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Intravital Microscopy in Human Solid Tumors

Description

This study will investigate the tumor-associated vasculature of patients with solid tumors. The investigators will use a technology known as intravital microscopy (IVM) in order to visualize in real-time the vessels associated with solid tumors. The IVM observations may determine if an individual patient's tumor vessels would be amenable to receiving systemic therapy, based on the functionality of the vessels.

Conditions

Solid Tumor, AdultClinical Stage IV Gastric Cancer AJCC v8Malignant Solid NeoplasmMetastatic Colorectal CarcinomaMetastatic Gastric CarcinomaMetastatic Primary Malignant Brain NeoplasmMetastatic SarcomaPostneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8Resectable Colorectal CarcinomaResectable Liver and Intrahepatic Bile Duct CarcinomaResectable Pancreatic CarcinomaResectable SarcomaStage IV Colorectal Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Malignant Brain NeoplasmMetastatic Breast CarcinomaMetastatic Liver CarcinomaMetastatic Pancreatic CarcinomaResectable Brain NeoplasmResectable Breast CarcinomaResectable Gastric CarcinomaStage IV Hepatocellular Carcinoma AJCC v8Stage IV Pancreatic Cancer AJCC v8
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Related Conditions:

Solid Tumor, AdultClinical Stage IV Gastric Cancer AJCC v8Malignant Solid NeoplasmMetastatic Colorectal CarcinomaMetastatic Gastric CarcinomaMetastatic Primary Malignant Brain NeoplasmMetastatic SarcomaPostneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8Resectable Colorectal CarcinomaResectable Liver and Intrahepatic Bile Duct CarcinomaResectable Pancreatic CarcinomaResectable SarcomaStage IV Colorectal Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Malignant Brain NeoplasmMetastatic Breast CarcinomaMetastatic Liver CarcinomaMetastatic Pancreatic CarcinomaResectable Brain NeoplasmResectable Breast CarcinomaResectable Gastric CarcinomaStage IV Hepatocellular Carcinoma AJCC v8Stage IV Pancreatic Cancer AJCC v8

Study Overview

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Study Details

Study overview

This study will investigate the tumor-associated vasculature of patients with solid tumors. The investigators will use a technology known as intravital microscopy (IVM) in order to visualize in real-time the vessels associated with solid tumors. The IVM observations may determine if an individual patient's tumor vessels would be amenable to receiving systemic therapy, based on the functionality of the vessels.

Intravital Microscopy (IVM) in Human Solid Tumors

Intravital Microscopy in Human Solid Tumors

Condition
Solid Tumor, Adult
Intervention / Treatment

-

Contacts and Locations

Jacksonville

Mayo Clinic Florida, Jacksonville, Florida, United States, 32224

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥ 18 years of age
  • * Eastern Cooperative Oncology Group (ECOG)Performance Status of ≤ 2
  • * Measurable tumor by direct visualization requiring surgical resection in the operating room (OR)
  • * Tumor types of origin include gastric, pancreatic, hepatobiliary, colorectal, sarcoma, brain, or breast cancer that may involve the axillary lymph nodes cancers. Tumors may be primary or metastatic
  • * Subject must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent
  • * Subject must have a skin prick test pre-operatively (at the time of the preoperative visit and after signed informed consent for entry into this clinical trial is given) to determine any sensitivity to fluorescein
  • * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations
  • * Renal dysfunction as defined as a glomerular filtration rate (GFR) \< 45
  • * Liver dysfunction as defined by Child-Pugh score \> 5, or liver function test (LFT)'s 1.5 x above normal range
  • * Any known allergy or prior reaction to fluorescein or a positive skin prick test to fluorescein
  • * Pregnant or nursing female subjects, determined preoperatively with a urine pregnancy test
  • * Unwilling or unable to follow protocol requirements
  • * Any condition which in the investigators' opinion deems the patient unsuitable (e.g., abnormal electrocardiography \[EKG\], including T wave inversion, elevated T waves, prolonged QRS interval, or conduction blocks) or that requires further work-up (including cardiac echo or stress test)
  • * Any condition that excludes surgical resection as the standard of care for the patient

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Emmanuel M Gabriel, M.D., Ph.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2026-05-30