ACTIVE_NOT_RECRUITING

Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial

Conditions

Prostate Adenocarcinoma Stage III Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This phase III trial compares less intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in treating patients with high risk prostate cancer and low gene risk score. This trial also compares more intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in patients with high risk prostate cancer and high gene risk score. Apalutamide may help fight prostate cancer by blocking the use of androgen by the tumor cells. Radiation therapy uses high energy rays to kill tumor cells and shrink tumors. Giving a shorter hormone therapy treatment may work the same at controlling prostate cancer compared to the usual 24 month hormone therapy treatment in patients with low gene risk score. Adding apalutamide to the usual treatment may increase the length of time without prostate cancer spreading as compared to the usual treatment in patients with high gene risk score.

Official Title

Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk With Radiation (PREDICT-RT*)

Quick Facts

Study Start:2021-01-21

Study Completion:2033-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04513717

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:MALE

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* PRIOR TO STEP 1 REGISTRATION * Pathologically proven diagnosis of adenocarcinoma of prostate cancer within 180 days prior to registration * High-risk disease defined as having at least one or more of the following: * PSA \> 20 ng/mL prior to starting ADT * Note: Patients receiving a 5-alpha reductase inhibitor (ex. finasteride) at the time of enrollment are eligible. The baseline PSA value should be doubled for PSAs taken while on 5-alpha reductase inhibitors and the medication should be discontinued prior to randomization but a washout period is not required * cT3a-T4 by digital exam or imaging (American Joint Committee on Cancer \[AJCC\] 8th edition \[Ed.\]) * Gleason score of 8-10 * Node positive by conventional imaging with a short axis of at least 1.0 cm * Appropriate stage for study entry based on the following diagnostic workup: * History/physical examination within 120 days prior to registration; * Bone imaging within 120 days prior to registration; * Note: To be eligible, patient must have no definitive evidence of bone metastases (M0) on bone scan or sodium fluoride (NaF) PET within 120 days prior to registration (negative NaF PET/CT or negative Axumin or choline PET or negative fluciclovine, choline or prostate-specific membrane antigen (PSMA) PET within 120 days prior to registration is an acceptable substitute if they have been performed). Patients who have bone metastases established only fluciclovine, choline, or PSMA PET but not definitive on bone scan or NaF PET will still be eligible * CT or MRI of the pelvis within 120 days prior to registration (negative fluciclovine, choline, or PSMA PET within 120 days prior to registration is an acceptable substitute). As with bone staging, nodal staging for trial purposes will be based off of conventional imaging findings only * Patients with confirmed N1 metastases on conventional imaging (CT/MRI) as defined by \>= 10 mm on short axis are eligible but will be automatically assigned to the intensification study. Patients who are positive by fluciclovine, choline, or PSMA PET (i.e. N1), but whose nodes do not meet traditional size criteria for positivity (i.e. they measure \>= 10 mm on either the CT or MRI portion of the PET or on a dedicated CT or MRI) will not be considered N1 for the trial and will not automatically be assigned to the intensification study * Age \>= 18 * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 within 120 days prior to registration * Hemoglobin \>= 9.0 g/dL, independent of transfusion and/or growth factors (within 120 days prior to registration) * Platelet count \>= 100 x 10\^3/uL independent of transfusion and/or growth factors (within 120 days prior to registration) * Creatinine clearance (CrCl) \>= 30 mL/min estimated by Cockcroft-Gault equation (within 120 days prior to registration) * For Black patients whose renal function is not considered adequate by Cockcroft-Gault formula, an alternative formula that takes race into account (Chronic Kidney Disease Epidemiology Collaboration CKD-EPI formula) may be used for calculating creatinine clearance for trial eligibility * Either a CrCl \>= 30 ml/min or calculated glomerular filtration rate (GFR) \>= 30 will make a patient eligible * Total bilirubin =\< 1.5 x institutional upper limit of normal (ULN) (within 120 days prior to registration) * Note: In subjects with Gilbert's syndrome, if total bilirubin is \> 1.5 x ULN, measure direct and indirect bilirubin and if direct bilirubin is =\< 1.5 x ULN, subject is eligible * Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\]) or alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 x institutional ULN (within 120 days prior to registration) * Serum albumin \>= 3.0 g/dL (within 120 days prior to registration) * The patient must agree to use a condom (even men with vasectomies) and another effective method of birth control if he is having sex with a woman of childbearing potential or agree to use a condom if he is having sex with a woman who is pregnant while on study drug and for 3 months following the last dose of study drug * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial and have a CD4 count \>= 200 cells/microliter within 60 days prior to registration. Note: HIV testing is not required for eligibility for this protocol. Of note, for patients with HIV in the intensification trial randomized to apalutamide, highly active antiretroviral therapy (HAART) may need to be adjusted to medications that do not interact with apalutamide * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable after or on suppressive therapy within 60 days prior to registration, if indicated. Note: HBV viral testing is not required for eligibility for this protocol * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial. Note: Any patient with a cancer (other than keratinocyte carcinoma or carcinoma in situ or low-grade non-muscle invasive bladder cancer) who has been disease-free for less than 3 years must contact the principal investigator * The patient or a legally authorized representative must provide study-specific informed consent prior to study entry * PRIOR TO STEP 2 RANDOMIZATION * Confirmation of Decipher score * Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load within 60 days prior. Note: Apalutamide may interfere with HCV drugs. Patients on HCV medications should alert their infectious diseases physician if they get randomized to apalutamide due to the possibility that apalutamide can affect the bioavailability of some HCV medications. HCV viral testing is not required for eligibility for this protocol * For patients entering the Intensification Cohort ONLY: Patients must discontinue or substitute concomitant medications known to lower the seizure threshold at least 30 days prior to Step 2 randomization	* PRIOR TO STEP 1 REGISTRATION: * Definitive radiologic evidence of metastatic disease outside of the pelvic nodes (M1a, M1b or M1c) on conventional imaging (i.e. bone scan, CT scan, MRI) * Prior systemic chemotherapy within =\< 3 years prior to registration; note that prior chemotherapy for a different cancer is allowed (completed \> 3 years prior to registration * Prior radical prostatectomy * Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields * Current use of 5-alpha reductase inhibitor. NOTE: If the alpha reductase inhibitor is stopped prior to randomization the patient is eligible * History of any of the following: * Seizure disorder * Current severe or unstable angina * New York Heart Association Functional Classification III/IV (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification.) * History of any condition that in the opinion of the investigator, would preclude participation in this study * Evidence of any of the following at registration: * Active uncontrolled infection requiring IV antibiotics * Baseline severe hepatic impairment (Child Pugh Class C) * Inability to swallow oral pills * Any current condition that in the opinion of the investigator, would preclude participation in this study * Prior pharmacologic androgen ablation for prostate cancer is allowed only if the onset of androgen ablation (both luteinizing hormone-releasing hormone \[LHRH\] agonist and oral anti-androgen) is =\< 60 days prior to registration; Please note: baseline PSA must be obtained prior to the start of any ADT * PRIOR TO STEP 2 RANDOMIZATION: * Evidence of known gastrointestinal disorder affecting absorption of oral medications at registration * For patients entering the Intensification Cohort ONLY: Presence of uncontrolled hypertension (persistent systolic blood pressure \[BP\] \>= 160 mmHg or diastolic BP \>= 100 mmHg). Subjects with a history of hypertension are allowed, provided that BP is controlled to within these limits by anti-hypertensive treatment

