RECRUITING

S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer

Conditions

Extensive Stage Lung Small Cell Carcinoma Limited Stage Lung Small Cell Carcinoma Lung Small Cell Carcinoma

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. Monitoring with MRI scans alone (delaying radiation until the actual spread of the cancer) may be at least as good as the combination of PCI with MRI scans.

Official Title

MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)

Quick Facts

Study Start:2020-05-04

Study Completion:2027-11-15

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT04155034

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Patient must have a histologically confirmed diagnosis of small-cell lung cancer (SCLC) * Patient must have an MRI of the brain performed within 28 days prior to registration documenting no evidence of brain metastases or leptomeningeal disease. Patient also must not have a history of brain metastases or leptomeningeal disease * Immunotherapy concurrent with and/or adjuvant to first-line therapy is allowed at the discretion of the treating physician. Patients with limited-stage (LS)-SCLC must have completed platinum-based chemotherapy and either definitive thoracic radiotherapy (including stereotactic body radiation therapy \[SBRT\] for early-stage T1-2 N0 M0 disease who do not undergo surgery) or definitive surgical resection; thoracic radiation in addition to definitive surgical resection is allowed at the discretion of the treating physician, but is not required. Patients with extensive-stage (ES)-SCLC must have completed platinum-based chemotherapy either with or without thoracic radiotherapy at the discretion of the treating physician * All adverse events from prior treatment must have resolved to =\< grade 2 (Common Terminology Criteria for Adverse Events \[CTCAE\] version 5.0) prior to randomization * Patient must have had a response to first-line therapy and no evidence of progression in opinion of the treating investigator. Systemic imaging (computed tomography \[CT\] or positron emission tomography \[PET\]/CT including the chest and abdomen) must be performed within 28 days prior to randomization * No more than 8 weeks may have elapsed between day 1 of the last cycle of chemotherapy and randomization * Patient must not have received prior radiotherapy to the brain or whole brain radiotherapy. Patients who have undergone prior stereotactic radiosurgery for benign tumors or conditions (e.g., acoustic neuroma, grade I meningioma, trigeminal neuralgia) may be considered on a case-by-case basis * Patient must have Zubrod performance status of 0-2 * Patient must not have a contraindication to MR imaging, such as implanted metal devices or foreign bodies * Patient must not have a contraindication to gadolinium contrast administration during MR imaging, such as allergy or insufficient renal function * Patient must not have other metastatic malignancies requiring current active treatment * Patient must not have any severe active comorbidities, defined as follows: * Unstable angina and/or congestive heart failure requiring hospitalization within 6 months prior to randomization * Transmural myocardial infarction within 6 months prior to randomization * Acute bacterial or fungal infection requiring intravenous antibiotics at the time of randomization * Chronic obstructive pulmonary disease exacerbation or other acute respiratory illness precluding study therapy at the time of randomization * Severe hepatic disease defined as a diagnosis of Child-Pugh class B or C hepatic disease * Human immunodeficiency virus (HIV) positive with CD4 count \< 200 cells/microliter * Note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count \>= 200 cells/microliter within 16 weeks prior to randomization * Note also that HIV testing is not required for eligibility for this protocol * Patient must not be pregnant because of fetal risks from radiation exposure. Men must have agreed to use an effective contraceptive method during PCI and for six months after completing PCI. Women of reproductive potential must have agreed to use an effective contraceptive method during PCI. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures * Patients who speak and understand English or French must agree to participate in cognitive function testing * Patient must be offered the opportunity to have specimens submitted for banking * Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines * As a part of the Oncology Patient Enrollment Network (OPEN) randomization process the treating institution?s identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system	Pregnancy or breastfeeding Severe psychiatric disorders Active substance abuse Unstable medical conditions Inability to comply with study requirements

