RECRUITING

Mechanistic Clinical Trial of Advanced Imaging for CRT

Description

This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.

Conditions

Heart Failure, Systolic
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Related Conditions:

Heart Failure, Systolic

Study Overview

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Study Details

Study overview

This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.

Advanced Imaging and Inflammatory Markers to Define Mechanisms of Response to CRT

Mechanistic Clinical Trial of Advanced Imaging for CRT

Condition
Heart Failure, Systolic
Intervention / Treatment

-

Contacts and Locations

Charlottesville

University of Virginia Health System, Charlottesville, Virginia, United States, 22908

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Chronic systolic HF
  • 2. LVEF 35% or less
  • 3. Guideline-based class I or II indication for CRT
  • 1. Inability to provide informed consent
  • 2. Pregnancy
  • 3. Presence of metal embedded in the body due to prior accident or injury, as documented by skull films or other imaging
  • 4. Cerebral aneurysm clips
  • 5. Cochlear implants
  • 6. Other metallic implants known to be contraindications to CMR (does not include pacemakers and ICDs)
  • 7. Severe claustrophobia
  • 8. Acute kidney injury
  • 9. Acute renal failure or chronic kidney disease with GFR \< 45 cc/min/1.73m2
  • 10. Liver transplant
  • 11. Gadolinium allergy
  • 12. \>10% premature ventricular contraction (PVC) burden; and 13) estimated \>10% atrial fibrillation (AF) burden based on available clinical data.

Ages Eligible for Study

20 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Virginia,

Kenneth C Bilchick, MD, PRINCIPAL_INVESTIGATOR, University of Virginia Health System

Study Record Dates

2025-01-15