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Pre-myeloid Cancer and Bone Marrow Failure Clinic Study

Description

This clinical trial tests next generation sequencing (NGS) for the detection of precursor features of pre-myeloid cancers and bone marrow failure syndromes. NGS is a procedure that looks at relevant cancer associated genes and what they do. Finding genetic markers for pre-malignant conditions may help identify patients who are at risk of pre-myeloid cancers and bone marrow failure syndromes and lead to earlier intervention.

Conditions

Myeloid MalignancyInherited Bone Marrow Failure SyndromeClonal ExpansionCytopeniaBone Marrow Failure SyndromeClonal Cytopenia of Undetermined SignificanceClonal Hematopoiesis of Indeterminate PotentialHematologic NeoplasmsHematopoietic and Lymphatic System NeoplasmHereditary Neoplastic SyndromeIdiopathic Cytopenia of Undetermined SignificanceIdiopathic Dysplasia of Uncertain SignificanceLow Risk Myelodysplastic Syndrome
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Related Conditions:

Myeloid MalignancyInherited Bone Marrow Failure SyndromeClonal ExpansionCytopeniaBone Marrow Failure SyndromeClonal Cytopenia of Undetermined SignificanceClonal Hematopoiesis of Indeterminate PotentialHematologic NeoplasmsHematopoietic and Lymphatic System NeoplasmHereditary Neoplastic SyndromeIdiopathic Cytopenia of Undetermined SignificanceIdiopathic Dysplasia of Uncertain SignificanceLow Risk Myelodysplastic Syndrome

Study Overview

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Study Details

Study overview

This clinical trial tests next generation sequencing (NGS) for the detection of precursor features of pre-myeloid cancers and bone marrow failure syndromes. NGS is a procedure that looks at relevant cancer associated genes and what they do. Finding genetic markers for pre-malignant conditions may help identify patients who are at risk of pre-myeloid cancers and bone marrow failure syndromes and lead to earlier intervention.

Pre-myeloid Cancer and Bone Marrow Failure Clinic Study

Pre-myeloid Cancer and Bone Marrow Failure Clinic Study

Condition
Myeloid Malignancy
Intervention / Treatment

-

Contacts and Locations

Scottsdale

Mayo Clinic in Arizona, Scottsdale, Arizona, United States, 85259

Jacksonville

Mayo Clinic in Florida, Jacksonville, Florida, United States, 32224-9980

Rochester

Mayo Clinic in Rochester, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients with idiopathic cytopenias of unclear significance (ICUS)
  • * Patients with clonal hematopoiesis of indeterminate significance (clonal hematopoiesis of indeterminate potential \[CHIP\]), including the recently described CHIP syndrome called VEXAS (vacuoles, E1 ubiquitin ligase, X chromosomal, autoimmune and somatic)
  • * Patients with clonal cytopenias of undetermined significance (CCUS)
  • * Marrow failure syndromes with myeloid malignancy predisposition - telomere dysfunction, chromosomal breakage disorders
  • * Germ line inherited syndromes with risk for malignant transformation - GATA2, CEBPA, ETV-6, RUNX1, JAK2, PF6, etc.
  • * Low risk MDS (idiopathic dysplasia of unclear significance)
  • * Family member of a patient with one of the above conditions
  • * Patient at high risk or suspected of developing one of the above conditions
  • * Patients under 18 years of age

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Mrinal S. Patnaik, MBBS, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2035-09-15