RECRUITING

Th-1 Dendritic Cell Immunotherapy Plus Standard Chemotherapy for Pancreatic Adenocarcinoma

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a phase 1, first in human, dose escalation study for safety and feasibility of multi-dose dendritic cell (DC) therapy for pancreatic ductal adenocarcinoma (PDAC) including adenosquamous carcinoma administered after surgical resection of PDAC.

Official Title

Phase I Study of Th-1 Dendritic Cell Immunotherapy in Combination With Standard Chemotherapy for the Adjuvant Treatment of Pancreatic Adenocarcinoma (DECIST)

Quick Facts

Study Start:2020-08-03
Study Completion:2027-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04157127

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Benjamin Musher, MD
CONTACT
713-798-4292
blmusher@bcm.edu

Principal Investigator

Benjamin Musher, MD
PRINCIPAL_INVESTIGATOR
Baylor College of Medicine

Study Locations (Sites)

Baylor College of Medicine Medical Center - McNair Campus
Houston, Texas, 77030
United States
Baylor St. Lukes Medical Center
Houston, Texas, 77030
United States
Dan L. Duncan Cancer Center at Baylor College of Medicine
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: Diakonos Oncology Corporation

  • Benjamin Musher, MD, PRINCIPAL_INVESTIGATOR, Baylor College of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-08-03
Study Completion Date2027-12

Study Record Updates

Study Start Date2020-08-03
Study Completion Date2027-12

Terms related to this study

Keywords Provided by Researchers

  • Immunotherapy
  • Adjuvant therapy
  • Cell Therapy

Additional Relevant MeSH Terms

  • Pancreatic Adenocarcinoma
  • Pancreatic Cancer
  • Pancreatic Adenosquamous Carcinoma