RECRUITING

Break Wave(TM) Extracorporeal Lithotripter First-in-Human Study

Description

This is a prospective, open-label, multi-center, single-arm (non-randomized) study to assess the safety and effectiveness of breaking stones in the upper urinary tract using the SonoMotion Break Wave technology. Up to 30 subjects will be included. The procedure will be performed in a hospital surgical environment as an outpatient (without being admitted) or in a non-surgical environment such as a clinic or office procedure room. The procedure will be performed under varying levels of anesthesia ranging from no anesthesia to general anesthesia (fully asleep). Stones will be limited to ≤ 10 mm for lower pole stones and ≤ 20 mm everywhere else. Safety will be measured by the self-reported occurrences of adverse events, unplanned emergency department or clinic visits, and the need for further intervention. Fragmentation will be measured by self-reported stone passage and a comparison of computed tomography (CT) images before and after the procedure.

Study Overview

Study Details

Study overview

This is a prospective, open-label, multi-center, single-arm (non-randomized) study to assess the safety and effectiveness of breaking stones in the upper urinary tract using the SonoMotion Break Wave technology. Up to 30 subjects will be included. The procedure will be performed in a hospital surgical environment as an outpatient (without being admitted) or in a non-surgical environment such as a clinic or office procedure room. The procedure will be performed under varying levels of anesthesia ranging from no anesthesia to general anesthesia (fully asleep). Stones will be limited to ≤ 10 mm for lower pole stones and ≤ 20 mm everywhere else. Safety will be measured by the self-reported occurrences of adverse events, unplanned emergency department or clinic visits, and the need for further intervention. Fragmentation will be measured by self-reported stone passage and a comparison of computed tomography (CT) images before and after the procedure.

A Study of the SonoMotion Break Wave(TM) System for the Comminution of Urinary Tract Stones

Break Wave(TM) Extracorporeal Lithotripter First-in-Human Study

Condition
Renal Calculi
Intervention / Treatment

-

Contacts and Locations

San Diego

University of California San Diego Health, San Diego, California, United States, 92103

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94143

Seattle

University of Washington Medical Center, Seattle, Washington, United States, 98195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Individuals presenting with at least one kidney stone apparent on CT.
  • * Stones must be within the upper urinary tract.
  • * Stones are indicated for SWL treatment per the American Urology Association (AUA) 2016 guidelines.8
  • * Stones must be measured under CT to be within the AUA 2016 SWL guidelines (i.e. ≤ 10 mm for lower pole stones and ≤ 20 mm for non-lower pole stones).
  • * Acute untreated urinary tract infection or urosepsis.
  • * Uncorrected bleeding disorders or coagulopathies.
  • * Pregnancy.
  • * Uncorrected obstruction distal to the stone.
  • * Patients receiving anticoagulants and who are unable or not willing to cease the medication for the Break Wave procedure.
  • * Stones that are not echogenically visible or cannot be positioned within the Break Wave therapy focus.
  • * Individuals belonging to a vulnerable group (pregnant, mentally disabled, prisoner, etc.).
  • * Patients unwilling to comply with the follow-up protocol, including post-procedure CT.
  • * Individuals under 18 years of age.
  • * Anatomic presentations preventing adequate positioning or delivery of the Break Wave pulse.
  • * Calcified abdominal aortic aneurysms or calcified renal artery aneurysms.
  • * Solitary kidney
  • * Comorbidity risks which, in at the discretion of the physician, would make the patient a poor candidate for the Break Wave procedure, such as anatomical anomalies that may not be conducive to adequate stone fragment passage.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

SonoMotion,

Study Record Dates

2027-03-30