RECRUITING

Brain Connections for Arm Movement After Stroke

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Conditions

StrokeBrain DiseaseCentral Nervous System DiseasesNervous System DiseasesCardiovascular Diseases

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after stroke and when these brain areas are most sensitive to TMS.

Official Title

Brain Areas That Control Reaching Movements After Stroke: Task-relevant Connectivity and Movement-synchronized Brain Stimulation

Quick Facts

Study Start:2020-01-10
Study Completion:2026-06-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04286516

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:45 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Be 45-90 years of age
  2. * Have adequate language and neurocognitive function to participate in training and testing
  3. * Be medically stable to participate in the study
  4. * Be English speaking
  5. * Be 45-90 years of age
  6. * Clinically defined, unilateral, hemiparetic stroke with radiologic exclusion of other possible diagnosis
  7. * Stroke onset at least 6 months before enrollment
  8. * Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe)
  9. * Present with mild to moderate arm dysfunction
  10. * Be medically stable to participate in the study
  11. * Be English speaking
  1. * Unable to give informed consent
  2. * Have a serious complicating medical illness that would preclude participation
  3. * Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities
  4. * Visual loss such that the subject would not be able to see the test patterns on the robot computer monitor
  5. * Unable to comply with requirements of the study
  6. * Enrollment in another greater-than-minimal risk study
  7. * Presence of medical condition or implant that prevents safe administration of TMS or MRI
  8. * Pregnancy

Contacts and Locations

Study Contact

Amy Boos
CONTACT
(412) 648-4179
amy.boos2@va.gov
George F Wittenberg, MD PhD
CONTACT
(412) 360-6185
George.Wittenberg@va.gov

Principal Investigator

George F. Wittenberg, MD PhD
PRINCIPAL_INVESTIGATOR
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

Study Locations (Sites)

VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
Pittsburgh, Pennsylvania, 15240
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • George F. Wittenberg, MD PhD, PRINCIPAL_INVESTIGATOR, VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-01-10
Study Completion Date2026-06-01

Study Record Updates

Study Start Date2020-01-10
Study Completion Date2026-06-01

Terms related to this study

Additional Relevant MeSH Terms

  • Stroke
  • Brain Disease
  • Central Nervous System Diseases
  • Nervous System Diseases
  • Cardiovascular Diseases