RECRUITING

Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

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Conditions

Breast Cancer

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back.

Official Title

TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

Quick Facts

Study Start:2018-10-16
Study Completion:2027-12-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03488693

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:35 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients must be women with newly diagnosed histologically proven invasive carcinoma of the breast with no evidence of metastases, staged as per site standard of care.
  2. * Patients must have been treated by BCS or mastectomy with clear margins of excision. Post-mastectomy positive margins for invasive disease and/or DCIS is not allowed. Multifocal disease (i.e. the presence of two or more foci or breast cancer within the same breast quadrant) and multicentric disease (i.e. the presence of two or more foci of breast cancer in different quadrants of the same breast) are allowed.
  3. * Patients with T3N0 disease are eligible.
  4. * Patients with disease limited to nodal micrometastases are eligible
  5. * Patients with nodal macrometastases (\>2mm) treated by axillary dissection must have 1-3 positive axillary nodes (macrometastases, \> 2 mm).
  6. * Patients treated by mastectomy and SLNB alone must have only 1-2 positive axillary nodes (macrometastases, \> 2 mm).
  7. * Patients must be ER ≥ 1% and HER2 negative on local testing
  8. * Patients must have an Oncotype DX recurrence score ≤25 obtained from testing of breast tumour tissue from a core biopsy or from the surgical specimen.
  9. * Patient must consent to provision of, and investigator(s) must agree to submit to the CCTG Central Tumour Bank, a representative formalin fixed paraffin block of tumour tissue in order that the specific correlative marker assays described in the protocol may be conducted
  10. * Patient must consent to provision of samples of blood in order that the specific correlative marker assays described in the protocol may be conducted.
  11. * Patients must have had endocrine therapy initiated or planned for ≥ 5 years. Premenopausal women will receive ovarian ablation plus aromatase inhibitor therapy or tamoxifen if adjuvant chemotherapy was not administered. For all patients, endocrine therapy can be given concurrently or following RT.
  12. * Patients may or may not have had adjuvant chemotherapy.
  13. * RT must commence within 16 weeks of definitive surgery if the patient is not treated with chemotherapy. If adjuvant chemotherapy is given, RT must begin within 12 weeks after the last dose. (Note: adjuvant chemotherapy may be ongoing at the time of randomization). Definitive surgery is defined as the last breast cancer-related surgery.
  14. * Patient's ECOG performance status must be 0, 1 or 2.
  15. * Patient's age must be ≥ 35 years.
  16. * For the first 736 eligible English or French-speaking subjects who have agreed to optional questionnaire completion: Patient is able (i.e. sufficiently fluent) and willing to complete the quality of life, health utilities and lost productivity questionnaires in either English or French (note: enrollment completed 2022Aug02)
  17. * Patient consent must be appropriately obtained in accordance with applicable local and regulatory requirements
  18. * Patients must be accessible for treatment and follow-up. Investigators must assure themselves the patients randomized on this trial will be available for complete documentation of the treatment, adverse events, and follow-up.
  19. * In accordance with CCTG policy, protocol treatment is to begin within 6 weeks of patient randomization.
  20. * Women of childbearing potential must have agreed to use an effective contraceptive method. A woman is considered to be of "childbearing potential" if she has had menses at any time in the preceding 12 consecutive months.
  1. * Patients with nodal disease limited to isolated tumour cells (pN0i+ \< 0.2 mm).
  2. * Patients with pT3N1 and pT4 disease (Note: patients with T3N0 are eligible).
  3. * Any prior history, not including the index cancer, of ipsilateral invasive breast cancer or ipsilateral DCIS treated with radiation therapy. (Patients with synchronous or previous ipsilateral LCIS are eligible.)
  4. * Synchronous or previous contralateral invasive breast cancer. (Patients with contralateral DCIS are eligible unless previously treated with radiation.)
  5. * History of non-breast malignancies except adequately treated non-melanoma skin cancers, in situ cancers treated by local excision or other cancers curatively treated with no evidence of disease for ≥ 5 years.
  6. * Patients who are pregnant.
  7. * Patients that have had prior ipsilateral chestwall/thoracic radiation.
  8. * Patients treated with chemo or endocrine therapy administered in the neoadjuvant setting for breast cancer. Endocrine therapy exposure 12 weeks or less prior to surgery is permitted.
  9. * Patients with serious non-malignant disease (e.g. cardiovascular, scleroderma etc.) which would preclude RT.
  10. * Patients with any serious active or co-morbid medical conditions, laboratory abnormality, psychiatric illness, active or uncontrolled infections, or serious illnesses or medical conditions that would prevent the patient from participating or to be managed according to the protocol (according to investigator's decision).

