RECRUITING

The Efficacy of Tranexamic Acid in the Treatment of Lichen Planus Pigmentosus and Erythema Dyschromicum Perstans

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

There are currently no effective treatments for lichen planus pigmentosus (LPP) and erythema dyschromicum perstans (EDP). Tranexamic acid, which may downregulate pigmentation through a reduction in plasmin, has been shown to decrease pigmentation in patients with melasma, another pigmentary disorder. Given that LPP, EDP, and melasma are all disorders of pigmentation with dermal involvement, it is possible that tranexamic acid can also reduce pigmentation in LPP and EDP as well.

Official Title

The Efficacy of Tranexamic Acid in the Treatment of Lichen Planus Pigmentosus and Erythema Dyschromicum Perstans

Quick Facts

Study Start:2020-03-17
Study Completion:2024-12-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04233749

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Subject age 18 and older
  2. * Subject with a diagnosis of LPP, EDP, or AD
  3. * Subject able to understand requirements of the study and risks involved
  4. * Subject able to sign a consent form
  5. * Subject to have discontinued all topical or oral medications, with the exception of sunscreen, used to treat pigmentary abnormalities one month prior to treatment
  1. * Personal history of clotting disorder or thromboembolic disease (deep vein thrombosis (DVT), stroke, etc)
  2. * Active malignancy, excluding non-melanoma skin cancer
  3. * Moderate to severe renal impairment
  4. * History of migraine with aura
  5. * Current anticoagulant therapy
  6. * Current use of hormonal contraception or hormone replacement therapy in the last 30 days
  7. * A woman who is lactating, pregnant, or planning to become pregnant

Contacts and Locations

Study Contact

Angela Parks-Miller, CCRP, CWCA
CONTACT
1-313-916-0426
amiller5@hfhs.org
Shanthi Narla, MD
CONTACT
1-313-916-0412
snarla1@hfhs.org

Principal Investigator

Henry W Lim, MD
PRINCIPAL_INVESTIGATOR
Henry Ford HS

Study Locations (Sites)

New Center One
Detroit, Michigan, 48202
United States

Collaborators and Investigators

Sponsor: Henry Ford Health System

  • Henry W Lim, MD, PRINCIPAL_INVESTIGATOR, Henry Ford HS

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-03-17
Study Completion Date2024-12-30

Study Record Updates

Study Start Date2020-03-17
Study Completion Date2024-12-30

Terms related to this study

Additional Relevant MeSH Terms

  • Lichen Planus Pigmentosus
  • Erythema Dyschromicum Perstans
  • Ashy Dermatosis of Ramirez