Inclusion Criteria

Exclusion Criteria

* Patient must have a histologically confirmed diagnosis of small-cell lung cancer (SCLC)
* Patient must have an MRI of the brain performed within 28 days prior to registration documenting no evidence of brain metastases or leptomeningeal disease. Patient also must not have a history of brain metastases or leptomeningeal disease
* Immunotherapy concurrent with and/or adjuvant to first-line therapy is allowed at the discretion of the treating physician. Patients with limited-stage (LS)-SCLC must have completed platinum-based chemotherapy and either definitive thoracic radiotherapy (including stereotactic body radiation therapy \[SBRT\] for early-stage T1-2 N0 M0 disease who do not undergo surgery) or definitive surgical resection; thoracic radiation in addition to definitive surgical resection is allowed at the discretion of the treating physician, but is not required. Patients with extensive-stage (ES)-SCLC must have completed platinum-based chemotherapy either with or without thoracic radiotherapy at the discretion of the treating physician
* All adverse events from prior treatment must have resolved to =\< grade 2 (Common Terminology Criteria for Adverse Events \[CTCAE\] version 5.0) prior to randomization
* Patient must have had a response to first-line therapy and no evidence of progression in opinion of the treating investigator. Systemic imaging (computed tomography \[CT\] or positron emission tomography \[PET\]/CT including the chest and abdomen) must be performed within 28 days prior to randomization
* No more than 8 weeks may have elapsed between day 1 of the last cycle of chemotherapy and randomization
* Patient must not have received prior radiotherapy to the brain or whole brain radiotherapy. Patients who have undergone prior stereotactic radiosurgery for benign tumors or conditions (e.g., acoustic neuroma, grade I meningioma, trigeminal neuralgia) may be considered on a case-by-case basis
* Patient must have Zubrod performance status of 0-2
* Patient must not have a contraindication to MR imaging, such as implanted metal devices or foreign bodies
* Patient must not have a contraindication to gadolinium contrast administration during MR imaging, such as allergy or insufficient renal function
* Patient must not have other metastatic malignancies requiring current active treatment
* Patient must not have any severe active comorbidities, defined as follows:
* Unstable angina and/or congestive heart failure requiring hospitalization within 6 months prior to randomization
* Transmural myocardial infarction within 6 months prior to randomization
* Acute bacterial or fungal infection requiring intravenous antibiotics at the time of randomization
* Chronic obstructive pulmonary disease exacerbation or other acute respiratory illness precluding study therapy at the time of randomization
* Severe hepatic disease defined as a diagnosis of Child-Pugh class B or C hepatic disease
* Human immunodeficiency virus (HIV) positive with CD4 count \< 200 cells/microliter
* Note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count \>= 200 cells/microliter within 16 weeks prior to randomization
* Note also that HIV testing is not required for eligibility for this protocol
* Patient must not be pregnant because of fetal risks from radiation exposure. Men must have agreed to use an effective contraceptive method during PCI and for six months after completing PCI. Women of reproductive potential must have agreed to use an effective contraceptive method during PCI. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
* Patients who speak and understand English or French must agree to participate in cognitive function testing
* Patient must be offered the opportunity to have specimens submitted for banking
* Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
* As a part of the Oncology Patient Enrollment Network (OPEN) randomization process the treating institution?s identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

Pregnancy or breastfeeding
Severe psychiatric disorders
Active substance abuse
Unstable medical conditions
Inability to comply with study requirements

Contacts and Locations

Principal Investigator

Chad G Rusthoven

PRINCIPAL_INVESTIGATOR

SWOG Cancer Research Network

Study Locations (Sites)

