RECRUITING

Sleep-dependent Learning in Aging

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The specific objective of this proposed research is to understand whether deficits in sleep-dependent memory changes reflect age-related changes in sleep, memory, or both. The central hypothesis is that changes in both memory and sleep contribute to age-related changes in sleep-dependent memory processing. To this end, the investigators will investigate changes in learning following intervals of sleep (overnight and nap) and wake in young and older adults.

Official Title

What is Sleep's Role in Alzheimer's Disease? Insight From Healthy Aging

Quick Facts

Study Start:2018-07-15

Study Completion:2025-07-15

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT03840083

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Age 18-80 yrs * Healthy sleeper * No diagnosed sleep or neurodegenerative disorder	1. Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index \>15; a Period-Limb Movement in Sleep index of \>15/hr; sleep-onset latency \> 45 min (indicative of insomnia); or sleep efficiency \< 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation. 2. Past diagnosis neurological illness or head injury 3. Reported average sleep per night \< 5 or \> 9 hrs 4. Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing 5. Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants) 6. Daily caffeine intake of \> 4 cups (coffee, tea, colas) 7. Weekly alcohol intake of \> 10 cups 8. Pregnancy or \< 12 months post-partum 9. History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score \> 25 10. Abnormal sleep (e.g., shift work, travel across \>2 time zones within the past 3 months). 11. Diagnosis of any Axis I disorder, neurological illness or head injury (according to Demographic and Health History form); 12. Score indicative of cognitive dysfunction (subtest scores \< 40) 13. Beck Depression Scale score indicative of depression (\> 19). 1. Left handed or ambidextrous 2. Claustrophobia 3. Presence of metal (thoroughly screened via questionnaire and metal detector) 4. Pregnancy

Inclusion Criteria

Exclusion Criteria

* Age 18-80 yrs
* Healthy sleeper
* No diagnosed sleep or neurodegenerative disorder

1. Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index \>15; a Period-Limb Movement in Sleep index of \>15/hr; sleep-onset latency \> 45 min (indicative of insomnia); or sleep efficiency \< 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation.
2. Past diagnosis neurological illness or head injury
3. Reported average sleep per night \< 5 or \> 9 hrs
4. Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing
5. Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants)
6. Daily caffeine intake of \> 4 cups (coffee, tea, colas)
7. Weekly alcohol intake of \> 10 cups
8. Pregnancy or \< 12 months post-partum
9. History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score \> 25
10. Abnormal sleep (e.g., shift work, travel across \>2 time zones within the past 3 months).
11. Diagnosis of any Axis I disorder, neurological illness or head injury (according to Demographic and Health History form);
12. Score indicative of cognitive dysfunction (subtest scores \< 40)
13. Beck Depression Scale score indicative of depression (\> 19).
1. Left handed or ambidextrous
2. Claustrophobia
3. Presence of metal (thoroughly screened via questionnaire and metal detector)
4. Pregnancy

Contacts and Locations

Study Locations (Sites)

University of Massachusetts

Amherst, Massachusetts, 01003

United States

Collaborators and Investigators

Sponsor: University of Massachusetts, Amherst

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-07-15

Study Completion Date2025-07-15

Study Record Updates

Study Start Date2018-07-15

Study Completion Date2025-07-15

Terms related to this study

Additional Relevant MeSH Terms

Sleep