RECRUITING

Exercise and Brain Health

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The risk of stroke and vascular dementia is high in individuals who have had a prior stroke or TIA, and in those who have vascular disease risk factors, such as high blood pressure, abnormal cholesterol, diabetes or pre-diabetes. These vascular risk factors can improve with exercise. This study will examine the impact of a 6 month, low intensity group exercise class on fitness, walking, balance, and brain health. This study will also collect fitness, walking, balance, and brain health outcome measures at baseline and post all other MERCE exercise and robotics interventions.

Official Title

Exercise and Brain Health

Quick Facts

Study Start:2013-07
Study Completion:2025-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02626442

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 95 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adequate language and neurocognitive function to participate in testing and training and to give adequate informed consent
  2. * Able to rise from a chair unaided
  3. * Completion of all regular post-stroke physical therapy (if applicable)
  4. * Able to walk 30 feet without human assistance
  1. * Clinical history of
  2. * unstable angina
  3. * recent (\< 3 months) myocardial infarction or congestive heart failure (NYHA category II)
  4. * hemodynamically significant valvular dysfunction
  5. * peripheral arterial obstructive disorder with claudication
  6. * major orthopedic, chronic pain, or non-stroke neuromuscular disorders restricting exercise
  7. * pulmonary or renal failure
  8. * poorly controlled hypertension (\>190/110), measured on at least two separate occasions
  9. * recent hospitalization for severe disease or surgery
  10. * severe or global receptive aphasia which confounds reliable testing and training
  11. * Other medical condition precluding patient participation in this study as per medical judgment of study team
  12. * Untreated major depression
  13. * Pregnancy
  14. * Alcohol consumption \> 3 oz. liquor, or 3 x 4 oz glasses of wine, or 3 x 12 oz. beers per day, by self-report
  15. * Dementia and other major cognitive deficits (based upon clinical evaluation)

Contacts and Locations

Study Contact

Rich Macko, MD
CONTACT
410-605-7000
rmacko@grecc.umaryland.edu
Charlene Hafer-Macko, MD
CONTACT
410-605-7000
cmacko@grecc.umaryland.edu

Principal Investigator

Emily Byrne, BS
STUDY_DIRECTOR
Baltimore VA Medical Center

Study Locations (Sites)

Baltimore VA Medical Center
Baltimore, Maryland, 21201
United States

Collaborators and Investigators

Sponsor: Baltimore VA Medical Center

  • Emily Byrne, BS, STUDY_DIRECTOR, Baltimore VA Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2013-07
Study Completion Date2025-01

Study Record Updates

Study Start Date2013-07
Study Completion Date2025-01

Terms related to this study

Keywords Provided by Researchers

  • Cognition
  • Exercise

Additional Relevant MeSH Terms

  • Stroke
  • Cardiovascular Risk Factors
  • Transient Ischemic Attack (TIA)