RECRUITING

Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The Montalcino Aortic Consortium (MAC) will provide the infrastructure to assemble large cohorts of patients with mutations in known heritable thoracic aortic disease (H-TAD) genes, define the phenotype associated with these genes, and determine genetic and environmental modifiers of H-TAD.

Official Title

Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease

Quick Facts

Study Start:2016-04-29
Study Completion:2037-01-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04005976

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients and their relatives with a confirmed pathogenic, likely pathogenic variant, or variant of unknown clinical significance in at least one of the H-TAD genes (i.e. TGFBR1, TGFBR2, SMAD3, TGFB2, TGFB3, ACTA2, MYH11, MYLK, PRKG1, MAT2A, MFAP5, LOX, COL3A1, FOXE3, and FBN1).
  2. * Patients of all ages, sex and race for which informed consent can be obtained.
  1. * Patients without a confirmed causative variant for H-TAD.

Contacts and Locations

Study Contact

Study Director
CONTACT
713-500-6715
Program Manager
CONTACT
713-500-7386

Principal Investigator

Dianna Milewicz, MD, PhD
STUDY_DIRECTOR
UTHealth

Study Locations (Sites)

The University of Texas Health Science Center at Houston
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: The University of Texas Health Science Center, Houston

  • Dianna Milewicz, MD, PhD, STUDY_DIRECTOR, UTHealth

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2016-04-29
Study Completion Date2037-01-01

Study Record Updates

Study Start Date2016-04-29
Study Completion Date2037-01-01

Terms related to this study

Additional Relevant MeSH Terms

  • Aortic Aneurysm
  • Aortic Dissection
  • Aortic Diseases