RECRUITING

International Rare Histiocytic Disorders Registry (IRHDR)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The rare histiocytic disorders (RHDs) are characterized by the infiltration of one or more organs by non-LCH histiocytes. They can range from localized disease that resolves spontaneously, to progressive disseminated forms that can be sometimes life-threatening. Since they are extremely rare, there is limited understanding of their causes and best treatment options. Physicians, patients and parents of children with RHDs frequently consult members of the Histiocyte Society regarding the best management of these disorders. Very often, no specific recommendation can be made due to the lack of prospective outcome data, or even large retrospective case series. The creation of an international rare histiocytic disorders registry (IRHDR) could facilitate a uniform diagnosis of the RHDs, as well as the collection and analysis of the clinical, epidemiological, treatment and survival data of patients with RHD. The registry may also lead to future therapeutic recommendations, provide a framework for future clinical trials and create excellent research opportunities.

Official Title

International Rare Histiocytic Disorders Registry (IRHDR)

Quick Facts

Study Start:2014-10
Study Completion:2028-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02285582

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Any age at diagnosis.
  2. * Diagnosis of a rare histiocytic disorder, established before or after the opening of the registry.
  3. * Cases diagnosed from January - 01- 1995 until the present time and prospectively.
  4. * Suitable pathology sample available for central review.
  5. * Signed informed consent by a patient, or parent/legal guardian.
  6. * Cognitively impaired patients can be included after consent by legal guardian/parent.
  7. * Deceased patients can be included provided that they are contacted at least 6 months after the death of their child and not on their child's birthday or anniversary of death.
  1. * Informed consent has not been signed.
  2. * Diagnosis other than RHD.
  3. * Patients with no pathology sample available for central review.
  4. * Cases diagnosed before the year 1995

Contacts and Locations

Study Contact

Oussama Abla, MD
CONTACT
416-813-7879
oussama.abla@sickkids.ca

Principal Investigator

Oussama Abla, MD
PRINCIPAL_INVESTIGATOR
The Hospital for Sick Children

Study Locations (Sites)

Children's Hospital of Los Angeles
Los Angeles, California, 90027
United States
Valley Children's Hospital
Madera, California, 93636
United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
United States
Memorial Sloan Kettering Cancer Center
New York, New York, 10022
United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15219
United States

Collaborators and Investigators

Sponsor: The Hospital for Sick Children

  • Oussama Abla, MD, PRINCIPAL_INVESTIGATOR, The Hospital for Sick Children

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2014-10
Study Completion Date2028-09

Study Record Updates

Study Start Date2014-10
Study Completion Date2028-09

Terms related to this study

Additional Relevant MeSH Terms

  • Rare Histiocytic Disorders (RHDs)
  • Juvenile Xanthogranuloma (JXG)
  • Reticulohistiocytoma (epithelioid Histiocytoma)
  • Xanthoma Disseminatum (XD)
  • Multicentric Reticulohistiocytosis (MRH)
  • Systemic Juvenile Xanthogranuloma
  • Erdheim-Chester Disease (ECD)
  • Multi-system Rosai-Dorfman Disease (RDD)