RECRUITING

Influence of Obesity on Endogenous Oxalate Synthesis

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

There is increasing evidence that obesity is associated with increased urinary oxalate excretion, an important risk factor for calcium oxalate stone formation. By the administration of a controlled low oxalate diet the investigators will estimate endogenous oxalate synthesis in both non-obese and obese non-kidney-stone forming adults. This study seeks to thusly increase the understanding of the relationships between obesity and endogenous oxalate synthesis to serve as a platform to develop novel therapies for stone prevention.

Official Title

Influence of Obesity on Endogenous Oxalate Synthesis

Quick Facts

Study Start:2019-05-24
Study Completion:2025-08-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03704350

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 60 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 25-60 years
  2. * Body Mass Index (BMI) \<50
  1. * history of kidney stones
  2. * history of diabetes, hepatic disease, renal disease including Chronic Kidney Disease (CKD), bowel disease or other endocrine disorders
  3. * pregnant or lactating women, or those with the intention to become pregnant in the near future
  4. * abnormal liver enzymes
  5. * hemoglobin A1C \> 6.5

Contacts and Locations

Study Contact

Sonia Fargue, MD PhD
CONTACT
205-934-0169
sfargue@uab.edu

Principal Investigator

Dean Assimos, MD
PRINCIPAL_INVESTIGATOR
University of Alabama at Birmingham

Study Locations (Sites)

University of Alabama at Birmingham
Birmingham, Alabama, 35233
United States

Collaborators and Investigators

Sponsor: University of Alabama at Birmingham

  • Dean Assimos, MD, PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-05-24
Study Completion Date2025-08-01

Study Record Updates

Study Start Date2019-05-24
Study Completion Date2025-08-01

Terms related to this study

Additional Relevant MeSH Terms

  • Kidney Stone