RECRUITING

Lovenox 30 mg Twice Daily (BID) Versus 40 mg Once Daily (QD)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The risk of developing a blood clot occurs in up to 60% of all critical care patients. Many times enoxaparin (or Lovenox) is given to patients who are at a higher risk of developing clots in their legs or lungs. There are two standard doses of enoxaparin that are recommended by the drug companies. These two doses have never been directly compared in trauma, general, and vascular surgery patients. The purposes of this study are: 1. to compare the development of blood clots in patients receiving 30mg twice daily of enoxaparin compared to patients receiving 40mg once daily of enoxaparin. 2. to determine if there is higher risk of bleeding complications in patients receiving 30mg twice daily of enoxaparin compared to patients receiving 40mg once daily. Patients enrolled into the study will be randomized to receive enoxaparin, 30mg twice daily or enoxaparin, 40mg once daily. Patients will then be monitored for signs and symptoms of blood clots. At the time of discharge (or before, if medically indicated), an ultrasound test will be performed to look for blood clots in the patient's legs. The investigators will compare incidence of blood clots formed between the 2 groups of patients to determine if one dose of enoxaparin relates to a lower rate of blood clots in critically ill patients. The investigators will also compare the incidence of bleeding complications between the 2 groups.

Official Title

A Prospective Randomized Trial Comparing Two Standard Doses of Enoxaparin for the Prevention of Thromboembolism in Surgical Patients

Quick Facts

Study Start:2014-02
Study Completion:2025-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02342444

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:15 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Admitted patients requiring prophylactic dosing of enoxaparin (Lovenox)
  2. * Admitted to the trauma or surgical service
  3. * Age greater than 15 years
  1. * Unable to obtain consent from patient or authorized representative
  2. * Presence of intracranial hemorrhage
  3. * Receiving therapeutic dose of enoxaparin (Lovenox)
  4. * Receiving other forms of anticoagulation
  5. * Presence of renal failure requiring non-standard dosing regimen

Contacts and Locations

Study Contact

Laura Nguyen
CONTACT
nguyelau@ohsu.edu

Principal Investigator

Martin A Schreiber, MD
PRINCIPAL_INVESTIGATOR
Oregon Health and Science University

Study Locations (Sites)

Oregon Health & Science University
Portland, Oregon, 97239
United States

Collaborators and Investigators

Sponsor: Oregon Health and Science University

  • Martin A Schreiber, MD, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2014-02
Study Completion Date2025-03-31

Study Record Updates

Study Start Date2014-02
Study Completion Date2025-03-31

Terms related to this study

Keywords Provided by Researchers

  • Trauma
  • Surgery
  • Enoxaparin
  • DVTs
  • Thromboembolic events

Additional Relevant MeSH Terms

  • Trauma
  • Surgery
  • Deep Vein Thrombosis (DVT)
  • Thromboembolic Events