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233

United States

University of Arizona Cancer Center-Orange Grove Campus

Tucson, Arizona, 85704

United States

University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719

United States

City of Hope Comprehensive Cancer Center

Duarte, California, 91010

United States

Veterans Affairs Loma Linda Healthcare System

Loma Linda, California, 92357

United States

Tibor Rubin VA Medical Center

Long Beach, California, 90822

United States

Los Angeles County-USC Medical Center

Los Angeles, California, 90033

United States

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033

United States

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817

United States

Veterans Affairs Medical Center - San Francisco

San Francisco, California, 94121

United States

City of Hope South Pasadena

South Pasadena, California, 91030

United States

Rocky Mountain Regional VA Medical Center

Aurora, Colorado, 80045

United States

University of Colorado Hospital

Aurora, Colorado, 80045

United States

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909

United States

Memorial Hospital North

Colorado Springs, Colorado, 80920

United States

Poudre Valley Hospital

Fort Collins, Colorado, 80524

United States

Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, 80528

United States

North Colorado Medical Center

Greeley, Colorado, 80631

United States

UCHealth Greeley Hospital

Greeley, Colorado, 80631

United States

UCHealth Highlands Ranch Hospital

Highlands Ranch, Colorado, 80129

United States

Medical Center of the Rockies

Loveland, Colorado, 80538

United States

McKee Medical Center

Loveland, Colorado, 80539

United States

Smilow Cancer Hospital Care Center at Greenwich

Greenwich, Connecticut, 06830

United States

Smilow Cancer Hospital Care Center - Guiford

Guilford, Connecticut, 06437

United States

Smilow Cancer Hospital-Hamden Care Center

Hamden, Connecticut, 06518

United States

Yale University

New Haven, Connecticut, 06520

United States

Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611

United States

Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385

United States

Veterans Affairs Connecticut Healthcare System-West Haven Campus

West Haven, Connecticut, 06516

United States

Beebe South Coastal Health Campus

Frankford, Delaware, 19945

United States

Helen F Graham Cancer Center

Newark, Delaware, 19713

United States

Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713

United States

Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718

United States

Beebe Health Campus

Rehoboth Beach, Delaware, 19971

United States

John Fitzgerald Kennedy Medical Center

Atlantis, Florida, 33462

United States

Boca Raton Regional Hospital

Boca Raton, Florida, 33486

United States

Morton Plant Hospital

Clearwater, Florida, 33756

United States

UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146

United States

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442

United States

University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610

United States

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136

United States

Moffitt Cancer Center

Tampa, Florida, 33612

United States

Northside Hospital-Alpharetta

Alpharetta, Georgia, 30005

United States

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322

United States

Northside Hospital

Atlanta, Georgia, 30342

United States

Augusta University Medical Center

Augusta, Georgia, 30912

United States

Northside Hospital-Cherokee

Canton, Georgia, 30115

United States

John B Amos Cancer Center

Columbus, Georgia, 31904

United States

Northside Hospital-Forsyth

Cumming, Georgia, 30041

United States

Atlanta VA Medical Center

Decatur, Georgia, 30033

United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405

United States

Hawaii Cancer Care - Savio

'Aiea, Hawaii, 96701

United States

Pali Momi Medical Center

'Aiea, Hawaii, 96701

United States

The Cancer Center of Hawaii-Pali Momi

'Aiea, Hawaii, 96701

United States

Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813

United States

Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813

United States

Queen's Medical Center

Honolulu, Hawaii, 96813

United States

Straub Clinic and Hospital

Honolulu, Hawaii, 96813

United States

Kuakini Medical Center

Honolulu, Hawaii, 96817

United States

Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817

United States

The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817

United States

Alton Memorial Hospital

Alton, Illinois, 62002

United States

Northwestern University

Chicago, Illinois, 60611

United States

Rush University Medical Center

Chicago, Illinois, 60612

United States

University of Illinois

Chicago, Illinois, 60612

United States

Carle on Vermilion

Danville, Illinois, 61832

United States

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526

United States

Decatur Memorial Hospital

Decatur, Illinois, 62526

United States

Carle Physician Group-Effingham

