RECRUITING

UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic amyloid deposition using the PET tracer \[C-11\]PiB in participants in the UAB Alzheimer's Disease Center cohort. Assessment of interactions between race and vascular risk factors, brain amyloid levels measured with \[C-11\]PiB-PET, and cognitive status will be the primary outcome of this imaging study.

Official Title

UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy

Quick Facts

Study Start:2018-04-20
Study Completion:2026-04-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03503331

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 2. Negative urine or serum B-hCG test within 2 days of \[C-11\]PiB administration in women of child bearing potential. Women who are post-menopausal with at least 1 year since last menses or documented surgical sterilization will not require pregnancy testing.
  1. 1. Meets any exclusion criteria for the UAB-ADC study (IRB-300000169).
  2. 2. Inability or contraindication for undergoing MRI and/or PET imaging
  3. 3. Inability to participate in the imaging studies due to severity of dementia

Contacts and Locations

Study Contact

Chinara Dosse
CONTACT
(205) 975-7017
cdosse@uabmc.edu
Evan Hudson
CONTACT
205-934-6499
evanhudson@uabmc.edu

Principal Investigator

Jonathan McConathy, MD
PRINCIPAL_INVESTIGATOR
University of Alabama at Birmingham

Study Locations (Sites)

University of Alabama at Birmingham Medical Center
Birmingham, Alabama, 35294
United States

Collaborators and Investigators

Sponsor: University of Alabama at Birmingham

  • Jonathan McConathy, MD, PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-04-20
Study Completion Date2026-04-01

Study Record Updates

Study Start Date2018-04-20
Study Completion Date2026-04-01

Terms related to this study

Additional Relevant MeSH Terms

  • Alzheimer Disease