RECRUITING

Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.

Description

This study will use brain Positron Emission Tomography/ Magnetic Resonance Imaging (PET/MRI) and an investigational radioactive drug called \[Zr-89\]oxine to track the location of white blood cells (also called leukocytes) in the body. PET/MRI will be used to visualize labeled white blood cells and determine if they enter the central nervous system in conditions associated with brain inflammation (also called neuroinflammation). By better understanding the role of neuroinflammation in fibromyalgia, chronic fatigue syndrome, and multiple sclerosis, the investigator hopes to be able to better diagnose and treat patients in the future.

Conditions

FibromyalgiaChronic Fatigue SyndromeMultiple SclerosisHealthy
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Related Conditions:

FibromyalgiaChronic Fatigue SyndromeMultiple SclerosisHealthy

Study Overview

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Study Details

Study overview

This study will use brain Positron Emission Tomography/ Magnetic Resonance Imaging (PET/MRI) and an investigational radioactive drug called \[Zr-89\]oxine to track the location of white blood cells (also called leukocytes) in the body. PET/MRI will be used to visualize labeled white blood cells and determine if they enter the central nervous system in conditions associated with brain inflammation (also called neuroinflammation). By better understanding the role of neuroinflammation in fibromyalgia, chronic fatigue syndrome, and multiple sclerosis, the investigator hopes to be able to better diagnose and treat patients in the future.

Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.

Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.

Condition
Fibromyalgia
Intervention / Treatment

-

Contacts and Locations

Birmingham

UAB, Birmingham, Alabama, United States, 35294

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1.18 to 65 years of age 2.Healthy volunteer OR
  • * Clinical diagnosis of Multiple Sclerosis (MS) OR
  • * Meets 2016 American College of Rheumatology (ACR) case definition criteria for fibromyalgia OR
  • * Meets 1994 Fukuda case definition criteria for Chronic Fatigue Syndrome
  • 1. Contraindication to MRI
  • 2. Pregnancy
  • 3. Lactation
  • 4. Individuals who are unable to participate in the imaging portion due to severity of their medical condition
  • 5. Chronic infectious disease (e.g. HIV, HCV)
  • 6. Viral or bacterial illness requiring medical attention and/or antibiotics within 1 month of study participation
  • 7. Diagnosis of cancer, including leukemia
  • 8. Blood or blood clotting disorder
  • 9. Except for individuals with MS, a diagnosis of autoimmune disease is exclusionary
  • 10. Positive urine pregnancy test day of procedure or a serum pregnancy test within 48 hours prior to the administration of Zirconium-89 Oxinate-4-labeled leukocytes
  • 11. Currently enrolled in a clinical trial utilizing experimental therapies
  • 12. Contraindication to gadolinium based contrast agents

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Alabama at Birmingham,

Jonathan McConathy, MD,PhD, PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

2028-10