Inclusion Criteria

Exclusion Criteria

* PRIOR TO STEP 1 REGISTRATION
* Pathologically proven diagnosis of adenocarcinoma of prostate cancer within 180 days prior to registration
* High-risk disease defined as having at least one or more of the following:
* PSA \> 20 ng/mL prior to starting ADT
* Note: Patients receiving a 5-alpha reductase inhibitor (ex. finasteride) at the time of enrollment are eligible. The baseline PSA value should be doubled for PSAs taken while on 5-alpha reductase inhibitors and the medication should be discontinued prior to randomization but a washout period is not required
* cT3a-T4 by digital exam or imaging (American Joint Committee on Cancer \[AJCC\] 8th edition \[Ed.\])
* Gleason score of 8-10
* Node positive by conventional imaging with a short axis of at least 1.0 cm
* Appropriate stage for study entry based on the following diagnostic workup:
* History/physical examination within 120 days prior to registration;
* Bone imaging within 120 days prior to registration;
* Note: To be eligible, patient must have no definitive evidence of bone metastases (M0) on bone scan or sodium fluoride (NaF) PET within 120 days prior to registration (negative NaF PET/CT or negative Axumin or choline PET or negative fluciclovine, choline or prostate-specific membrane antigen (PSMA) PET within 120 days prior to registration is an acceptable substitute if they have been performed). Patients who have bone metastases established only fluciclovine, choline, or PSMA PET but not definitive on bone scan or NaF PET will still be eligible
* CT or MRI of the pelvis within 120 days prior to registration (negative fluciclovine, choline, or PSMA PET within 120 days prior to registration is an acceptable substitute). As with bone staging, nodal staging for trial purposes will be based off of conventional imaging findings only
* Patients with confirmed N1 metastases on conventional imaging (CT/MRI) as defined by \>= 10 mm on short axis are eligible but will be automatically assigned to the intensification study. Patients who are positive by fluciclovine, choline, or PSMA PET (i.e. N1), but whose nodes do not meet traditional size criteria for positivity (i.e. they measure \>= 10 mm on either the CT or MRI portion of the PET or on a dedicated CT or MRI) will not be considered N1 for the trial and will not automatically be assigned to the intensification study
* Age \>= 18
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 within 120 days prior to registration
* Hemoglobin \>= 9.0 g/dL, independent of transfusion and/or growth factors (within 120 days prior to registration)
* Platelet count \>= 100 x 10\^3/uL independent of transfusion and/or growth factors (within 120 days prior to registration)
* Creatinine clearance (CrCl) \>= 30 mL/min estimated by Cockcroft-Gault equation (within 120 days prior to registration)
* For Black patients whose renal function is not considered adequate by Cockcroft-Gault formula, an alternative formula that takes race into account (Chronic Kidney Disease Epidemiology Collaboration CKD-EPI formula) may be used for calculating creatinine clearance for trial eligibility
* Either a CrCl \>= 30 ml/min or calculated glomerular filtration rate (GFR) \>= 30 will make a patient eligible
* Total bilirubin =\< 1.5 x institutional upper limit of normal (ULN) (within 120 days prior to registration)
* Note: In subjects with Gilbert's syndrome, if total bilirubin is \> 1.5 x ULN, measure direct and indirect bilirubin and if direct bilirubin is =\< 1.5 x ULN, subject is eligible
* Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\]) or alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 x institutional ULN (within 120 days prior to registration)
* Serum albumin \>= 3.0 g/dL (within 120 days prior to registration)
* The patient must agree to use a condom (even men with vasectomies) and another effective method of birth control if he is having sex with a woman of childbearing potential or agree to use a condom if he is having sex with a woman who is pregnant while on study drug and for 3 months following the last dose of study drug
* Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial and have a CD4 count \>= 200 cells/microliter within 60 days prior to registration. Note: HIV testing is not required for eligibility for this protocol. Of note, for patients with HIV in the intensification trial randomized to apalutamide, highly active antiretroviral therapy (HAART) may need to be adjusted to medications that do not interact with apalutamide
* For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable after or on suppressive therapy within 60 days prior to registration, if indicated. Note: HBV viral testing is not required for eligibility for this protocol
* Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial. Note: Any patient with a cancer (other than keratinocyte carcinoma or carcinoma in situ or low-grade non-muscle invasive bladder cancer) who has been disease-free for less than 3 years must contact the principal investigator
* The patient or a legally authorized representative must provide study-specific informed consent prior to study entry
* PRIOR TO STEP 2 RANDOMIZATION
* Confirmation of Decipher score
* Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load within 60 days prior. Note: Apalutamide may interfere with HCV drugs. Patients on HCV medications should alert their infectious diseases physician if they get randomized to apalutamide due to the possibility that apalutamide can affect the bioavailability of some HCV medications. HCV viral testing is not required for eligibility for this protocol
* For patients entering the Intensification Cohort ONLY: Patients must discontinue or substitute concomitant medications known to lower the seizure threshold at least 30 days prior to Step 2 randomization

