RECRUITING

Detection and Amelioration of Gamma Oscillation Abnormalities in Blast-Related Brain Injury

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Combat Veterans of post-9/11 conflicts have experienced serious cognitive and emotional problems resulting from exposure to blasts. Recent work suggests that a critical factor influencing the consequences of blast exposure is distance from the blast, rather than the presence or absence of concussion symptoms. Exposure to blasts from a distance of \<10 m has been associated with significantly greater cognitive and neural problems than exposure to blasts from \>10 m. So far, the effects of blast-related brain injury on the brain are poorly understood, as to date the effects of blast exposure have received little research focus. The investigators propose to use oscillations in the gamma band (30-100 Hz) of the electroencephalogram (EEG; brain waves) to detect and remediate neural circuit dysfunction related to blast injury in Veterans. If successful, this project could lead to new approaches to detect and remediate the effects of blast exposure on Veterans and aid in their functional recovery.

Official Title

Detection and Amelioration of Gamma Oscillation Abnormalities in Blast-Related Brain Injury

Quick Facts

Study Start:2019-12-02
Study Completion:2027-07-29
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03836976

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Research participants will be 50 veterans
  2. * Ages 18-65 years
  3. * Have experienced blast exposure
  4. * Recruited from the VA Translational Research Center for TBI and Stress Disorders (TRACTS) at the VA Boston Healthcare System (VABHS)
  5. * Half of the participants will have experienced blast exposure from a Close distance (\<10 m)
  6. * Half of the participants will have experienced blast exposure from a Far distance (\>10 m)
  7. * These groups will be matched on age and female/male ratio
  1. * History of neurological illness
  2. * Huntington's
  3. * Parkinson's
  4. * dementia, etc
  5. * History of seizure disorders unrelated to head injury
  6. * Current diagnosis of schizophrenia, bipolar, or other psychotic disorder
  7. * Self-reported severe depression or anxiety requiring hospitalization overnight, or current active homicidal and/or suicidal ideation with intent requiring crisis intervention
  8. * Cognitive disorder due to general medical condition other than TBI
  9. * Unstable psychological diagnosis (suspected psychotic or personality disorder) that would interfere with accurate data collection, determined by consensus of at least three doctoral-level psychologists.
  10. * Current alcohol or drug dependence, or abuse within the last 6 months (DSM-IV criteria)
  11. * Hearing impairments as assessed by audiometry

Contacts and Locations

Study Contact

Kevin M Spencer, PhD
CONTACT
(774) 826-1375
Kevin.Spencer@va.gov

Principal Investigator

Kevin M. Spencer, PhD
PRINCIPAL_INVESTIGATOR
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

Study Locations (Sites)

VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, 02130-4817
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Kevin M. Spencer, PhD, PRINCIPAL_INVESTIGATOR, VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-12-02
Study Completion Date2027-07-29

Study Record Updates

Study Start Date2019-12-02
Study Completion Date2027-07-29

Terms related to this study

Keywords Provided by Researchers

  • mild traumatic brain injury
  • EEG
  • neuroplasticity
  • gamma oscillation

Additional Relevant MeSH Terms

  • mTBI