Effingham, Illinois, 62401

United States

Edward Hines Jr VA Hospital

Hines, Illinois, 60141

United States

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938

United States

Loyola University Medical Center

Maywood, Illinois, 60153

United States

Methodist Medical Center of Illinois

Peoria, Illinois, 61636

United States

OSF Saint Francis Medical Center

Peoria, Illinois, 61637

United States

Memorial Hospital East

Shiloh, Illinois, 62269

United States

Southern Illinois University School of Medicine

Springfield, Illinois, 62702

United States

Springfield Clinic

Springfield, Illinois, 62702

United States

Memorial Medical Center

Springfield, Illinois, 62781

United States

Carle Cancer Center

Urbana, Illinois, 61801

United States

Northwest Cancer Center - Main Campus

Crown Point, Indiana, 46307

United States

Northwest Oncology LLC

Dyer, Indiana, 46311

United States

Northwest Cancer Center - Hobart

Hobart, Indiana, 46342

United States

Saint Mary Medical Center

Hobart, Indiana, 46342

United States

The Community Hospital

Munster, Indiana, 46321

United States

Women's Diagnostic Center - Munster

Munster, Indiana, 46321

United States

Northwest Cancer Center - Valparaiso

Valparaiso, Indiana, 46383

United States

McFarland Clinic PC - Ames

Ames, Iowa, 50010

United States

Mercy Hospital

Cedar Rapids, Iowa, 52403

United States

Oncology Associates at Mercy Medical Center

Cedar Rapids, Iowa, 52403

United States

Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, 50325

United States

Mercy Cancer Center-West Lakes

Clive, Iowa, 50325

United States

Greater Regional Medical Center

Creston, Iowa, 50801

United States

Iowa Methodist Medical Center

Des Moines, Iowa, 50309

United States

Medical Oncology and Hematology Associates-Des Moines

Des Moines, Iowa, 50309

United States

Broadlawns Medical Center

Des Moines, Iowa, 50314

United States

Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314

United States

Mission Cancer and Blood - Laurel

Des Moines, Iowa, 50314

United States

Iowa Lutheran Hospital

Des Moines, Iowa, 50316

United States

Methodist West Hospital

West Des Moines, Iowa, 50266-7700

United States

Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266

United States

University of Kansas Cancer Center

Kansas City, Kansas, 66160

United States

Lawrence Memorial Hospital

Lawrence, Kansas, 66044

United States

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210

United States

University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606

United States

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205

United States

Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214

United States

Wesley Medical Center

Wichita, Kansas, 67214

United States

Saint Elizabeth Healthcare Edgewood

Edgewood, Kentucky, 41017

United States

Saint Elizabeth Fort Thomas

Fort Thomas, Kentucky, 41075

United States

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536

United States

The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202

United States

East Jefferson General Hospital

Metairie, Louisiana, 70006

United States

Louisiana State University Health Science Center

New Orleans, Louisiana, 70112

United States

University Medical Center New Orleans

New Orleans, Louisiana, 70112

United States

MaineHealth Coastal Cancer Treatment Center

Bath, Maine, 04530

United States

Lafayette Family Cancer Center-EMMC

Brewer, Maine, 04412

United States

Maine Medical Center-Bramhall Campus

Portland, Maine, 04102

United States

MaineHealth Cancer Care Center of York County

Sanford, Maine, 04073

United States

Maine Medical Center- Scarborough Campus

Scarborough, Maine, 04074

United States

Anne Arundel Medical Center

Annapolis, Maryland, 21401

United States

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201

United States

Veterans Administration Medical Center-Baltimore

Baltimore, Maryland, 21201

United States

UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014

United States

Central Maryland Radiation Oncology in Howard County

Columbia, Maryland, 21044

United States

University of Maryland Shore Medical Center at Easton

Easton, Maryland, 21601

United States

UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061

United States

TidalHealth Richard A Henson Cancer Institute

Ocean Pines, Maryland, 21811

United States

TidalHealth Peninsula Regional

Salisbury, Maryland, 21801

United States

Brigham and Women's Hospital

Boston, Massachusetts, 02115

United States

Boston Medical Center

Boston, Massachusetts, 02118

United States

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215

United States

Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805

United States

Dana-Farber/Brigham and Women's Cancer Center at Milford Regional

Milford, Massachusetts, 01757

United States

Beth Israel Deaconess Hospital-Plymouth

Plymouth, Massachusetts, 02360

United States

Dana-Farber/Brigham and Women's Cancer Center at South Shore

