COMPLETED

VLU Dressing Study

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of the study is to investigate the effectiveness of Cutimed Sorbact (Study Device) in modifying bacterial load in venous leg ulcers (VLU).

Official Title

An Exploratory, Single Center, Observer Masked, Active Control, Randomized Trial to Investigate the Effectiveness of Dialkylcarbomoyl Chloride Dressing (Cutimed Sorbact) in Modifying Bacterial Load in Venous Leg Ulcers (VLU)

Quick Facts

Study Start:2018-08-22

Study Completion:2023-11-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:COMPLETED

Study ID

NCT03621592

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Adults, 18 years old and older (i.e. age ≥ 18 years). 2. Venous leg ulcer (VLU) is present on the leg. VLU shall be full thickness but without exposure of deeper tissues (muscle bone or tendon). 3. If more than one ulcer is present, the largest ulcer meeting criteria shall be designated the study ulcer. 4. If more than one ulcer on the study ulcer limb, study ulcer shall be at least one centimeter from other ulcers. 5. Venous Doppler ultrasound exam, within one year from randomization, shall demonstrate reflux of over 0.5 seconds in the affected limb. 6. Ankle-Brachial Pressure Index (ABI) exam with value of ≥0.80 in the affected limb 7. VLU has been treated with silver based therapy for at least 2 weeks within the previous 6 months. 8. VLU present for at least one month prior to screening visit 1. 9. VLU at least 2 cm2 in size but not larger than 100 cm2. 10. After debridement, study ulcer demonstrates a clean wound bed. 11. If subject is a female of childbearing potential, subject must use at least one method of contraception acceptable by PI such as birth control pills, Intrauterine Device (IUD), condoms, or sexual abstinence. At visit 1 urine pregnancy test must be negative. 12. Subject is able to comprehend all study related procedures and adhere to study schedule. 13. Subject is able to provide written informed consent.	1. Based on investigator medical judgment, ulcer is caused by any etiology exclusive of venous insufficiency. 2. Study Ulcer surface area (post-debridement) has increased or decreased by more than 30% in the period between screening visit 1 and treatment visit 1. 3. Study Ulcer exhibits clinical signs and symptoms of infection in the period between screening visit 1 and treatment visit 1 requiring oral antibacterial therapy. 4. Subject has known allergy to any of the materials used in the study. 5. Subject is unable to tolerate multi-layer compression therapy. 6. Based on investigator medical judgment, the Study Ulcer is suspicious for cancer (e.g. basal cell carcinoma or squamous cell carcinoma). 7. In the month prior to screening visit 1 subject was treated with systemic immunosuppressive medications for more than 2 weeks (e.g. chemotherapy, corticosteroids), and/or it is anticipated subject will require such medications during study period. 8. In the month prior to screening visit 1 subject was enrolled in any other research protocol for treatment of Study Ulcer. 9. The Subject has been diagnosed with malignant disease not in remission over the 5 years immediately preceding screening visit 1. (Except: cervical carcinoma in situ, cutaneous squamous cell carcinoma, cutaneous basal cell carcinoma that have been treated and have no evidence of recurrence or metastases). 10. Study ulcer area has been treated with radiation therapy at any time. 11. In the opinion of PI the subject has a medical condition such as autoimmune, renal, hepatic or hematologic disease that makes the subject an inappropriate candidate for participation in study. 12. In the month preceding screening visit 1 Study Ulcer has been treated with advanced tissue engineered devices matrix based devices (e.g., Apligraf, Dermagraft, Oasis). 13. Subject is diagnosed with New York Heart Association Class III and IV congestive heart. 14. Failure: Class III: Symptoms with moderate exertion or, Class IV: Symptoms at rest. 15. Subject is diagnosed with diabetes mellitus that is poorly controlled and shall be defined as hemoglobin A1C \>10%. 16. Study Ulcer is completely or more than 50% of the Study Ulcer is located on the foot (i.e. below the malleolus). 17. Subject is a female of childbearing potential, and refusing to use at least one method of contraception acceptable by PI such as birth control pills, IUD, condoms, or sexual abstinence. 18. Positive pregnancy test in screening visit 1 in a female of childbearing potential or active pregnancy or breast-feeding. 19. In the opinion of the PI the subject is unable to understand or comply with study related protocol including but not limited to providing informed consent.