* PRIOR TO STEP 1 REGISTRATION:
* Definitive radiologic evidence of metastatic disease outside of the pelvic nodes (M1a, M1b or M1c) on conventional imaging (i.e. bone scan, CT scan, MRI)
* Prior systemic chemotherapy within =\< 3 years prior to registration; note that prior chemotherapy for a different cancer is allowed (completed \> 3 years prior to registration
* Prior radical prostatectomy
* Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
* Current use of 5-alpha reductase inhibitor. NOTE: If the alpha reductase inhibitor is stopped prior to randomization the patient is eligible
* History of any of the following:
* Seizure disorder
* Current severe or unstable angina
* New York Heart Association Functional Classification III/IV (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification.)
* History of any condition that in the opinion of the investigator, would preclude participation in this study
* Evidence of any of the following at registration:
* Active uncontrolled infection requiring IV antibiotics
* Baseline severe hepatic impairment (Child Pugh Class C)
* Inability to swallow oral pills
* Any current condition that in the opinion of the investigator, would preclude participation in this study
* Prior pharmacologic androgen ablation for prostate cancer is allowed only if the onset of androgen ablation (both luteinizing hormone-releasing hormone \[LHRH\] agonist and oral anti-androgen) is =\< 60 days prior to registration; Please note: baseline PSA must be obtained prior to the start of any ADT
* PRIOR TO STEP 2 RANDOMIZATION:
* Evidence of known gastrointestinal disorder affecting absorption of oral medications at registration
* For patients entering the Intensification Cohort ONLY: Presence of uncontrolled hypertension (persistent systolic blood pressure \[BP\] \>= 160 mmHg or diastolic BP \>= 100 mmHg). Subjects with a history of hypertension are allowed, provided that BP is controlled to within these limits by anti-hypertensive treatment

Contacts and Locations

Principal Investigator

Paul L Nguyen

PRINCIPAL_INVESTIGATOR

NRG Oncology

Study Locations (Sites)

