RECRUITING

Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

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Conditions

Chronic Obstructive Pulmonary Disease (COPD)SmokingSmoking CessationIdiopathic Pulmonary Fibrosis (IPF)Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD)Scleroderma-Associated Interstitial Lung Disease (SSC-ILD)COPDChronic Obstructive Pulmonary DiseaseLung diseaseEmphysemaHealthy SmokerSmokerNon-smokerIPFRA-ILDSSC-ILDIdiopathic Pulmonary FibrosisRheumatoid Arthritis-Associated Interstitial Lung DiseaseScleroderma-Associated Interstitial Lung Disease

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to obtain biologic materials from the blood, airways and/or urine of normal individuals and individuals with lung disease. The normal are used to establish a set of normal ranges for various parameters. These provide control information when compared to individuals with various pulmonary diseases, and will help in understanding of the etiology and pathogenesis of various lung diseases. The underlying hypothesis is that the pathologic morphological changes in the airway epithelium must be preceded by changes in the gene expression pattern of the airway epithelium and potentially in macrophages.

Official Title

Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

Quick Facts

Study Start:2012-08-29
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01776398

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * All study subjects should be able to provide informed consent
  2. * Males or females ages 18 years and older
  3. * Must provide HIV informed consent
  4. * Must provide informed consent
  5. * Males and females age 18 years and older
  6. * Lung disease proven by at least one of the following: symptoms consistent with pulmonary disease; (2) chest X-rays consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; and/or (6) diseases of organs with known association with lung disease
  7. * Must provide HIV informed consent
  8. * Must provide informed consent
  9. * Males and females, age 18 years and older
  10. * Lung disease proven by at least one of the following: (1) symptoms consistent with pulmonary disease; (2) chest X-rays consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; (6) diseases of organs with known association with lung disease, and (7) individuals with the blood eosinophil levels of 5% or greater.
  11. * Must provide informed consent
  12. * Males and females, age 18 years and older
  13. * Lung disease proven by at least one of the following: symptoms consistent with pulmonary disease; (2) chest X-rays consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; and (6) diseases of organs with known association with lung disease
  1. * Individuals not deemed in good overall health by the investigator during screening visits and/or prior to the bronchoscopy will not be accepted into the study.
  2. * Individuals with history of chronic lung disease, including asthma or with recurrent or recent (within three months) acute pulmonary disease will not be accepted into the study.
  3. * Individuals with allergies to atropine or any local anesthetic will not be accepted into the study.
  4. * Individuals with allergies to pilocarpine, isoproterenol, terbutaline, atropine or aminophylline will not be accepted into the study.
  5. * Females who are pregnant or nursing will not be accepted into the study
  6. * Any history of allergies to xylocaine, lidocaine, versed, valium, atropine, pilocarpine, isoproterenol, terbutaline, aminophylline, or any local anesthetic will not be included in the study
  7. * Individuals deemed unable to complete the bronchoscopy due to health concerns by the investigator.
  8. * Females who are pregnant or nursing
  9. * Experienced a recent (≤ 8 weeks) pulmonary exacerbation of their disease
  10. * Patient refuses consent
  11. * Patient refuses consent

Contacts and Locations

Study Contact

Niamh Savage
CONTACT
12127460284
nis2049@med.cornell.edu

Principal Investigator

Ronald G. Crystal, M.D.
PRINCIPAL_INVESTIGATOR
Weill Medical College of Cornell University

Study Locations (Sites)

Weill Cornell Medical College and Weill Cornell Medical Center, Department of Genetic Medicine
New York, New York, 10065-4870
United States

Collaborators and Investigators

Sponsor: Weill Medical College of Cornell University

  • Ronald G. Crystal, M.D., PRINCIPAL_INVESTIGATOR, Weill Medical College of Cornell University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2012-08-29
Study Completion Date2026-12

Study Record Updates

Study Start Date2012-08-29
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • COPD
  • Chronic Obstructive Pulmonary Disease
  • Lung disease
  • Emphysema
  • Smoking
  • Healthy Smoker
  • Smoker
  • Non-smoker
  • IPF
  • RA-ILD
  • SSC-ILD
  • Idiopathic Pulmonary Fibrosis
  • Rheumatoid Arthritis-Associated Interstitial Lung Disease
  • Scleroderma-Associated Interstitial Lung Disease

Additional Relevant MeSH Terms

  • Chronic Obstructive Pulmonary Disease (COPD)
  • Smoking
  • Smoking Cessation
  • Idiopathic Pulmonary Fibrosis (IPF)
  • Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD)
  • Scleroderma-Associated Interstitial Lung Disease (SSC-ILD)