RECRUITING

Pathogenetic Basis of Aortopathy and Aortic Valve Disease

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Conditions

AortopathiesThoracic Aortic AneurysmAortic Valve DiseaseThoracic Aortic DiseaseThoracic Aortic DissectionThoracic Aortic RuptureAscending Aortic DiseaseDescending Aortic DiseaseAscending Aortic AneurysmDescending Aortic AneurysmMarfan SyndromeLoeys-Dietz SyndromeVascular Ehlers-Danlos SyndromeShprintzen-Goldberg SyndromeTurner SyndromePHACE SyndromeAutosomal Recessive Cutis LaxaCongenital Contractural ArachnodactylyArterial Tortuosity SyndromeBicuspid Aortic Valve-Associated AortopathyBicuspid Aortic ValveFamilial Thoracic Aortic Aneurysm and Aortic DissectionCardiac DiseaseCardiovascular Genetics

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by identifying important genetic modifiers for aortic and aortic valve disease severity.

Official Title

Pathogenetic Basis of Aortopathy and Aortic Valve Disease

Quick Facts

Study Start:2015-12-10
Study Completion:2030-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03440697

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Open to external enrollment:
  2. * Subjects with a genetic diagnosis of Marfan Syndrome (MDS), Loeys-Dietz Syndrome (LDS), or Vascular Ehlers-Danlos Syndrome (EDS); (Positive genetic testing or a previous cardiac study required to be eligible)
  3. * Family members of eligible subjects (Only family members of subjects with syndromic diagnoses are eligible for external enrollment at this time)
  4. * Closed to external enrollment:
  5. * Subjects with aortic disease including TAA\* or dissection, aortic tortuosity, or aortic hypoplasia/stenosis (based on any cardiac imaging modality including echocardiography, CT, MRI, or angiography)
  6. * Subjects with aortic valve disease (bicuspid, unicuspid, or tricuspid disease)
  7. * Control subjects having tissue removed during a surgical procedure (e.g. coronary artery bypass graft surgery (CABG), cardiac transplant, etc.)
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Lindsey Helvaty, BS, BA
CONTACT
317-278-3020
lhelvaty@iu.edu
Benjamin Landis, MD
CONTACT
317-278-2808
benjland@iu.edu

Principal Investigator

Benjamin Landis, MD
PRINCIPAL_INVESTIGATOR
IU School of Medicine

Study Locations (Sites)

Childrens Healthcare of Atlanta
Atlanta, Georgia, 30329
United States
IU School of Medicine
Indianapolis, Indiana, 46202
United States

Collaborators and Investigators

Sponsor: Indiana University

  • Benjamin Landis, MD, PRINCIPAL_INVESTIGATOR, IU School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2015-12-10
Study Completion Date2030-12-31

Study Record Updates

Study Start Date2015-12-10
Study Completion Date2030-12-31

Terms related to this study

Keywords Provided by Researchers

  • Cardiac Disease
  • Cardiovascular Genetics

Additional Relevant MeSH Terms

  • Aortopathies
  • Thoracic Aortic Aneurysm
  • Aortic Valve Disease
  • Thoracic Aortic Disease
  • Thoracic Aortic Dissection
  • Thoracic Aortic Rupture
  • Ascending Aortic Disease
  • Descending Aortic Disease
  • Ascending Aortic Aneurysm
  • Descending Aortic Aneurysm
  • Marfan Syndrome
  • Loeys-Dietz Syndrome
  • Vascular Ehlers-Danlos Syndrome
  • Shprintzen-Goldberg Syndrome
  • Turner Syndrome
  • PHACE Syndrome
  • Autosomal Recessive Cutis Laxa
  • Congenital Contractural Arachnodactyly
  • Arterial Tortuosity Syndrome
  • Bicuspid Aortic Valve-Associated Aortopathy
  • Bicuspid Aortic Valve
  • Familial Thoracic Aortic Aneurysm and Aortic Dissection