SHIPSS is a multi-institutional, prospective, controlled, randomized, double-blinded interventional trial that will examine the potential benefits and risks of adjunctive hydrocortisone prescribed for children with fluid and vasoactive-inotropic refractory septic shock. It is hypothesized that adjunctive hydrocortisone will significantly reduce the incidence of new and progressive organ dysfunction (primary outcome) and proportion of children with poor outcomes, defined as death or severely impaired health-related quality of life (HRQL) (secondary outcome), as assessed at 28 days following study enrollment (randomization).
SHIPSS is a multi-institutional, prospective, controlled, randomized, double-blinded interventional trial that will examine the potential benefits and risks of adjunctive hydrocortisone prescribed for children with fluid and vasoactive-inotropic refractory septic shock. It is hypothesized that adjunctive hydrocortisone will significantly reduce the incidence of new and progressive organ dysfunction (primary outcome) and proportion of children with poor outcomes, defined as death or severely impaired health-related quality of life (HRQL) (secondary outcome), as assessed at 28 days following study enrollment (randomization).
Stress Hydrocortisone In Pediatric Septic Shock
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University of Arizona Medical Centre, Tucson, Arizona, United States, 85724
Children's Hospital of Los Angeles, Los Angeles, California, United States, 90027
UCSF Benioff Children's Hospital - Oakland, Oakland, California, United States, 94609
Children's Hospital of Orange County, Orange, California, United States, 92868
UCSF Benioff Children's Hospital - San Francisco, San Francisco, California, United States, 94143
Nemours Children's Health, Wilmington, Delaware, United States, 19803
University of Chicago, Comer Children's Hospital, Chicago, Illinois, United States, 60637
The University of Illinois at Chicago/OSF Children's Hospital of Illinois, Peoria, Illinois, United States, 61603
University of Louisville, Norton Children's Hospital, Louisville, Kentucky, United States, 40202
Boston Children's Hospital, Boston, Massachusetts, United States, 02115
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
1 Month to 17 Years
ALL
No
Jerry Zimmerman,
Jerry J Zimmerman MD, MD, PhD, PRINCIPAL_INVESTIGATOR, Seattle Children's Hospital, University of Washington School of Medicine
Michael Agus, MD, PRINCIPAL_INVESTIGATOR, Boston Children's Hospital, Harvard Medical School
Hector R Wong, MD, PRINCIPAL_INVESTIGATOR, Children's Hospital Medical Center, Cincinnati
David Wypij, PhD, PRINCIPAL_INVESTIGATOR, Boston Children's Hospital, Harvard Medical School
Kusum Menon, MD, MSc, PRINCIPAL_INVESTIGATOR, Children's Hospital of Eastern Ontario
2026-12-31