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Accelerated iTBS for Post Partum Depression

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Conditions

Post Partum Depressiontheta bursttranscranial magnetic stimulation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Study 1: The investigators are studying the feasibility and tolerability of 10x/day intermittent theta burst (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over the course of 6 days for women with post-partum depression. The investigators further aim to characterize the anticipated anti-depressant effect of this treatment paradigm. Study 2: The investigators are studying the feasibility and tolerability of 12 sessions/day of intermittent theta burse (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over 5 days for women with post-partum depression. The investigators aim to compare the two different treatment schedules.

Official Title

An Open Label Study to Assess the Feasibility and Tolerability of Accelerated Theta Burst Repetitive Transcranial Magnetic Stimulation (iTBS-rTMS) for the Treatment of Post-Partum Depression

Quick Facts

Study Start:2018-01-24
Study Completion:2024-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03417960

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Participants must be able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments.
  2. 2. Participants must be over the age of 18.
  3. 3. Participants must meet criteria for post-partum depression: a) onset of symptoms in the first year postpartum
  4. 4. Participants must have a HRSD17 greater than or equal to 14 at baseline.
  1. 1. Participants must not be pregnant.
  2. 2. Participants must not meet moderate or severe use disorder of any substance with the exception of Tobacco Use Disorder.
  3. 3. Participants must not have current psychotic symptoms.
  4. 4. Participants must not have a history of dementia or other cognitive impairment.
  5. 5. Participants must not have active suicidal ideation requiring hospitalization or a suicide attempt within the past 3 months.
  6. 6. Participants must not have any contraindications to receiving rTMS (e.g. metal implanted above the neck, history of seizure, any known brain lesion).
  7. 7. Participants must not have any unstable general medical conditions.
  8. 8. Participants must not have had eclampsia during pregnancy.

Contacts and Locations

Study Contact

Lisa McTeague, PhD
CONTACT
843-792-8274
mcteague@musc.edu

Study Locations (Sites)

Medical University of South Carolina
Charleston, South Carolina, 29425
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-01-24
Study Completion Date2024-12

Study Record Updates

Study Start Date2018-01-24
Study Completion Date2024-12

Terms related to this study

Keywords Provided by Researchers

  • post partum depression
  • theta burst
  • transcranial magnetic stimulation

Additional Relevant MeSH Terms

  • Post Partum Depression