Contacts and Locations

Study Contact

Wendy Parulekar
CONTACT
613-533-6430
wparulekar@ctg.queensu.ca

Principal Investigator

Timothy Whelan
STUDY_CHAIR
Juravinski Cancer Centre at Hamilton Health Sciences, Ontario Canada

Study Locations (Sites)

Fairbanks Memorial Hospital
Fairbanks, Alaska, 99701
United States
University of Arizona Cancer Center-Orange Grove Campus
Tucson, Arizona, 85704
United States
University of Arizona Cancer Center-North Campus
Tucson, Arizona, 85719
United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
United States
Kaiser Permanente-Anaheim
Anaheim, California, 92806
United States
Kaiser Permanente-Bellflower
Bellflower, California, 90706
United States
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, 94704
United States
City of Hope Corona
Corona, California, 92879
United States
City of Hope Comprehensive Cancer Center
Duarte, California, 91010
United States
Kaiser Permanente Dublin
Dublin, California, 94568
United States
Fresno Cancer Center
Fresno, California, 93720
United States
City of Hope at Irvine Lennar
Irvine, California, 92618
United States
UC San Diego Moores Cancer Center
La Jolla, California, 92093
United States
City of Hope Antelope Valley
Lancaster, California, 93534
United States
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, 90027
United States
Los Angeles General Medical Center
Los Angeles, California, 90033
United States
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033
United States
Providence Queen of The Valley
Napa, California, 94558
United States
Kaiser Permanente Oakland-Broadway
Oakland, California, 94611
United States
Saint Joseph Hospital - Orange
Orange, California, 92868
United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868
United States
Desert Regional Medical Center
Palm Springs, California, 92262
United States
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California, 95670
United States
Rohnert Park Cancer Center
Rohnert Park, California, 94928
United States
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, 95678
United States
Mercy Cancer Center - Sacramento
Sacramento, California, 95816
United States
Saint Helena Hospital
Saint Helena, California, 94574
United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051
United States
Saint John's Cancer Institute
Santa Monica, California, 90404
United States
City of Hope South Pasadena
South Pasadena, California, 91030
United States
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, 94080
United States
City of Hope South Bay
Torrance, California, 90503
United States
City of Hope Upland
Upland, California, 91786
United States
Sutter Solano Medical Center/Cancer Center
Vallejo, California, 94589
United States
UCHealth University of Colorado Hospital
Aurora, Colorado, 80045
United States
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, 80304
United States
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
United States
UCHealth Memorial Hospital Central
Colorado Springs, Colorado, 80909
United States
Memorial Hospital North
Colorado Springs, Colorado, 80920
United States
Saint Francis Cancer Center
Colorado Springs, Colorado, 80923
United States
UCHealth - Cherry Creek
Denver, Colorado, 80206
United States
Porter Adventist Hospital
Denver, Colorado, 80210
United States
Poudre Valley Hospital
Fort Collins, Colorado, 80524
United States
Lutheran Hospital - Cancer Centers of Colorado
Golden, Colorado, 80401
United States
Banner North Colorado Medical Center
Greeley, Colorado, 80631
United States
UCHealth Greeley Hospital
Greeley, Colorado, 80631
United States
UCHealth Highlands Ranch Hospital
Highlands Ranch, Colorado, 80129
United States
Littleton Adventist Hospital
Littleton, Colorado, 80122
United States
Banner McKee Medical Center
Loveland, Colorado, 80539
United States
Intermountain Health Lutheran Hospital
Wheat Ridge, Colorado, 80401
United States
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, 06437
United States
Smilow Cancer Hospital-Hamden Care Center
Hamden, Connecticut, 06518
United States
Yale University
New Haven, Connecticut, 06520
United States
Norwalk Hospital
Norwalk, Connecticut, 06856
United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611
United States
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385
United States
Helen F Graham Cancer Center
Newark, Delaware, 19713
United States
Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718
United States
MedStar Georgetown University Hospital
Washington, District of Columbia, 20007
United States
MedStar Washington Hospital Center
Washington, District of Columbia, 20010
United States
Sibley Memorial Hospital
Washington, District of Columbia, 20016
United States
Boca Raton Regional Hospital
Boca Raton, Florida, 33486
United States
Morton Plant Hospital
Clearwater, Florida, 33756
United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, 33146
United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, 33442
United States
Broward Health Medical Center
Fort Lauderdale, Florida, 33316
