RECRUITING

Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is following up on previous studies that have demonstrated that geriatric subjects respond different to ultraviolet B (UVB) light than young subjects. The treatment of geriatric skin with dermal rejuvenation therapies (dermabrasion, fractionated laser resurfacing) restores the appropriate UVB response. Ongoing studies have tested the ability of fractionated laser resurfacing (FLR) to assess how long this wounding effect lasts-and have found that this appears to be a durable response which lasts for at least two years. The findings that FLR protects geriatric skin at two years is the impetus for this study. This study is an interventional study to assess if FLR treatment of one forearm of geriatric subjects with multiple actinic keratosis will result in the short-term removal of actinic keratosis, and the long-term decrease in levels of future actinic keratosis and other non-melanoma skin cancers in comparison to the untreated arm. Study length and visit: The first part of the study is completed in 1 day then there are follow up visits at 90 days and every 6 months for 5 years.

Official Title

Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia

Quick Facts

Study Start:2018-01-10
Study Completion:2028-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03906253

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosed with Actinic Keratosis within the past 6 months
  2. * At least 60 years of age, or older
  3. * Ability to comprehend procedures and risks versus benefits
  4. * Able to provide Informed Consent
  5. * Fair Skin (Fitzpatrick Type I or II)
  6. * Possess both Right and Left Forearms
  1. * Uncontrolled Diabetes Mellitus
  2. * Not able to comprehend procedures or risks versus benefits
  3. * Pregnant or nursing
  4. * Large tattoos on forearms
  5. * History of abnormal healing or scarring (i.e., keloids)
  6. * Any disease that gets worse while in the sun
  7. * Use of topical or oral anti-inflammatory medication or steroids
  8. * Allergy to lidocaine
  9. * Current use of photosensitizing medication

Contacts and Locations

Study Contact

Manager, Clinical Research Operations
CONTACT
937-245-7500
pturesearch@wrightstatephysicians.org
Regulatory Specialist
CONTACT
937-245-7500
pturesearch@wrightstatephysicians.org

Principal Investigator

Jeffrey B Travers, MD, PhD
PRINCIPAL_INVESTIGATOR
Wright State University

Study Locations (Sites)

Dayton VA Medical Center
Dayton, Ohio, 45428
United States

Collaborators and Investigators

Sponsor: Wright State University

  • Jeffrey B Travers, MD, PhD, PRINCIPAL_INVESTIGATOR, Wright State University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-01-10
Study Completion Date2028-12

Study Record Updates

Study Start Date2018-01-10
Study Completion Date2028-12

Terms related to this study

Additional Relevant MeSH Terms

  • Actinic Keratoses
  • Aging
  • Non-Melanoma Skin Cancer