RECRUITING

The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Patients who tear their ACL are at high risk for developing arthritis (post-traumatic osteoarthritis-PTOA) just 10 years later. Joint bleeding and inflammation contribute to deterioration of joint health. This study will determine whether treatment with Tranexamic Acid (TXA), an FDA approved medication that reduces bleeding right after ACL injury and reconstructive surgery reduces inflammation and improves joint health as a new strategy to prevent or delay the onset of PTOA.

Official Title

Novel Strategies to Combat Post-Traumatic Osteoarthritis (PTOA):The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients

Quick Facts

Study Start:2019-08-01
Study Completion:2025-01-14
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03552705

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 30 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * age 18-30 years
  2. * within 4 days of unilateral ACL injury
  3. * presence of effusion/hemarthrosis.
  1. * inflammatory arthritis, radiographic osteoarthritis (K-L Grade 2 or higher), gout/ pseudogout
  2. * systemic or acute illness requiring medications
  3. * concomitant knee injury aside from meniscus tear and MCL tear not requiring surgery
  4. * prior surgery to either knee
  5. * prior injury to either knee requiring crutches
  6. * history of thromboembolic disease
  7. * current use of combination hormonal contraception
  8. * chronic NSAID use
  9. * cortisone injection to either knee within the prior 3 months
  10. * not indicated for or unable to undergo ACLR within 3 months of injury

Contacts and Locations

Study Contact

Christine L Hoang, BS
CONTACT
650-721-7612
c1hoang@stanford.edu

Principal Investigator

Constance Chu, MD
PRINCIPAL_INVESTIGATOR
Stanford University

Study Locations (Sites)

Stanford University
Stanford, California, 94305
United States

Collaborators and Investigators

Sponsor: Stanford University

  • Constance Chu, MD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-08-01
Study Completion Date2025-01-14

Study Record Updates

Study Start Date2019-08-01
Study Completion Date2025-01-14

Terms related to this study

Additional Relevant MeSH Terms

  • Anterior Cruciate Ligament Reconstruction