United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida, 33021
United States
Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980
United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136
United States
Miami Cancer Institute
Miami, Florida, 33176
United States
Orlando Health Cancer Institute
Orlando, Florida, 32806
United States
Memorial Hospital West
Pembroke Pines, Florida, 33028
United States
Miami Cancer Institute at Plantation
Plantation, Florida, 33324
United States
Saint Anthony's Hospital Cancer Care Center
Saint Petersburg, Florida, 33705
United States
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida, 33607
United States
Moffitt Cancer Center
Tampa, Florida, 33612
United States
Cleveland Clinic-Weston
Weston, Florida, 33331
United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, 31405
United States
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, 83814
United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854
United States
Northwestern University
Chicago, Illinois, 60611
United States
Rush University Medical Center
Chicago, Illinois, 60612
United States
University of Illinois
Chicago, Illinois, 60612
United States
Swedish Covenant Hospital
Chicago, Illinois, 60625
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
United States
Advocate Illinois Masonic Medical Center
Chicago, Illinois, 60657
United States
Decatur Memorial Hospital
Decatur, Illinois, 62526
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, 60115
United States
Crossroads Cancer Center
Effingham, Illinois, 62401
United States
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois, 60201
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134
United States
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois, 60026
United States
Ingalls Memorial Hospital
Harvey, Illinois, 60426
United States
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois, 60035
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, 60045
United States
Loyola University Medical Center
Maywood, Illinois, 60153
United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, 60451
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois, 60462
United States
Advocate Lutheran General Hospital
Park Ridge, Illinois, 60068
United States
OSF Saint Francis Medical Center
Peoria, Illinois, 61637
United States
UW Health Carbone Cancer Center Rockford
Rockford, Illinois, 61114
United States
Springfield Memorial Hospital
Springfield, Illinois, 62781
United States
Carle Cancer Center
Urbana, Illinois, 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555
United States
IU Health West Hospital
Avon, Indiana, 46123
United States
IU Health North Hospital
Carmel, Indiana, 46032
United States
IU Health Central Indiana Cancer Centers-Fishers
Fishers, Indiana, 46037
United States
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202
United States
IU Health Methodist Hospital
Indianapolis, Indiana, 46202
United States
Community Cancer Center East
Indianapolis, Indiana, 46219
United States
Community Cancer Center South
Indianapolis, Indiana, 46227
United States
Community Cancer Center North
Indianapolis, Indiana, 46256
United States
IU Health Ball Memorial Hospital
Muncie, Indiana, 47303
United States
Saint Luke's Hospital
Cedar Rapids, Iowa, 52402
United States
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325
United States
Greater Regional Medical Center
Creston, Iowa, 50801
United States
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
United States
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
United States
University of Kansas Cancer Center
Kansas City, Kansas, 66160
United States
Olathe Health Cancer Center
Olathe, Kansas, 66061
United States
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, 66210
United States
Ascension Via Christi Hospitals Wichita
Wichita, Kansas, 67214
United States
Saint Elizabeth Healthcare Edgewood
Edgewood, Kentucky, 41017
United States
Saint Elizabeth Healthcare Fort Thomas
Fort Thomas, Kentucky, 41075
United States
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky, 40504
United States
Saint Joseph Hospital East
Lexington, Kentucky, 40509
United States
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536
United States
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, 40202
United States
UofL Health Medical Center Northeast
Louisville, Kentucky, 40245
United States
Owensboro Health Mitchell Memorial Cancer Center
Owensboro, Kentucky, 42303
United States
LSU Health Sciences Center at Shreveport
Shreveport, Louisiana, 71103
United States
MaineHealth Coastal Cancer Treatment Center
Bath, Maine, 04530
United States
Lafayette Family Cancer Center-EMMC
Brewer, Maine, 04412
United States
Maine Medical Center-Bramhall Campus
Portland, Maine, 04102
United States
MaineHealth Cancer Care Center of York County
Sanford, Maine, 04073
United States
Maine Medical Center- Scarborough Campus
Scarborough, Maine, 04074
United States
Luminis Health Anne Arundel Medical Center
