RECRUITING

Whole-Heart Myocardial Blood Flow Quantification Using MRI

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study hopes to provide significant technical improvement in a Myocardial Blood Flow (MBF) cardiac magnetic resonance (CMR) quantification technique to address challenges and technical limitations for MBF CMR. By developing and validating novel techniques to improve first-pass perfusion (FPP) cardiac MR, we propose to increase diagnostic accuracy by minimizing false positives and false negatives, allow for better evaluation and accurate quantification of total ischemic burden and reduce image and motion-induced artifacts. The broad, long-term objective of the proposed project is to improve the prognosis of patients with myocardial ischemia caused by coronary artery disease (CAD) or coronary microvascular dysfunction (CMD).

Official Title

Whole-Heart Myocardial Blood Flow Quantification Using Magnetic Resonance Imaging

Quick Facts

Study Start:2018-03-01
Study Completion:2025-01-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03064295

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 60 healthy male or female (18 or older) participants
  2. * 110 male or female adults (18 or older) who have undergone clinical myocardial perfusion imaging at CSMC and been diagnosed with Coronary Disease (CAD).
  3. * 50 female adults (21 or older) who have undergone coronary reactivity testing at CSMC and been diagnosed with coronary microvascular disease (CMD).
  1. * MR imaging is contraindicated in persons with mechanically, magnetically, or electrically activated implants, such as cardiac pacemakers, neurostimulators, and infusion pumps.
  2. * Persons with ferromagnetic implants and ferromagnetic foreign bodies, such as intracranial, aneurysm clips, shrapnel and intraocular metal chips as these could become dislodged.
  3. * Patients who are pregnant, nursing, implanted with non MR-compatible intrauterine devices (IUD's)
  4. * Persons unable to tolerate MRI imaging secondary to an inability to lie supine or severe claustrophobia.
  5. * Persons who are non-compliant with visit instructions, including inability to lie still, hold breath or follow procedure instructions
  6. * Persons whose renal function test does not meet CSMC standard of care MRI contrast protocol requirements (GFR \<45ml/min).
  7. * Persons with stated allergy to animal dander
  8. * acute coronary syndrome or acute myocardial infarction or ongoing myocardial ischemia or ECG evidence of ongoing ischemia;
  9. * patients with concurrent cardiogenic shock or requiring inotropic or intra-aortic balloon support or prior/planned PCI or CABG;
  10. * non-ischemic cardiomyopathy or more than moderate valvular disease;
  11. * contraindication to stress agent (adenosine) including asthma or prior adverse reaction to adenosine
  12. * contraindications for gadolinium contrast;

Contacts and Locations

Study Contact

Johanna Kim, MPH
CONTACT
310 248-8668
johanna.kim@cshs.org

Principal Investigator

Zhaoyang Fan, PhD
PRINCIPAL_INVESTIGATOR
Cedars-Sinai Medical Center

Study Locations (Sites)

Cedars-Sinai Medical Center
Los Angeles, California, 90048
United States

Collaborators and Investigators

Sponsor: Cedars-Sinai Medical Center

  • Zhaoyang Fan, PhD, PRINCIPAL_INVESTIGATOR, Cedars-Sinai Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-03-01
Study Completion Date2025-01-01

Study Record Updates

Study Start Date2018-03-01
Study Completion Date2025-01-01

Terms related to this study

Additional Relevant MeSH Terms

  • Coronary Artery Disease
  • Coronary Microvascular Disease