Fairbanks Memorial Hospital

Fairbanks, Alaska, 99701

United States

Arizona Center for Cancer Care - Gilbert

Gilbert, Arizona, 85297

United States

Arizona Center for Cancer Care-Peoria

Peoria, Arizona, 85381

United States

Arizona Center for Cancer Care - Phoenix

Phoenix, Arizona, 85027

United States

Arizona Center for Cancer Care - Scottsdale

Scottsdale, Arizona, 85258

United States

University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719

United States

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205

United States

Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603

United States

AIS Cancer Center at San Joaquin Community Hospital

Bakersfield, California, 93301

United States

Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, 94704

United States

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, 95682

United States

Enloe Medical Center

Chico, California, 95926

United States

City of Hope Corona

Corona, California, 92882

United States

City of Hope Comprehensive Cancer Center

Duarte, California, 91010

United States

Kaiser Permanente Dublin

Dublin, California, 94568

United States

UC San Diego Health System - Encinitas

Encinitas, California, 92024

United States

Kaiser Permanente-Fremont

Fremont, California, 94538

United States

Palo Alto Medical Foundation-Fremont

Fremont, California, 94538

United States

Washington Hospital

Fremont, California, 94538

United States

Kaiser Permanente-Fresno

Fresno, California, 93720

United States

Marin General Hospital

Greenbrae, California, 94904

United States

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, California, 92612

United States

City of Hope at Irvine Lennar

Irvine, California, 92618

United States

UC San Diego Moores Cancer Center

La Jolla, California, 92093

United States

City of Hope Antelope Valley

Lancaster, California, 93534

United States

Los Angeles General Medical Center

Los Angeles, California, 90033

United States

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033

United States

Cedars Sinai Medical Center

Los Angeles, California, 90048

United States

Fremont - Rideout Cancer Center

Marysville, California, 95901

United States

Memorial Medical Center

Modesto, California, 95355

United States

Kaiser Permanente-Modesto

Modesto, California, 95356

United States

Providence Queen of The Valley

Napa, California, 94558

United States

Kaiser Permanente-Oakland

Oakland, California, 94611

United States

Saint Joseph Hospital - Orange

Orange, California, 92868

United States

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868

United States

Palo Alto Medical Foundation Health Care

Palo Alto, California, 94301

United States

Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304

United States

Kaiser Permanente-Roseville

Roseville, California, 95661

United States

Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661

United States

Kaiser Permanente Downtown Commons

Sacramento, California, 95814

United States

Sutter Medical Center Sacramento

Sacramento, California, 95816

United States

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817

United States

Kaiser Permanente-South Sacramento

Sacramento, California, 95823

United States

California Protons Cancer Therapy Center

San Diego, California, 92121

United States

Sharp Memorial Hospital

San Diego, California, 92123

United States

Kaiser Permanente-San Francisco

San Francisco, California, 94115

United States

UCSF Medical Center-Mission Bay

San Francisco, California, 94158

United States

Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119

United States

Stanford Cancer Center South Bay

San Jose, California, 95124

United States

Kaiser Permanente San Leandro

San Leandro, California, 94577

United States

UCSF Cancer Center - San Mateo

San Mateo, California, 94402

United States

Ridley-Tree Cancer Center

Santa Barbara, California, 93105

United States

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051

United States

Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403

United States

City of Hope South Pasadena

South Pasadena, California, 91030

United States

Kaiser Permanente-South San Francisco

South San Francisco, California, 94080

United States

Palo Alto Medical Foundation-Sunnyvale

Sunnyvale, California, 94086

United States

Cedars-Sinai Cancer - Tarzana

Tarzana, California, 91356

United States

City of Hope South Bay

Torrance, California, 90503

United States

Torrance Memorial Physician Network - Cancer Care

Torrance, California, 90505

United States

Torrance Memorial Medical Center

Torrance, California, 90509

United States

Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, 96161

United States

City of Hope Upland

Upland, California, 91786

United States

Kaiser Permanente-Vallejo

Vallejo, California, 94589

United States

Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596

United States

BASS Medical Group - Lennon

Walnut Creek, California, 94598

United States

John Muir Medical Center-Walnut Creek

Walnut Creek, California, 94598

United States

UCHealth University of Colorado Hospital

Aurora, Colorado, 80045

United States

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304

United States

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909

United States

Memorial Hospital North

Colorado Springs, Colorado, 80920

United States

Shaw Cancer Center

Edwards, Colorado, 81632

United States

Poudre Valley Hospital

Fort Collins, Colorado, 80524

United States

Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, 80528

United States

Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81501

United States

Banner North Colorado Medical Center

Greeley, Colorado, 80631

United States

UCHealth Greeley Hospital

Greeley, Colorado, 80631

United States

UCHealth Highlands Ranch Hospital

Highlands Ranch, Colorado, 80129

United States

Medical Center of the Rockies

Loveland, Colorado, 80538

United States

Banner McKee Medical Center

Loveland, Colorado, 80539

United States

Hartford HealthCare - Saint Vincent's Medical Center

Bridgeport, Connecticut, 06606

United States

Smilow Cancer Hospital-Derby Care Center

Derby, Connecticut, 06418

United States

Smilow Cancer Hospital Care Center-Fairfield

Fairfield, Connecticut, 06824

United States

Smilow Cancer Hospital Care Center at Greenwich

Greenwich, Connecticut, 06830

United States

Smilow Cancer Hospital Care Center - Guilford

Guilford, Connecticut, 06437

United States

Hartford Hospital

Hartford, Connecticut, 06102

United States

Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105

United States

Midstate Medical Center

Meriden, Connecticut, 06451

United States

The Hospital of Central Connecticut

New Britain, Connecticut, 06050

United States

Yale University

New Haven, Connecticut, 06520

United States

Yale-New Haven Hospital North Haven Medical Center

North Haven, Connecticut, 06473

United States

Smilow Cancer Hospital-Orange Care Center

Orange, Connecticut, 06477

United States

Smilow Cancer Hospital Care Center at Long Ridge

Stamford, Connecticut, 06902

United States

Stamford Hospital/Bennett Cancer Center

Stamford, Connecticut, 06904

United States

Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611

United States

Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385

United States

Bayhealth Hospital Kent Campus

Dover, Delaware, 19901

United States

Helen F Graham Cancer Center

Newark, Delaware, 19713

United States

Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713

United States

Mount Sinai Comprehensive Cancer Center at Aventura

Aventura, Florida, 33180

United States

Bay Pines VA Healthcare System

Bay Pines, Florida, 33744

United States

Boca Raton Regional Hospital

Boca Raton, Florida, 33486

United States

University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610

United States

Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980

United States

GenesisCare USA - Lakewood Ranch

Lakewood Rch, Florida, 34202

United States

Miami Cancer Institute

Miami, Florida, 33176

United States

Mount Sinai Medical Center

Miami Beach, Florida, 33140

United States

GenesisCare USA - Plantation

Plantation, Florida, 33324

United States

Miami Cancer Institute at Plantation

Plantation, Florida, 33324

United States

Tampa General Hospital

Tampa, Florida, 33606

United States

Grady Health System

Atlanta, Georgia, 30303

United States

Emory Proton Therapy Center

Atlanta, Georgia, 30308

United States

Emory University Hospital Midtown

Atlanta, Georgia, 30308

United States

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322

United States

Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342

United States

Emory Decatur Hospital

Decatur, Georgia, 30033

United States

Emory Johns Creek Hospital

Johns Creek, Georgia, 30097

United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405

United States

Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813

United States

Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813

United States

Queen's Medical Center

Honolulu, Hawaii, 96813

United States

Straub Clinic and Hospital

Honolulu, Hawaii, 96813

United States

University of Hawaii Cancer Center

Honolulu, Hawaii, 96813

United States

Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817

United States

The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817

United States

Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701

United States

Pali Momi Medical Center

‘Aiea, Hawaii, 96701

United States

The Cancer Center of Hawaii-Pali Momi

‘Aiea, Hawaii, 96701

United States

The Queen's Medical Center - West Oahu

‘Ewa Beach, Hawaii, 96706

United States

Alton Memorial Hospital

Alton, Illinois, 62002

United States

Rush-Copley Medical Center

Aurora, Illinois, 60504

United States

Advocate Good Shepherd Hospital

Barrington, Illinois, 60010

United States

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704

United States

Illinois CancerCare-Canton

Canton, Illinois, 61520

United States

Illinois CancerCare-Carthage

Carthage, Illinois, 62321

United States

Northwestern University

Chicago, Illinois, 60611

United States

Rush University Medical Center

Chicago, Illinois, 60612

United States

University of Illinois

Chicago, Illinois, 60612

United States

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637

United States

Advocate Illinois Masonic Medical Center

Chicago, Illinois, 60657

United States

AMG Crystal Lake - Oncology

Crystal Lake, Illinois, 60014

United States

Carle at The Riverfront

Danville, Illinois, 61832

United States

Decatur Memorial Hospital

Decatur, Illinois, 62526

United States

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, 60115

United States

Advocate Good Samaritan Hospital

Downers Grove, Illinois, 60515

United States

Crossroads Cancer Center

Effingham, Illinois, 62401

United States

Advocate Sherman Hospital

Elgin, Illinois, 60123

United States

Elmhurst Memorial Hospital

Elmhurst, Illinois, 60126

United States

Illinois CancerCare-Eureka

Eureka, Illinois, 61530

United States

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401

United States

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134

United States

Northwestern Medicine Glenview Outpatient Center

Glenview, Illinois, 60026

United States

Northwestern Medicine Grayslake Outpatient Center

Grayslake, Illinois, 60030

United States

Ingalls Memorial Hospital

Harvey, Illinois, 60426

United States

Advocate South Suburban Hospital

Hazel Crest, Illinois, 60429

United States

Edward Hines Jr VA Hospital

Hines, Illinois, 60141

United States

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443

United States

Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045

United States

AMG Libertyville - Oncology

Libertyville, Illinois, 60048

United States

Condell Memorial Hospital

Libertyville, Illinois, 60048

United States

Illinois CancerCare-Macomb

Macomb, Illinois, 61455

United States

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938

United States

Loyola University Medical Center

Maywood, Illinois, 60153

United States

Edward Hospital/Cancer Center

Naperville, Illinois, 60540

United States

UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, 60451

United States

HSHS Saint Elizabeth's Hospital

O'Fallon, Illinois, 62269

United States

Northwestern Medicine Oak Brook

Oak Brook, Illinois, 60523

United States

Advocate Christ Medical Center

Oak Lawn, Illinois, 60453-2699

United States

Northwestern Medicine Orland Park

Orland Park, Illinois, 60462

United States

University of Chicago Medicine-Orland Park

Orland Park, Illinois, 60462

United States

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350

United States

Advocate High Tech Medical Park

Palos Heights, Illinois, 60463

United States

Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068

United States

Illinois CancerCare-Pekin

Pekin, Illinois, 61554

United States

Illinois CancerCare-Peoria

Peoria, Illinois, 61615

United States

Methodist Medical Center of Illinois

Peoria, Illinois, 61636

United States

OSF Saint Francis Medical Center

Peoria, Illinois, 61637

United States

Illinois CancerCare-Peru

Peru, Illinois, 61354

United States

Edward Hospital/Cancer Center?Plainfield

Plainfield, Illinois, 60585

United States

Illinois CancerCare-Princeton

Princeton, Illinois, 61356

United States

UW Health Carbone Cancer Center Rockford

Rockford, Illinois, 61114

United States

Memorial Hospital East

Shiloh, Illinois, 62269

United States

Springfield Memorial Hospital

Springfield, Illinois, 62781

United States

Carle Cancer Center

Urbana, Illinois, 61801

United States

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555

United States

Illinois CancerCare - Washington

Washington, Illinois, 61571

United States

IU Health West Hospital

Avon, Indiana, 46123

United States

IU Health North Hospital

Carmel, Indiana, 46032

United States

UChicago Medicine Northwest Indiana

Crown Point, Indiana, 46307

United States

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202

United States

IU Health Methodist Hospital

Indianapolis, Indiana, 46202

United States

UI Health Care Mission Cancer and Blood - Ankeny Clinic

Ankeny, Iowa, 50023

United States

Saint Luke's Hospital

Cedar Rapids, Iowa, 52402

United States

Mercy Hospital

Cedar Rapids, Iowa, 52403

United States