Annapolis, Maryland, 21401
United States
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, 21201
United States
Greater Baltimore Medical Center
Baltimore, Maryland, 21204
United States
Saint Agnes Hospital
Baltimore, Maryland, 21229
United States
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore, Maryland, 21237
United States
MedStar Good Samaritan Hospital
Baltimore, Maryland, 21239
United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287
United States
Suburban Hospital
Bethesda, Maryland, 20814
United States
University of Maryland Shore Medical Center at Easton
Easton, Maryland, 21601
United States
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie, Maryland, 21061
United States
UM Saint Joseph Medical Center
Towson, Maryland, 21204
United States
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114
United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215
United States
Lahey Hospital and Medical Center
Burlington, Massachusetts, 01805
United States
Lowell General Hospital
Lowell, Massachusetts, 01854
United States
Baystate Medical Center
Springfield, Massachusetts, 01199
United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109
United States
McLaren Cancer Institute-Bay City
Bay City, Michigan, 48706
United States
McLaren Cancer Institute-Clarkston
Clarkston, Michigan, 48346
United States
Corewell Health Dearborn Hospital
Dearborn, Michigan, 48124
United States
Corewell Health Farmington Hills Hospital
Farmington Hills, Michigan, 48336
United States
McLaren Cancer Institute-Flint
Flint, Michigan, 48532
United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, 49503
United States
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan, 49503
United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
United States
Karmanos Cancer Institute at McLaren Greater Lansing
Lansing, Michigan, 48910
United States
McLaren Cancer Institute-Macomb
Mount Clemens, Michigan, 48043
United States
Trinity Health Muskegon Hospital
Muskegon, Michigan, 49444
United States
Henry Ford Health Providence Novi Hospital
Novi, Michigan, 48374
United States
McLaren Cancer Institute-Northern Michigan
Petoskey, Michigan, 49770
United States
McLaren-Port Huron
Port Huron, Michigan, 48060
United States
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan, 48073
United States
Henry Ford Health Providence Southfield Hospital
Southfield, Michigan, 48075
United States
Munson Medical Center
Traverse City, Michigan, 49684
United States
Corewell Health Beaumont Troy Hospital
Troy, Michigan, 48085
United States
University of Michigan Health - West
Wyoming, Michigan, 49519
United States
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
United States
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
United States
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi, 38671
United States
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
United States
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, Missouri, 65212
United States
MU Health Care Goldschmidt Cancer Center
Jefferson City, Missouri, 65109
United States
University of Kansas Cancer Center - North
Kansas City, Missouri, 64154
United States
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri, 64064
United States
Missouri Baptist Medical Center
Saint Louis, Missouri, 63131
United States
Billings Clinic Cancer Center
Billings, Montana, 59101
United States
Saint James Community Hospital and Cancer Treatment Center
Butte, Montana, 59701
United States
Benefis Sletten Cancer Institute
Great Falls, Montana, 59405
United States
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
United States
University of Nebraska Medical Center
Omaha, Nebraska, 68198
United States
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada, 89106
United States
Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada, 89119
United States
New Hampshire Oncology Hematology PA-Concord
Concord, New Hampshire, 03301
United States
Wentworth-Douglass Hospital
Dover, New Hampshire, 03820
United States
Exeter Hospital
Exeter, New Hampshire, 03833
United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756
United States
Solinsky Center for Cancer Care
Manchester, New Hampshire, 03103
United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920
United States
Englewood Hospital and Medical Center
Englewood, New Jersey, 07631
United States
CentraState Medical Center
Freehold, New Jersey, 07728
United States
The Cancer Institute of New Jersey Hamilton
Hamilton, New Jersey, 08690
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748
United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645
United States
Saint Peter's University Hospital
New Brunswick, New Jersey, 08901
United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
United States
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey, 08080
United States
Robert Wood Johnson University Hospital Somerset
Somerville, New Jersey, 08876
United States
Community Medical Center
Toms River, New Jersey, 08755
