RECRUITING

Regulation of Mucosal Healing in Inflammatory Bowel Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The objective of the current study is to compare non-healing colonic ulcers in patients with inflammatory bowel disease (IBD) with iatrogenic colonic ulcers (biopsy sites) in healthy control patients and patients with rheumatoid or psoriatic arthritis. Patients will be biopsied at baseline and again at a follow-up visit in a "biopsy of the biopsy" approach. These biopsies will be used to reveal patterns about gene expression and mitochondrial function during ulcer healing.

Official Title

Regulation of Mucosal Healing in Inflammatory Bowel Disease

Quick Facts

Study Start:2021-04-30
Study Completion:2025-05-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04504136

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. * Classified in an anesthesia risk group, ASA Class =4
  2. * History of bleeding diathesis or coagulopathy
  3. * Stroke or transient neurological attack with the last 6 months
  4. * Pregnant
  5. * Receiving anticoagulants or anti-platelet medications other than low-dose aspirin
  6. * Receiving steroid therapy or metformin
  7. * HIV positive
  8. * Incarceration
  9. * History of total proctocolectomy
  10. * History of system chemotherapy within 18 months
  11. * Uncontrolled intercurrent illness

Contacts and Locations

Study Contact

Syed Adeel Hassan, MBBS/MD
CONTACT
312-340-4925
syed.hassan@uky.edu

Principal Investigator

Terrence Barrett, MD
PRINCIPAL_INVESTIGATOR
University of Kentucky

Study Locations (Sites)

University of Kentucky
Lexington, Kentucky, 40536
United States

Collaborators and Investigators

Sponsor: Terrence A Barrett

  • Terrence Barrett, MD, PRINCIPAL_INVESTIGATOR, University of Kentucky

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-04-30
Study Completion Date2025-05-01

Study Record Updates

Study Start Date2021-04-30
Study Completion Date2025-05-01

Terms related to this study

Keywords Provided by Researchers

  • mucosal
  • rheumatoid arthritis
  • psoriatic arthritis
  • ulcer
  • colitis
  • Crohn's
  • mitochondria
  • biopsy
  • wound
  • biologic
  • anti-TNF

Additional Relevant MeSH Terms

  • Inflammatory Bowel Diseases