Oncology Associates at Mercy Medical Center

Cedar Rapids, Iowa, 52403

United States

Iowa Methodist Medical Center

Des Moines, Iowa, 50309

United States

UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309

United States

Broadlawns Medical Center

Des Moines, Iowa, 50314

United States

University of Kansas Cancer Center

Kansas City, Kansas, 66160

United States

The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061

United States

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210

United States

Salina Regional Health Center

Salina, Kansas, 67401

United States

University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606

United States

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205

United States

Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214

United States

Wesley Medical Center

Wichita, Kansas, 67214

United States

Saint Joseph Hospital East

Lexington, Kentucky, 40509

United States

The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202

United States

UofL Health Medical Center Northeast

Louisville, Kentucky, 40245

United States

Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809

United States

Mary Bird Perkins Cancer Center - Metairie

Metairie, Louisiana, 70002

United States

East Jefferson General Hospital

Metairie, Louisiana, 70006

United States

LSU Healthcare Network / Metairie Multi-Specialty Clinic

Metairie, Louisiana, 70006

United States

Tulane University School of Medicine

New Orleans, Louisiana, 70112

United States

MaineHealth Coastal Cancer Treatment Center

Bath, Maine, 04530

United States

MaineHealth Maine Medical Center - Portland

Portland, Maine, 04102

United States

Penobscot Bay Medical Center

Rockport, Maine, 04856

United States

MaineHealth Cancer Care Center of York County

Sanford, Maine, 04073

United States

MaineHealth Maine Medical Center- Scarborough

Scarborough, Maine, 04074

United States

MaineHealth Cancer Care and IV Therapy - South Portland

South Portland, Maine, 04106

United States

Luminis Health Anne Arundel Medical Center

Annapolis, Maryland, 21401

United States

Maryland Proton Treatment Center

Baltimore, Maryland, 21201

United States

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201

United States

Veterans Administration Medical Center-Baltimore

Baltimore, Maryland, 21201

United States

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287

United States

UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014

United States

Suburban Hospital

Bethesda, Maryland, 20814

United States

University of Maryland Shore Medical Center at Easton

Easton, Maryland, 21601

United States

UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061

United States

UM Capital Region Medical Center

Largo, Maryland, 20774

United States

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114

United States

Brigham and Women's Hospital

Boston, Massachusetts, 02115

United States

Boston Medical Center

Boston, Massachusetts, 02118

United States

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215

United States

Cape Cod Hospital

Hyannis, Massachusetts, 02601

United States

Dana-Farber/Brigham and Women's Cancer Center at Milford Regional

Milford, Massachusetts, 01757

United States

Dana-Farber/Brigham and Women's Cancer Center at South Shore

South Weymouth, Massachusetts, 02190

United States

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106

United States

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109

United States

McLaren Cancer Institute-Bay City

Bay City, Michigan, 48706

United States

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114

United States

Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114

United States

University of Michigan - Brighton Center for Specialty Care

Brighton, Michigan, 48116

United States

Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183

United States

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188

United States

Trinity Health Medical Center - Canton

Canton, Michigan, 48188

United States

Chelsea Hospital

Chelsea, Michigan, 48118

United States

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118

United States

McLaren Cancer Institute-Clarkston

Clarkston, Michigan, 48346

United States

Michigan Healthcare Professionals Clarkston

Clarkston, Michigan, 48346

United States

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038

United States

Corewell Health Dearborn Hospital

Dearborn, Michigan, 48124

United States

Henry Ford Medical Center-Fairlane

Dearborn, Michigan, 48126

United States

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201

United States

Henry Ford Hospital

Detroit, Michigan, 48202

United States

Michigan Healthcare Professionals Farmington

Farmington Hills, Michigan, 48334

United States

Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334

United States

Genesys Hurley Cancer Institute

Flint, Michigan, 48503

United States

McLaren Cancer Institute-Flint

Flint, Michigan, 48532

United States

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503

United States

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503

United States

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007

United States

West Michigan Cancer Center

Kalamazoo, Michigan, 49007

United States

Karmanos Cancer Institute at McLaren Greater Lansing

Lansing, Michigan, 48910

United States

University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912

United States

McLaren Cancer Institute-Lapeer Region

Lapeer, Michigan, 48446

United States

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154

United States

Michigan Healthcare Professionals Macomb

Macomb, Michigan, 48044

United States

Michigan Healthcare Professionals Madison Heights

Madison Heights, Michigan, 48071

United States

McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043

United States

McLaren Cancer Institute-Central Michigan

Mount Pleasant, Michigan, 48858

United States

Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120

United States

Henry Ford Medical Center-Columbus

Novi, Michigan, 48377

United States

McLaren-Port Huron

Port Huron, Michigan, 48060

United States

Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073

United States

MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601

United States

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085

United States

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085

United States

Henry Ford Macomb Health Center - Shelby Township

Shelby, Michigan, 48315

United States

Munson Medical Center

Traverse City, Michigan, 49684

United States

Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085

United States

Michigan Healthcare Professionals Troy

Troy, Michigan, 48098

United States

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322

United States

University of Michigan Health - West

Wyoming, Michigan, 49519

United States

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197

United States

Mayo Clinic Health System in Albert Lea

Albert Lea, Minnesota, 56007

United States

Mercy Hospital

Coon Rapids, Minnesota, 55433

United States

Miller-Dwan Hospital

Duluth, Minnesota, 55805

United States

Unity Hospital