United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
United States
Lovelace Radiation Oncology
Albuquerque, New Mexico, 87109
United States
New Mexico Oncology Hematology Consultants
Albuquerque, New Mexico, 87109
United States
Memorial Medical Center - Las Cruces
Las Cruces, New Mexico, 88011
United States
Mount Sinai Queens
Astoria, New York, 11102
United States
Montefiore Medical Center-Einstein Campus
Bronx, New York, 10461
United States
Montefiore Medical Center - Moses Campus
Bronx, New York, 10467
United States
New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn, New York, 11215
United States
Maimonides Medical Center
Brooklyn, New York, 11219
United States
Sands Cancer Center
Canandaigua, New York, 14424
United States
Memorial Sloan Kettering Commack
Commack, New York, 11725
United States
Mary Imogene Bassett Hospital
Cooperstown, New York, 13326
United States
Noyes Memorial Hospital/Myers Cancer Center
Dansville, New York, 14437
United States
Memorial Sloan Kettering Westchester
Harrison, New York, 10604
United States
NYU Langone Hospital - Long Island
Mineola, New York, 11501
United States
Mount Sinai Union Square
New York, New York, 10003
United States
Mount Sinai Chelsea
New York, New York, 10011
United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016
United States
Mount Sinai West
New York, New York, 10019
United States
Mount Sinai Hospital
New York, New York, 10029
United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032
United States
Memorial Sloan Kettering Cancer Center
New York, New York, 10065
United States
Nyack Hospital
Nyack, New York, 10960
United States
Wilmot Cancer Institute Radiation Oncology at Greece
Rochester, New York, 14606
United States
Highland Hospital
Rochester, New York, 14620
United States
Rochester General Hospital
Rochester, New York, 14621
United States
Pluta Cancer Center
Rochester, New York, 14623
United States
University of Rochester
Rochester, New York, 14642
United States
Stony Brook University Medical Center
Stony Brook, New York, 11794
United States
State University of New York Upstate Medical University
Syracuse, New York, 13210
United States
Memorial Sloan Kettering Nassau
Uniondale, New York, 11553
United States
Wilmot Cancer Institute at Webster
Webster, New York, 14580
United States
Mission Hospital
Asheville, North Carolina, 28801
United States
Hope Women's Cancer Centers-Asheville
Asheville, North Carolina, 28816
United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599
United States
Duke University Medical Center
Durham, North Carolina, 27710
United States
CaroMont Regional Medical Center
Gastonia, North Carolina, 28054
United States
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina, 28791
United States
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501
United States
Altru Cancer Center
Grand Forks, North Dakota, 58201
United States
Cleveland Clinic Akron General
Akron, Ohio, 44307
United States
UH Seidman Cancer Center at UH Avon Health Center
Avon, Ohio, 44011
United States
UHHS-Chagrin Highlands Medical Center
Beachwood, Ohio, 44122
United States
Cleveland Clinic Mercy Hospital
Canton, Ohio, 44708
United States
Aultman Health Foundation
Canton, Ohio, 44710
United States
Geauga Hospital
Chardon, Ohio, 44024
United States
Case Western Reserve University
Cleveland, Ohio, 44106
United States
MetroHealth Medical Center
Cleveland, Ohio, 44109
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
United States
Riverside Methodist Hospital
Columbus, Ohio, 43214
United States
Grant Medical Center
Columbus, Ohio, 43215
United States
The Mark H Zangmeister Center
Columbus, Ohio, 43219
United States
Delaware Health Center-Grady Cancer Center
Delaware, Ohio, 43015
United States
Dublin Methodist Hospital
Dublin, Ohio, 43016
United States
Mercy Cancer Center-Elyria
Elyria, Ohio, 44035
United States
Mount Carmel Grove City Hospital
Grove City, Ohio, 43123
United States
OhioHealth Mansfield Hospital
Mansfield, Ohio, 44903
United States
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor, Ohio, 44060
United States
UH Seidman Cancer Center at Southwest General Hospital
Middleburg Heights, Ohio, 44130
United States
University Hospitals Parma Medical Center
Parma, Ohio, 44129
United States
Mercy Health Perrysburg Cancer Center
Perrysburg, Ohio, 43551
United States
University Hospitals Portage Medical Center
Ravenna, Ohio, 44266
United States
UH Seidman Cancer Center at Firelands Regional Medical Center
Sandusky, Ohio, 44870
United States
ProMedica Flower Hospital
Sylvania, Ohio, 43560
United States
University Hospitals Sharon Health Center
Wadsworth, Ohio, 44281
United States
Saint Ann's Hospital
Westerville, Ohio, 43081
United States
UH Seidman Cancer Center at Saint John Medical Center
Westlake, Ohio, 44145
United States
UHHS-Westlake Medical Center
Westlake, Ohio, 44145
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
United States
Saint Charles Health System
Bend, Oregon, 97701
United States
Good Samaritan Hospital
Corvallis, Oregon, 97330
