RECRUITING

Ischemic Conditioning Improves Walking Function Post Stroke

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This innovative study will address scientific and clinical areas relatively unexplored in chronic stroke that could lead to greater recovery of walking. Ischemic Conditioning (IC) is a non-invasive, simple procedure that improves motor function, exercise performance and cardiovascular function in healthy controls, but it has never been applied to the stroke population. We postulate that IC enhances the recruitment of motoneurons and results in positive neural adaptations, improves vascular endothelial function and peripheral blood flow, and together these improvements result in an increased capacity to exercise and faster walking speed. Future studies will examine the effects of IC and traditional therapy at different time points of recovery post stroke, durability of IC, molecular mechanisms of neural and cardiovascular adaptation and the efficacy compared with other adjuncts.

Official Title

Ischemic Conditioning Improves Walking Function Post Stroke

Quick Facts

Study Start:2018-12-20
Study Completion:2025-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04038697

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Matthew J Durand, Ph.D.
CONTACT
4149555619
mdurand@mcw.edu
Allison S Hyngstrom, PT, Ph.D.
CONTACT
4142884566
allison.hyngstrom@marquette.edu

Study Locations (Sites)

Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
United States
Marquette University
Milwaukee, Wisconsin, 53233
United States

Collaborators and Investigators

Sponsor: Medical College of Wisconsin

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-12-20
Study Completion Date2025-06-30

Study Record Updates

Study Start Date2018-12-20
Study Completion Date2025-06-30

Terms related to this study

Keywords Provided by Researchers

  • Stroke
  • Rehabilitation
  • Ischemic Conditioning
  • Treadmill Training

Additional Relevant MeSH Terms

  • Stroke
  • Stroke, Ischemic
  • Stroke Hemorrhagic
  • Stroke, Cardiovascular