RECRUITING

Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

Description

The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).

Study Overview

Study Details

Study overview

The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).

Randomized Trial of the NeoChord™ DS1000™ System Versus Open Surgical Repair

Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

Condition
Mitral Valve Insufficiency
Intervention / Treatment

-

Contacts and Locations

Oakland

Sutter Health/Alta Bates Summitt Medical Center, Oakland, California, United States, 94609

Sacramento

Mercy General Hospital, Sacramento, California, United States, 95819

Stanford

Stanford University, Stanford, California, United States, 94305

Washington

MedStar Washington Hospital Center, Washington, District of Columbia, United States, 20010

Orlando

Florida Hospital, Orlando, Florida, United States, 32803

Atlanta

Piedmont Heart Institute, Atlanta, Georgia, United States, 30339

Indianapolis

Franciscan Health, Indianapolis, Indiana, United States, 46237

Baltimore

Johns Hopkins University, Baltimore, Maryland, United States, 21287

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48109

New York

Mount Sinai, Icahn School of Medicine, New York, New York, United States, 10029

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Is a candidate for mitral valve repair with cardiopulmonary bypass
  • * Has Grade III moderate or Grade IV severe degenerative mitral valve regurgitation
  • * Primary segmental prolapse of the A2 or P2 segment or prolapse extending to an adjacent segment (P1, P3, A1, A3) who have a single eccentric regurgitant jet on echocardiogram
  • * Anterior leaflet covers at least 65% of anterior-posterior annular distance or an anterior leaflet that would provide sufficient coaptation after chord placement
  • * Anatomic and general suitability
  • * Prior mitral valve surgery
  • * Concomitant cardiac procedures
  • * Other cardiac procedures within 3 months

Ages Eligible for Study

21 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

NeoChord,

Study Record Dates

2027-07