South Weymouth, Massachusetts, 02190

United States

Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106

United States

Saint Joseph Mercy Brighton

Brighton, Michigan, 48114

United States

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114

United States

Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183

United States

Saint Joseph Mercy Canton

Canton, Michigan, 48188

United States

Saint Joseph Mercy Chelsea

Chelsea, Michigan, 48118

United States

Beaumont Hospital - Dearborn

Dearborn, Michigan, 48124

United States

Henry Ford Hospital

Detroit, Michigan, 48202

United States

Ascension Saint John Hospital

Detroit, Michigan, 48236

United States

West Michigan Cancer Center

Kalamazoo, Michigan, 49007

United States

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154

United States

21st Century Oncology-Pontiac

Pontiac, Michigan, 48341

United States

Saint Joseph Mercy Oakland

Pontiac, Michigan, 48341

United States

William Beaumont Hospital-Royal Oak

Royal Oak, Michigan, 48073

United States

Ascension Saint Mary's Hospital

Saginaw, Michigan, 48601

United States

Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604

United States

Ascension Saint Joseph Hospital

Tawas City, Michigan, 48764

United States

Munson Medical Center

Traverse City, Michigan, 49684

United States

William Beaumont Hospital - Troy

Troy, Michigan, 48085

United States

Saint John Macomb-Oakland Hospital

Warren, Michigan, 48093

United States

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322

United States

Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661

United States

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197

United States

Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601

United States

Miller-Dwan Hospital

Duluth, Minnesota, 55805

United States

Hennepin County Medical Center

Minneapolis, Minnesota, 55415

United States

Baptist Memorial Hospital and Cancer Center-Oxford

Oxford, Mississippi, 38655

United States

Baptist Memorial Hospital and Cancer Center-Desoto

Southhaven, Mississippi, 38671

United States

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703

United States

University of Missouri - Ellis Fischel

Columbia, Missouri, 65212

United States

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141

United States

Parkland Health Center - Farmington

Farmington, Missouri, 63640

United States

Freeman Health System

Joplin, Missouri, 64804

United States

University of Kansas Cancer Center - North

Kansas City, Missouri, 64154

United States

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064

United States

University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116

United States

Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, 65401

United States

Washington University School of Medicine

Saint Louis, Missouri, 63110

United States

Siteman Cancer Center-South County

Saint Louis, Missouri, 63129

United States

Missouri Baptist Medical Center

Saint Louis, Missouri, 63131

United States

Siteman Cancer Center at Christian Hospital

Saint Louis, Missouri, 63136

United States

Siteman Cancer Center at Saint Peters Hospital

Saint Peters, Missouri, 63376

United States

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670

United States

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080

United States

Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, 59701

United States

Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, 59405

United States

Kalispell Regional Medical Center

Kalispell, Montana, 59901

United States

Nebraska Methodist Hospital

Omaha, Nebraska, 68114

United States

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124

United States

Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus

Elizabeth, New Jersey, 07207

United States

The Cancer Institute of New Jersey Hamilton

Hamilton, New Jersey, 08690

United States

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903

United States

Capital Health Medical Center-Hopewell

Pennington, New Jersey, 08534

United States

Chilton Medical Center

Pompton, New Jersey, 07444

United States

Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, 08876

United States

Overlook Hospital

Summit, New Jersey, 07902

United States

Community Medical Center

Toms River, New Jersey, 08755

United States

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87102

United States

Lovelace Radiation Oncology

Albuquerque, New Mexico, 87109

United States

Montefiore Medical Center-Einstein Campus

Bronx, New York, 10461

United States

Montefiore Medical Center-Weiler Hospital

Bronx, New York, 10461

United States

Montefiore Medical Center - Moses Campus

Bronx, New York, 10467

United States

Roswell Park Cancer Institute

Buffalo, New York, 14263

United States

Sands Cancer Center

Canandaigua, New York, 14424

United States

Glens Falls Hospital

Glens Falls, New York, 12801

United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032

United States

Highland Hospital

