RECRUITING

Autoimmunity After Checkpoint Blockade

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to better understand how the treatment of cancer with immune checkpoint inhibitors (ICI) leads to the development of autoimmunity. Specifically, we wish to understand the genetics and immune system features that cause a subset of cancer patients treated with checkpoint inhibitor therapy to develop an immune-related adverse event (irAE).

Official Title

Mechanisms of Immunotoxicology in Cancer Patients

Quick Facts

Study Start:2020-02-24
Study Completion:2026-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04119713

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * A diagnosis of cancer and prescription for a checkpoint inhibitor
  1. * Any subjects not willing or able to give consent
  2. * Children under the age of 18
  3. * A history of transplant

Contacts and Locations

Study Contact

Kyra J Sacksith
CONTACT
215-898-9339
kyra.sacksith@pennmedicine.upenn.edu

Principal Investigator

Terri M Laufer, MD
PRINCIPAL_INVESTIGATOR
University of Pennsylvania

Study Locations (Sites)

University of Pennsylvania - Abramson Cancer Center
Philadelphia, Pennsylvania, 19104
United States

Collaborators and Investigators

Sponsor: University of Pennsylvania

  • Terri M Laufer, MD, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-02-24
Study Completion Date2026-06-30

Study Record Updates

Study Start Date2020-02-24
Study Completion Date2026-06-30

Terms related to this study

Additional Relevant MeSH Terms

  • Autoimmunity
  • Cancer
  • Immunotoxicity
  • Oncology