ACTIVE_NOT_RECRUITING

Ovarian Function Following Intraovarian Injection of PRP

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Consenting women with evidence of poor ovarian reserve will be randomly assigned to treatment with either Platelet Rich Plasma (PRP) or Platelet Poor Plasma (PPP).

Official Title

Randomized Controlled Trial of Ovarian Function Following Intraovarian Injection of Platelet Rich Plasma for Women With Ovarian Aging

Quick Facts

Study Start:2020-02-24
Study Completion:2026-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04278313

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 44 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * fewer than 6 oocytes in response to past ovulation induction
  2. * desire to establish a pregnancy using IVF
  3. * Age 44 years and under.
  4. * FSH \> 12
  5. * AMH \< 1.0
  6. * No Aspirin or Motrin for one week before treatment
  1. * Age \> 45 years
  2. * Marked thrombocytopenia
  3. * Blood diseases
  4. * Hypofibrinogenemia
  5. * Hemodynamic instability
  6. * Anticoagulant or antiaggregant treatment
  7. * Oncological diseases (specially, skeletal system and blood)
  8. * Sepsis
  9. * Acute and chronic infectious diseases
  10. * Autoimmune diseases, for example, lupus erythematosus, etc.

Contacts and Locations

Principal Investigator

David H Barad, MD
PRINCIPAL_INVESTIGATOR
Center for Human Reproduction

Study Locations (Sites)

Center for Human Reproduction
New York, New York, 10021
United States

Collaborators and Investigators

Sponsor: Center for Human Reproduction

  • David H Barad, MD, PRINCIPAL_INVESTIGATOR, Center for Human Reproduction

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-02-24
Study Completion Date2026-12-31

Study Record Updates

Study Start Date2020-02-24
Study Completion Date2026-12-31

Terms related to this study

Keywords Provided by Researchers

  • Infertility - Ovarian dysfunuction
  • Diminished Ovarian Reserve
  • Premature Ovarian Aging (POA)

Additional Relevant MeSH Terms

  • Diminished Ovarian Reserve
  • Diminished Ovarian Reserve Due to Advanced Maternal Age