Rochester, New York, 14620

United States

University of Rochester

Rochester, New York, 14642

United States

Stony Brook University Medical Center

Stony Brook, New York, 11794

United States

State University of New York Upstate Medical University

Syracuse, New York, 13210

United States

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203

United States

Durham VA Medical Center

Durham, North Carolina, 27705

United States

CaroMont Regional Medical Center

Gastonia, North Carolina, 28054

United States

CarolinaEast Medical Center

New Bern, North Carolina, 28561

United States

Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501

United States

Sanford Broadway Medical Center

Fargo, North Dakota, 58122

United States

Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122

United States

Altru Cancer Center

Grand Forks, North Dakota, 58201

United States

Cleveland Clinic Akron General

Akron, Ohio, 44307

United States

UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, 44122

United States

Cleveland Clinic Mercy Hospital

Canton, Ohio, 44708

United States

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219

United States

Case Western Reserve University

Cleveland, Ohio, 44106

United States

Louis Stokes Cleveland VA Medical Center

Cleveland, Ohio, 44106

United States

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

United States

Riverside Methodist Hospital

Columbus, Ohio, 43214

United States

Dublin Methodist Hospital

Dublin, Ohio, 43016

United States

Mount Carmel Grove City Hospital

Grove City, Ohio, 43123

United States

UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060

United States

UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, 44130

United States

University Hospitals Parma Medical Center

Parma, Ohio, 44129

United States

Mercy Health Perrysburg Cancer Center

Perrysburg, Ohio, 43551

United States

University Hospitals Portage Medical Center

Ravenna, Ohio, 44266

United States

Mercy Health - Saint Anne Hospital

Toledo, Ohio, 43623

United States

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069

United States

UH Seidman Cancer Center at Saint John Medical Center

Westlake, Ohio, 44145

United States

UHHS-Westlake Medical Center

Westlake, Ohio, 44145

United States

Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701

United States

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

United States

UPMC-Heritage Valley Health System Beaver

Beaver, Pennsylvania, 15009

United States

Crozer-Keystone Regional Cancer Center at Broomall

Broomall, Pennsylvania, 19008

United States

Carlisle Regional Cancer Center

Carlisle, Pennsylvania, 17015

United States

Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317

United States

Geisinger Medical Center

Danville, Pennsylvania, 17822

United States

Fox Chase Cancer Center - East Norriton Hospital Outpatient Center

East Norriton, Pennsylvania, 19401

United States

Ephrata Cancer Center

Ephrata, Pennsylvania, 17522

United States

UPMC Hillman Cancer Center Erie

Erie, Pennsylvania, 16505

United States

UPMC Cancer Center at UPMC Horizon

Farrell, Pennsylvania, 16121

United States

Fox Chase Cancer Center Buckingham

Furlong, Pennsylvania, 18925

United States

Adams Cancer Center

Gettysburg, Pennsylvania, 17325

United States

Crozer Regional Cancer Center at Brinton Lake

Glen Mills, Pennsylvania, 19342

United States

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, 15601

United States

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109

United States

UPMC-Johnstown/John P. Murtha Regional Cancer Center

Johnstown, Pennsylvania, 15901

United States

Sechler Family Cancer Center

Lebanon, Pennsylvania, 17042

United States

Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837

United States

UPMC Cancer Center at UPMC McKeesport

McKeesport, Pennsylvania, 15132

United States

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

Mechanicsburg, Pennsylvania, 17050

United States

UPMC Cancer Center - Monroeville

Monroeville, Pennsylvania, 15146

United States

UPMC Hillman Cancer Center in Coraopolis

Moon, Pennsylvania, 15108

United States

Paoli Memorial Hospital

Paoli, Pennsylvania, 19301

United States

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111

United States

Temple University Hospital

Philadelphia, Pennsylvania, 19140

United States

UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, 15213

United States

UPMC-Saint Margaret

Pittsburgh, Pennsylvania, 15215

United States

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232

United States

UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232

United States

UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, 15237

United States

UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, Pennsylvania, 15243

United States

Guthrie Medical Group PC-Robert Packer Hospital

Sayre, Pennsylvania, 18840

United States

UPMC Cancer Center at UPMC Northwest

Seneca, Pennsylvania, 16346

United States

