RECRUITING

Retinal Imaging in Neurodegenerative Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.

Official Title

Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study

Quick Facts

Study Start:2017-07-20
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03233646

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome)
  2. * Adults without neurodegenerative disease
  1. * Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition.
  2. * Eyes that have had intraocular surgery, other than cataract surgery.

Contacts and Locations

Study Contact

Sharon Fekrat, MD FACS FASRS
CONTACT
919-681-3937
imind@duke.edu

Principal Investigator

Sharon Fekrat, MD FACS FASRS
PRINCIPAL_INVESTIGATOR
Duke University
Dilraj Grewal, MD
PRINCIPAL_INVESTIGATOR
Duke University

Study Locations (Sites)

Duke University Medical Center
Durham, North Carolina, 27705
United States

Collaborators and Investigators

Sponsor: Duke University

  • Sharon Fekrat, MD FACS FASRS, PRINCIPAL_INVESTIGATOR, Duke University
  • Dilraj Grewal, MD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2017-07-20
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2017-07-20
Study Completion Date2025-12-31

Terms related to this study

Keywords Provided by Researchers

  • OCT angiography (OCTA)
  • Optical Coherence Tomography (OCT)
  • Vessel Density
  • Superficial Capillary Plexus
  • Retinal microvasculature
  • Scanning Laser Ophthalmoscopy
  • Ultra-widefield (UWF) Imaging
  • Perfusion Density
  • Retinal Nerve Fiber Layer
  • Ganglion Cell Inner Plexiform Layer
  • Choroidal Vascularity Index

Additional Relevant MeSH Terms

  • Alzheimer's Disease
  • Mild Cognitive Impairment
  • Parkinson's Disease
  • Multiple Sclerosis
  • Huntington Disease
  • Lewy Body Dementia
  • Frontotemporal Dementia
  • Amyotrophic Lateral Sclerosis (ALS)
  • APOE-4 Positive
  • Traumatic Brain Injury
  • Concussion
  • Post-Traumatic Stress Disorder
  • Down Syndrome
  • Neuro-Degenerative Disease
  • Normal Cognition