Northwestern University
  • Nadia Islam, PhD, PRINCIPAL_INVESTIGATOR, New York University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2010-09
Study Completion Date2025-12

Study Record Updates

Study Start Date2010-09
Study Completion Date2025-12

Terms related to this study

Additional Relevant MeSH Terms

  • Atherosclerosis
  • Cardiovascular Diseases
  • Heart Diseases
  • Coronary Artery Disease
  • Coronary Disease