Fridley, Minnesota, 55432

United States

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109

United States

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407

United States

Hennepin County Medical Center

Minneapolis, Minnesota, 55415

United States

Monticello Cancer Center

Monticello, Minnesota, 55362

United States

Mayo Clinic in Rochester

Rochester, Minnesota, 55905

United States

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416

United States

Regions Hospital

Saint Paul, Minnesota, 55101

United States

University of Mississippi Medical Center

Jackson, Mississippi, 39216

United States

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703

United States

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376

United States

MU Health - University Hospital/Ellis Fischel Cancer Center

Columbia, Missouri, 65212

United States

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141

United States

Parkland Health Center - Farmington

Farmington, Missouri, 63640

United States

Freeman Health System

Joplin, Missouri, 64804

United States

University of Kansas Cancer Center - North

Kansas City, Missouri, 64154

United States

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064

United States

University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116

United States

Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401

United States

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670

United States

Mercy Hospital Springfield

Springfield, Missouri, 65804

United States

Washington University School of Medicine

St Louis, Missouri, 63110

United States

Siteman Cancer Center-South County

St Louis, Missouri, 63129

United States

Missouri Baptist Medical Center

St Louis, Missouri, 63131

United States

Siteman Cancer Center at Christian Hospital

St Louis, Missouri, 63136

United States

Mercy Hospital Saint Louis

St Louis, Missouri, 63141

United States

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080

United States

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127

United States

Billings Clinic Cancer Center

Billings, Montana, 59101

United States

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405

United States

Nebraska Medicine-Bellevue

Bellevue, Nebraska, 68123

United States

Nebraska Medicine-Village Pointe

Omaha, Nebraska, 68118

United States

University of Nebraska Medical Center

Omaha, Nebraska, 68198

United States

New Hampshire Oncology Hematology PA-Concord

Concord, New Hampshire, 03301

United States

Exeter Hospital

Exeter, New Hampshire, 03833

United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756

United States

Solinsky Center for Cancer Care

Manchester, New Hampshire, 03103

United States

Clara Maass Medical Center

Belleville, New Jersey, 07109

United States

Cooper Hospital University Medical Center

Camden, New Jersey, 08103

United States

AtlantiCare Surgery Center

Egg Harbor, New Jersey, 08234

United States

Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus

Elizabeth, New Jersey, 07207

United States

Englewood Hospital and Medical Center

Englewood, New Jersey, 07631

United States

The Cancer Institute of New Jersey Hamilton

Hamilton, New Jersey, 08690

United States

Jersey City Medical Center

Jersey City, New Jersey, 07302

United States

Saint Barnabas Medical Center

Livingston, New Jersey, 07039

United States

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903

United States

Rutgers New Jersey Medical School

Newark, New Jersey, 07101

United States

Newark Beth Israel Medical Center

Newark, New Jersey, 07112

United States

The Valley Hospital - Luckow Pavilion

Paramus, New Jersey, 07652

United States

Valley Health System Ridgewood Campus

Ridgewood, New Jersey, 07450

United States

Sidney Kimmel Cancer Center Washington Township

Sewell, New Jersey, 08080

United States

Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, 08876

United States

Community Medical Center

Toms River, New Jersey, 08755

United States

MD Anderson Cancer Center at Cooper-Voorhees

Voorhees Township, New Jersey, 08043

United States

Lovelace Medical Center-Saint Joseph Square

Albuquerque, New Mexico, 87102

United States

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106

United States

Lovelace Radiation Oncology

Albuquerque, New Mexico, 87109

United States

Presbyterian Kaseman Hospital

Albuquerque, New Mexico, 87110

United States

Presbyterian Rust Medical Center/Jorgensen Cancer Center

Rio Rancho, New Mexico, 87124

United States

Northwell Health Imbert Cancer Center

Bay Shore, New York, 11706

United States

New York-Presbyterian/Brooklyn Methodist Hospital

Brooklyn, New York, 11215

United States

Roswell Park Cancer Institute

Buffalo, New York, 14263

United States

Sands Cancer Center

Canandaigua, New York, 14424

United States

Mary Imogene Bassett Hospital

Cooperstown, New York, 13326

United States

Noyes Memorial Hospital/Myers Cancer Center

Dansville, New York, 14437

United States

The New York Hospital Medical Center of Queens

Flushing, New York, 11355

United States

Northwell Health Physicians Partners Radiation Medicine at Queens

Forest Hills, New York, 11375

United States

Glens Falls Hospital

Glens Falls, New York, 12801

United States

Northwell Health Cancer Institute at Huntington

Greenlawn, New York, 11740

United States

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042

United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016

United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032

United States

Manhattan Eye Ear and Throat Hospital

New York, New York, 10065

United States

NYP/Weill Cornell Medical Center

New York, New York, 10065

United States

Lenox Hill Hospital

New York, New York, 10075

United States

Queens Cancer Center

Rego Park, New York, 11374

United States

Highland Hospital

Rochester, New York, 14620

United States

University of Rochester

Rochester, New York, 14642

United States

Phelps Memorial Hospital Center

Sleepy Hollow, New York, 10591

United States

Staten Island University Hospital

Staten Island, New York, 10305

United States

Stony Brook University Medical Center

Stony Brook, New York, 11794

United States

State University of New York Upstate Medical University

Syracuse, New York, 13210

United States

Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461

United States

Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467

United States

Westchester Medical Center

Valhalla, New York, 10595

United States

Wilmot Cancer Institute at Webster

Webster, New York, 14580

United States

Duke Cancer Center Cary

Cary, North Carolina, 27518

United States

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203

United States

Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204

United States

Atrium Health Pineville/LCI-Pineville

Charlotte, North Carolina, 28210

United States

Atrium Health University City/LCI-University

Charlotte, North Carolina, 28262

United States

Levine Cancer Institute-Ballantyne

Charlotte, North Carolina, 28277

United States

Atrium Health Cabarrus/LCI-Concord

Concord, North Carolina, 28025

United States

Durham VA Medical Center

Durham, North Carolina, 27705