United States
Oregon Health and Science University
Portland, Oregon, 97239
United States
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, 19010
United States
Carlisle Regional Cancer Center
Carlisle, Pennsylvania, 17015
United States
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, 19317
United States
Ephrata Cancer Center
Ephrata, Pennsylvania, 17522
United States
UPMC Hillman Cancer Center Erie
Erie, Pennsylvania, 16505
United States
Saint Vincent Hospital
Erie, Pennsylvania, 16544
United States
UPMC Cancer Center at UPMC Horizon
Farrell, Pennsylvania, 16121
United States
Adams Cancer Center
Gettysburg, Pennsylvania, 17325
United States
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg, Pennsylvania, 15601
United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania, 17109
United States
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, 17033-0850
United States
IRMC Cancer Center
Indiana, Pennsylvania, 15701
United States
Jefferson Hospital
Jefferson Hills, Pennsylvania, 15025
United States
Lancaster General Ann B Barshinger Cancer Institute
Lancaster, Pennsylvania, 17601
United States
Lancaster General Hospital
Lancaster, Pennsylvania, 17602
United States
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg, Pennsylvania, 17050
United States
Riddle Memorial Hospital
Media, Pennsylvania, 19063
United States
Forbes Hospital
Monroeville, Pennsylvania, 15146
United States
UPMC Cancer Center - Monroeville
Monroeville, Pennsylvania, 15146
United States
Bryn Mawr Health Center
Newtown Square, Pennsylvania, 19073
United States
Paoli Memorial Hospital
Paoli, Pennsylvania, 19301
United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
United States
Jefferson Torresdale Hospital
Philadelphia, Pennsylvania, 19114
United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
United States
UPMC-Magee Womens Hospital
Pittsburgh, Pennsylvania, 15213
United States
UPMC-Saint Margaret
Pittsburgh, Pennsylvania, 15215
United States
West Penn Hospital
Pittsburgh, Pennsylvania, 15224
United States
UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania, 15232
United States
UPMC-Passavant Hospital
Pittsburgh, Pennsylvania, 15237
United States
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh, Pennsylvania, 15243
United States
Penn State Health Saint Joseph Medical Center
Reading, Pennsylvania, 19605
United States
UPMC Washington Hospital Radiation Oncology
Washington, Pennsylvania, 15301
United States
Reading Hospital
West Reading, Pennsylvania, 19611
United States
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania, 15090
United States
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania, 19090
United States
Lankenau Medical Center
Wynnewood, Pennsylvania, 19096
United States
WellSpan Health-York Cancer Center
York, Pennsylvania, 17403
United States
UPMC Memorial
York, Pennsylvania, 17408
United States
Women and Infants Hospital
Providence, Rhode Island, 02905
United States
Kent Hospital
Warwick, Rhode Island, 02886
United States
Saint Joseph's/Candler - Bluffton Campus
Bluffton, South Carolina, 29910
United States
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, 29316
United States
Medical University of South Carolina
Charleston, South Carolina, 29425
United States
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605
United States
Saint Francis Cancer Center
Greenville, South Carolina, 29607
United States
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615
United States
Self Regional Healthcare
Greenwood, South Carolina, 29646
United States
Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650
United States
The Radiation Oncology Center-Hilton Head/Bluffton
Hilton Head Island, South Carolina, 29926
United States
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672
United States
Spartanburg Medical Center
Spartanburg, South Carolina, 29303
United States
Lexington Medical Center
West Columbia, South Carolina, 29169
United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee, 38120
United States
Houston Methodist San Jacinto Hospital
Baytown, Texas, 77521
United States
MD Anderson in The Woodlands
Conroe, Texas, 77384
United States
Parkland Memorial Hospital
Dallas, Texas, 75235
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
United States
University of Texas Medical Branch
Galveston, Texas, 77555-0565
United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030
United States
Ben Taub General Hospital
Houston, Texas, 77030
United States
Houston Methodist Hospital
Houston, Texas, 77030
United States
M D Anderson Cancer Center
Houston, Texas, 77030
United States
Methodist Willowbrook Hospital
Houston, Texas, 77070
United States
MD Anderson West Houston
Houston, Texas, 77079
United States
Houston Methodist West Hospital
Houston, Texas, 77094
United States
Doctor's Hospital of Laredo
Laredo, Texas, 78041
United States
MD Anderson League City
League City, Texas, 77573
United States
Houston Methodist Saint John Hospital
Nassau Bay, Texas, 77058