UPMC Uniontown Hospital Radiation Oncology

Uniontown, Pennsylvania, 15401

United States

UPMC Washington Hospital Radiation Oncology

Washington, Pennsylvania, 15301

United States

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711

United States

UPMC Susquehanna

Williamsport, Pennsylvania, 17701

United States

Lankenau Medical Center

Wynnewood, Pennsylvania, 19096

United States

WellSpan Health-York Cancer Center

York, Pennsylvania, 17403

United States

UPMC Memorial

York, Pennsylvania, 17408

United States

Saint Joseph's/Candler - Bluffton Campus

Bluffton, South Carolina, 29910

United States

Saint Francis Hospital

Greenville, South Carolina, 29601

United States

Saint Francis Cancer Center

Greenville, South Carolina, 29607

United States

Self Regional Healthcare

Greenwood, South Carolina, 29646

United States

Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651

United States

Spartanburg Medical Center

Spartanburg, South Carolina, 29303

United States

Avera Cancer Institute at Pierre

Pierre, South Dakota, 57501

United States

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104

United States

Avera Cancer Institute

Sioux Falls, South Dakota, 57105

United States

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134

United States

Avera Cancer Institute at Yankton

Yankton, South Dakota, 57078

United States

Baptist Memorial Hospital and Cancer Center-Collierville

Collierville, Tennessee, 38017

United States

Baptist Memorial Hospital and Cancer Center-Memphis

Memphis, Tennessee, 38120

United States

MD Anderson in The Woodlands

Conroe, Texas, 77384

United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030

United States

Ben Taub General Hospital

Houston, Texas, 77030

United States

M D Anderson Cancer Center

Houston, Texas, 77030

United States

Michael E DeBakey VA Medical Center

Houston, Texas, 77030

United States

MD Anderson West Houston

Houston, Texas, 77079

United States

MD Anderson League City

League City, Texas, 77573

United States

Audie L Murphy VA Hospital

San Antonio, Texas, 78229

United States

MD Anderson in Sugar Land

Sugar Land, Texas, 77478

United States

Farmington Health Center

Farmington, Utah, 84025

United States

University of Utah Sugarhouse Health Center

Salt Lake City, Utah, 84106

United States

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112

United States

Augusta Health Center for Cancer and Blood Disorders

Fishersville, Virginia, 22939

United States

VCU Massey Cancer Center at Stony Point

Richmond, Virginia, 23235

United States

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

United States

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409

United States

ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911

United States

Northwest Wisconsin Cancer Center

Ashland, Wisconsin, 54806

United States

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701

United States

Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311

United States

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601

United States

Marshfield Clinic - Ladysmith Center

Ladysmith, Wisconsin, 54848

United States

Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143

United States

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449

United States

Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051

United States

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215

United States

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

United States

Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233

United States

Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, 53295

United States

Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, 54548

United States

ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149

United States

Drexel Town Square Health Center

Oak Creek, Wisconsin, 53154

United States

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066

United States

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868

United States

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482

United States

UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188

United States

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401

United States

Aurora West Allis Medical Center

West Allis, Wisconsin, 53227

United States

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095

United States

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476

United States

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494

United States

Collaborators and Investigators

Sponsor: SWOG Cancer Research Network

Chad G Rusthoven, PRINCIPAL_INVESTIGATOR, SWOG Cancer Research Network

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-05-04

Study Completion Date2027-11-15

Study Record Updates

Study Start Date2020-05-04

Study Completion Date2027-11-15

Terms related to this study

Additional Relevant MeSH Terms

Extensive Stage Lung Small Cell Carcinoma
Limited Stage Lung Small Cell Carcinoma
Lung Small Cell Carcinoma