RECRUITING

Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Background: \- Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of the human body and evaluate activity in the brain. A particular MRI method called magnetic resonance spectroscopy (MRS) can be used to study brain chemistry as well, which may help researchers who are studying new treatments for psychiatric illnesses. Researchers are interested in improving current MRI and MRS techniques, as well as developing new MRI and MRS techniques to view and measure brain chemicals and brain activity. Objectives: \- To implement, develop, and optimize brain chemistry imaging techniques using magnetic resonance imaging and magnetic resonance spectroscopy. Eligibility: \- Healthy individuals between 18 and 65 years of age. Design: * This study will involve a screening visit and a scanning visit at the National Institutes of Health Clinical Center. * Participants will be screened with a full medical and physical examination, blood and urine tests, and neurological testing. * During the second visit, participants will have an MRI scan of the brain. (Participants who have received an MRI within the past year will not need to have a second one; the images of the previous scan will be used for this study.) All participants will then have an MRS scan using the same scanning equipment.

Official Title

Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

Quick Facts

Study Start:2011-01-27
Study Completion:2026-10-23
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01266577

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18-65 years of age
  2. * able to give written informed consent
  3. * healthy based on medical history and physical exam
  4. * enrolled in Protocol 01-M-0254 or Protocol 17-M-0181
  1. * Any current Axis 1 diagnosis
  2. * Clinically significant laboratory abnormalities
  3. * Positive HIV test
  4. * Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
  5. * History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury
  6. * Inability to lie flat on camera bed for about two and a half hours
  7. * Pregnant or breastfeeding
  8. * Current substance use disorder based on DSM-5
  9. * NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.

Contacts and Locations

Study Contact

Christopher S Johnson
CONTACT
(301) 402-6695
johnsonchri@mail.nih.gov
Li An, Ph.D.
CONTACT
(301) 896-2882
anl@mail.nih.gov

Principal Investigator

Li An, Ph.D.
PRINCIPAL_INVESTIGATOR
National Institute of Mental Health (NIMH)

Study Locations (Sites)

National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
United States

Collaborators and Investigators

Sponsor: National Institute of Mental Health (NIMH)

  • Li An, Ph.D., PRINCIPAL_INVESTIGATOR, National Institute of Mental Health (NIMH)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2011-01-27
Study Completion Date2026-10-23

Study Record Updates

Study Start Date2011-01-27
Study Completion Date2026-10-23

Terms related to this study

Keywords Provided by Researchers

  • Brain Metabolism
  • Neurochemistry
  • Magnetic Resonance Imaging
  • Mental Illness
  • Magnetic Resonance Spectroscopy

Additional Relevant MeSH Terms

  • Brain Mapping
  • Healthy Volunteer