Inclusion Criteria

Exclusion Criteria

1. Adults, 18 years old and older (i.e. age ≥ 18 years).
2. Venous leg ulcer (VLU) is present on the leg. VLU shall be full thickness but without exposure of deeper tissues (muscle bone or tendon).
3. If more than one ulcer is present, the largest ulcer meeting criteria shall be designated the study ulcer.
4. If more than one ulcer on the study ulcer limb, study ulcer shall be at least one centimeter from other ulcers.
5. Venous Doppler ultrasound exam, within one year from randomization, shall demonstrate reflux of over 0.5 seconds in the affected limb.
6. Ankle-Brachial Pressure Index (ABI) exam with value of ≥0.80 in the affected limb
7. VLU has been treated with silver based therapy for at least 2 weeks within the previous 6 months.
8. VLU present for at least one month prior to screening visit 1.
9. VLU at least 2 cm2 in size but not larger than 100 cm2.
10. After debridement, study ulcer demonstrates a clean wound bed.
11. If subject is a female of childbearing potential, subject must use at least one method of contraception acceptable by PI such as birth control pills, Intrauterine Device (IUD), condoms, or sexual abstinence. At visit 1 urine pregnancy test must be negative.
12. Subject is able to comprehend all study related procedures and adhere to study schedule.
13. Subject is able to provide written informed consent.

1. Based on investigator medical judgment, ulcer is caused by any etiology exclusive of venous insufficiency.
2. Study Ulcer surface area (post-debridement) has increased or decreased by more than 30% in the period between screening visit 1 and treatment visit 1.
3. Study Ulcer exhibits clinical signs and symptoms of infection in the period between screening visit 1 and treatment visit 1 requiring oral antibacterial therapy.
4. Subject has known allergy to any of the materials used in the study.
5. Subject is unable to tolerate multi-layer compression therapy.
6. Based on investigator medical judgment, the Study Ulcer is suspicious for cancer (e.g. basal cell carcinoma or squamous cell carcinoma).
7. In the month prior to screening visit 1 subject was treated with systemic immunosuppressive medications for more than 2 weeks (e.g. chemotherapy, corticosteroids), and/or it is anticipated subject will require such medications during study period.
8. In the month prior to screening visit 1 subject was enrolled in any other research protocol for treatment of Study Ulcer.
9. The Subject has been diagnosed with malignant disease not in remission over the 5 years immediately preceding screening visit 1. (Except: cervical carcinoma in situ, cutaneous squamous cell carcinoma, cutaneous basal cell carcinoma that have been treated and have no evidence of recurrence or metastases).
10. Study ulcer area has been treated with radiation therapy at any time.
11. In the opinion of PI the subject has a medical condition such as autoimmune, renal, hepatic or hematologic disease that makes the subject an inappropriate candidate for participation in study.
12. In the month preceding screening visit 1 Study Ulcer has been treated with advanced tissue engineered devices matrix based devices (e.g., Apligraf, Dermagraft, Oasis).
13. Subject is diagnosed with New York Heart Association Class III and IV congestive heart.
14. Failure: Class III: Symptoms with moderate exertion or, Class IV: Symptoms at rest.
15. Subject is diagnosed with diabetes mellitus that is poorly controlled and shall be defined as hemoglobin A1C \>10%.
16. Study Ulcer is completely or more than 50% of the Study Ulcer is located on the foot (i.e. below the malleolus).
17. Subject is a female of childbearing potential, and refusing to use at least one method of contraception acceptable by PI such as birth control pills, IUD, condoms, or sexual abstinence.
18. Positive pregnancy test in screening visit 1 in a female of childbearing potential or active pregnancy or breast-feeding.
19. In the opinion of the PI the subject is unable to understand or comply with study related protocol including but not limited to providing informed consent.

Contacts and Locations

Principal Investigator

Hadar Lev-Tov, MD

PRINCIPAL_INVESTIGATOR

University of Miami

Study Locations (Sites)

University of Miami

Miami, Florida, 33136

United States

Collaborators and Investigators

Sponsor: University of Miami

Hadar Lev-Tov, MD, PRINCIPAL_INVESTIGATOR, University of Miami

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-08-22

Study Completion Date2023-11-01

Study Record Updates

Study Start Date2018-08-22

Study Completion Date2023-11-01

Terms related to this study

Additional Relevant MeSH Terms

Venous Leg Ulcer