RECRUITING

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Description

PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.

Conditions

Cognitive Impairment, MildDementiaCardiovascular Diseases
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Related Conditions:

Cognitive Impairment, MildDementiaCardiovascular Diseases

Study Overview

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Study Details

Study overview

PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.

PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Condition
Cognitive Impairment, Mild
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35205

Birmingham

Birmingham VA, Birmingham, Alabama, United States, 35233

Tucson

Southern Arizona VA Health Care System - Tucson, Tucson, Arizona, United States, 85723

Little Rock

Little Rock VA Medical Center, Little Rock, Arkansas, United States, 72114

Little Rock

University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States, 72204

Fresno

Fresno VA Medical Center, Fresno, California, United States, 93703

Long Beach

Long Beach VA Medical Center, Long Beach, California, United States, 90822

Los Angeles

Cedars-Sinai Medical Center, Los Angeles, California, United States, 90048

Los Angeles

VA Greater Los Angeles, Los Angeles, California, United States, 90073

Palo Alto

VA Palo Alto Healthcare System, Palo Alto, California, United States, 94550

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Community-dwelling adults
  • * Age ≥75 years
  • * English or Spanish as primary language
  • * Able to provide a trusted contact
  • * Clinically evident cardiovascular disease defined as prior myocardial Infarction (MI), prior stroke, prior revascularization procedure, or a secondary prevention indication for a statin (clinician determined)
  • * Hospitalization for a primary diagnosis of heart failure in the prior 12 months (Note: History of heart failure in the absence of recent hospitalization or clinically evident cardiovascular disease is not an exclusion)
  • * Dementia (clinically evident or previously diagnosed)
  • * Dependence in any Katz Basic Activities of Daily Living \[ADL\] (with the exception of urinary or bowel continence)
  • * Severe hearing impairment (preventing phone follow up)
  • * Unable to talk (preventing phone follow up)
  • * Statin use in the past year or for longer than 5 years previously (participant reported)
  • * Ineligible to take atorvastatin 40 mg (clinician determined)
  • * Documented intolerance to statins
  • * Active Liver Disease

Ages Eligible for Study

75 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Duke University,

Study Record Dates

2026-12-31