United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229
United States
MD Anderson in Sugar Land
Sugar Land, Texas, 77478
United States
Houston Methodist Sugar Land Hospital
Sugar Land, Texas, 77479
United States
Houston Methodist The Woodlands Hospital
The Woodlands, Texas, 77385
United States
American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork, Utah, 84003
United States
Sandra L Maxwell Cancer Center
Cedar City, Utah, 84720
United States
Farmington Health Center
Farmington, Utah, 84025
United States
Logan Regional Hospital
Logan, Utah, 84321
United States
Intermountain Medical Center
Murray, Utah, 84107
United States
McKay-Dee Hospital Center
Ogden, Utah, 84403
United States
Utah Valley Regional Medical Center
Provo, Utah, 84604
United States
Riverton Hospital
Riverton, Utah, 84065
United States
Saint George Regional Medical Center
Saint George, Utah, 84770
United States
University of Utah Sugarhouse Health Center
Salt Lake City, Utah, 84106
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112
United States
LDS Hospital
Salt Lake City, Utah, 84143
United States
South Jordan Health Center
South Jordan, Utah, 84009
United States
Central Vermont Medical Center/National Life Cancer Treatment
Berlin, Vermont, 05602
United States
University of Vermont Medical Center
Burlington, Vermont, 05401
United States
Dartmouth Cancer Center - North
Saint Johnsbury, Vermont, 05819
United States
Augusta Health Center for Cancer and Blood Disorders
Fishersville, Virginia, 22939
United States
Naval Medical Center - Portsmouth
Portsmouth, Virginia, 23708-2197
United States
CJW Medical Center - Johnston-Willis Campus
Richmond, Virginia, 23235
United States
MultiCare Auburn Medical Center
Auburn, Washington, 98001
United States
MultiCare Gig Harbor Medical Park
Gig Harbor, Washington, 98335
United States
Swedish Medical Center-First Hill
Seattle, Washington, 98122
United States
MultiCare Tacoma General Hospital
Tacoma, Washington, 98405
United States
West Virginia University Healthcare
Morgantown, West Virginia, 26506
United States
Langlade Hospital and Cancer Center
Antigo, Wisconsin, 54409
United States
ThedaCare Regional Cancer Center
Appleton, Wisconsin, 54911
United States
HSHS Sacred Heart Hospital
Eau Claire, Wisconsin, 54701
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
United States
Aurora Cancer Care-Grafton
Grafton, Wisconsin, 53024
United States
Bellin Memorial Hospital
Green Bay, Wisconsin, 54301
United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301
United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, 54303
United States
Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311
United States
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek, Wisconsin, 53038
United States
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, 53142
United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
United States
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792
United States
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, 54143
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin, 53051
United States
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215
United States
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
United States
Aurora Sinai Medical Center
Milwaukee, Wisconsin, 53233
United States
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548
United States
ProHealth D N Greenwald Center
Mukwonago, Wisconsin, 53149
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
United States
Drexel Town Square Health Center
Oak Creek, Wisconsin, 53154
United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
United States
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, 54904
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
United States
HSHS Saint Nicholas Hospital
Sheboygan, Wisconsin, 53081
United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, 53081
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482
United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235-1495
United States
Aurora Medical Center in Summit
Summit, Wisconsin, 53066
United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, 54241
United States
Aspirus Regional Cancer Center
Wausau, Wisconsin, 54401
United States
Aurora West Allis Medical Center
West Allis, Wisconsin, 53227
United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin, 53095
United States
Diagnostic and Treatment Center
Weston, Wisconsin, 54476
United States
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476
United States
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin, 54494
United States

Collaborators and Investigators

Sponsor: Canadian Cancer Trials Group

  • Timothy Whelan, STUDY_CHAIR, Juravinski Cancer Centre at Hamilton Health Sciences, Ontario Canada

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-10-16
Study Completion Date2027-12-30

Study Record Updates

Study Start Date2018-10-16
Study Completion Date2027-12-30

Terms related to this study

Additional Relevant MeSH Terms

  • Breast Cancer