ACTIVE_NOT_RECRUITING

Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This exploratory study investigates how an imaging technique called 68Ga-FAPi-46 PET/CT can determine where and to which degree the FAPI tracer (68Ga-FAPi-46) accumulates in normal and cancer tissues in patients with cancer. Because some cancers take up 68Ga-FAPi-46 it can be seen with PET. FAP stands for Fibroblast Activation Protein. FAP is produced by cells that surround tumors (cancer associated fibroblasts). The function of FAP is not well understood but imaging studies have shown that FAP can be detected with FAPI PET/CT. Imaging FAP with FAPI PET/CT may in the future provide additional information about various cancers.

Official Title

PET Biodistribution Study of 68Ga-FAPI-46 in Patients With Different Malignancies: An Exploratory Biodistribution Study With Histopathology Validation

Quick Facts

Study Start:2020-08-27
Study Completion:2027-07-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04459273

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients with the following cancer types:
  2. * Brain cancer
  3. * Bladder cancer
  4. * Urothelial cancer
  5. * Testicular cancer
  6. * Skin cancer
  7. * Thyroid cancer
  8. * Hepatocellular carcinoma
  9. * Cholangiocarcinoma
  10. * Thymus cancer
  11. * Pleural cancer
  12. * Cervical cancer
  13. * Adrenal cancer
  14. * Neuroendocrine tumors
  15. * Hematologic cancer
  16. * Cancer of Unkown Primary
  17. * Patients who are scheduled to undergo surgical resection or tissue biopsy of the primary tumor and/or metastasis
  18. * Patients are ≥ 18 years old at the time of the radiotracer administration.
  19. * Patient can provide written informed consent
  20. * Patient is able to remain still for duration of imaging procedure (up to one hour)
  1. * Patient is pregnant or nursing
  2. * Patients with any new cancer therapy between the baseline PET/CT and the investigational FAPI PET/CT
  3. * Patient has underlying disease which, based on the judgment of the investigator, might interfere with the collection of high quality data

Contacts and Locations

Principal Investigator

Jeremie Calais
PRINCIPAL_INVESTIGATOR
UCLA / Jonsson Comprehensive Cancer Center

Study Locations (Sites)

UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095
United States

Collaborators and Investigators

Sponsor: Jonsson Comprehensive Cancer Center

  • Jeremie Calais, PRINCIPAL_INVESTIGATOR, UCLA / Jonsson Comprehensive Cancer Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-08-27
Study Completion Date2027-07-01

Study Record Updates

Study Start Date2020-08-27
Study Completion Date2027-07-01

Terms related to this study

Additional Relevant MeSH Terms

  • Bladder Carcinoma
  • Cervical Carcinoma
  • Cholangiocarcinoma
  • Hematopoietic and Lymphoid Cell Neoplasm
  • Hepatocellular Carcinoma
  • Malignant Adrenal Gland Neoplasm
  • Malignant Brain Neoplasm
  • Malignant Pleural Neoplasm
  • Malignant Skin Neoplasm
  • Malignant Solid Neoplasm
  • Malignant Testicular Neoplasm
  • Malignant Thymus Neoplasm
  • Neuroendocrine Neoplasm
  • Thyroid Gland Carcinoma
  • Urothelial Carcinoma
  • Cancer of Unknown Primary Site