United States

Duke University Medical Center

Durham, North Carolina, 27710

United States

Novant Health Cancer Institute - Huntersville

Huntersville, North Carolina, 28078

United States

Novant Health Presbyterian Medical Center Huntersville

Huntersville, North Carolina, 28078

United States

Matthews Radiation Oncology Center

Matthews, North Carolina, 28105

United States

Novant Health Cancer Institute - Matthews

Matthews, North Carolina, 28105

United States

Atrium Health Union/LCI-Union

Monroe, North Carolina, 28112

United States

Novant Health Cancer Institute - Mooresville

Mooresville, North Carolina, 28117

United States

UNC Rex Healthcare

Raleigh, North Carolina, 27607

United States

Duke Cancer Center Raleigh

Raleigh, North Carolina, 27609

United States

UNC Rex Cancer Center of Wakefield

Raleigh, North Carolina, 27614

United States

Novant Cancer Institute Radiation Oncology - Supply

Supply, North Carolina, 28462

United States

Novant Health Cancer Institute Radiation Oncology - Wilmington

Wilmington, North Carolina, 28401

United States

Novant Health New Hanover Regional Medical Center

Wilmington, North Carolina, 28401

United States

Novant Health Forsyth Medical Center

Winston-Salem, North Carolina, 27103

United States

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157

United States

Altru Cancer Center

Grand Forks, North Dakota, 58201

United States

Summa Health System - Akron Campus

Akron, Ohio, 44304

United States

Cleveland Clinic Akron General

Akron, Ohio, 44307

United States

Summa Health System - Barberton Campus

Barberton, Ohio, 44203

United States

Aultman Health Foundation

Canton, Ohio, 44710

United States

Adena Regional Medical Center

Chillicothe, Ohio, 45601

United States

The Christ Hospital

Cincinnati, Ohio, 45219

United States

MetroHealth Medical Center

Cleveland, Ohio, 44109

United States

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

United States

Riverside Methodist Hospital

Columbus, Ohio, 43214

United States

Grant Medical Center

Columbus, Ohio, 43215

United States

Doctors Hospital

Columbus, Ohio, 43228

United States

Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015

United States

Dublin Methodist Hospital

Dublin, Ohio, 43016

United States

OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903

United States

OhioHealth Marion General Hospital

Marion, Ohio, 43302

United States

Summa Health Medina Medical Center

Medina, Ohio, 44256

United States

ProMedica Flower Hospital

Sylvania, Ohio, 43560

United States

Cancer Centers of Southwest Oklahoma Research

Lawton, Oklahoma, 73505

United States

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

United States

Saint Charles Health System

Bend, Oregon, 97701

United States

Legacy Mount Hood Medical Center

Gresham, Oregon, 97030

United States

Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045

United States

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210

United States

Providence Portland Medical Center

Portland, Oregon, 97213

United States

Providence Saint Vincent Medical Center

Portland, Oregon, 97225

United States

Legacy Meridian Park Hospital

Tualatin, Oregon, 97062

United States

Saint Luke's Cancer Center - Allentown

Allentown, Pennsylvania, 18104

United States

UPMC Altoona

Altoona, Pennsylvania, 16601

United States

UPMC-Heritage Valley Health System Beaver

Beaver, Pennsylvania, 15009

United States

Saint Luke's University Hospital-Bethlehem Campus

Bethlehem, Pennsylvania, 18015

United States

Crozer-Keystone Regional Cancer Center at Broomall

Broomall, Pennsylvania, 19008

United States

Carlisle Regional Cancer Center

Carlisle, Pennsylvania, 17015

United States

Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317

United States

Chambersburg Hospital

Chambersburg, Pennsylvania, 17201

United States

Geisinger Medical Center

Danville, Pennsylvania, 17822

United States

Delaware County Memorial Hospital

Drexel Hill, Pennsylvania, 19026

United States

Saint Luke's Hospital-Anderson Campus

Easton, Pennsylvania, 18045

United States

Ephrata Cancer Center

Ephrata, Pennsylvania, 17522

United States

UPMC Hillman Cancer Center Erie

Erie, Pennsylvania, 16505

United States

Saint Vincent Hospital

Erie, Pennsylvania, 16544

United States

UPMC Cancer Center at UPMC Horizon

Farrell, Pennsylvania, 16121

United States

Adams Cancer Center

Gettysburg, Pennsylvania, 17325

United States

Crozer Regional Cancer Center at Brinton Lake

Glen Mills, Pennsylvania, 19342

United States

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, 15601

United States

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109

United States

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850

United States

IRMC Cancer Center

Indiana, Pennsylvania, 15701

United States

Jefferson Hospital

Jefferson Hills, Pennsylvania, 15025

United States

UPMC-Johnstown/John P. Murtha Regional Cancer Center

Johnstown, Pennsylvania, 15901

United States

Sechler Family Cancer Center

Lebanon, Pennsylvania, 17042

United States

Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837

United States

UPMC Cancer Center at UPMC McKeesport

McKeesport, Pennsylvania, 15132

United States

Yolanda G Barco Oncology Institute

Meadville, Pennsylvania, 16335

United States

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

Mechanicsburg, Pennsylvania, 17050

United States

Forbes Hospital

Monroeville, Pennsylvania, 15146

United States

UPMC Cancer Center - Monroeville

Monroeville, Pennsylvania, 15146

United States

UPMC Hillman Cancer Center in Coraopolis

Moon Township, Pennsylvania, 15108

United States

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107

United States

Temple University Hospital

Philadelphia, Pennsylvania, 19140

United States

Einstein Medical Center Philadelphia

Philadelphia, Pennsylvania, 19141

United States

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212

United States

UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, 15213

United States

UPMC-Saint Margaret

Pittsburgh, Pennsylvania, 15215

United States

West Penn Hospital

Pittsburgh, Pennsylvania, 15224

United States

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232

United States

UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232

United States

UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, 15237

United States

UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, Pennsylvania, 15243

United States

Geisinger Cancer Services-Pottsville

Pottsville, Pennsylvania, 17901

United States

Saint Luke's Hospital - Upper Bucks Campus

Quakertown, Pennsylvania, 18951

United States

Saint Luke's Hospital-Quakertown Campus

Quakertown, Pennsylvania, 18951

United States

UPMC Cancer Center at UPMC Northwest

Seneca, Pennsylvania, 16346

United States

Saint Luke's Hospital - Monroe Campus

Stroudsburg, Pennsylvania, 18360

United States

UPMC Cancer Center-Uniontown

Uniontown, Pennsylvania, 15401

United States

UPMC Uniontown Hospital Radiation Oncology

Uniontown, Pennsylvania, 15401

United States

UPMC Cancer Center-Washington

Washington, Pennsylvania, 15301

United States

UPMC Washington Hospital Radiation Oncology

Washington, Pennsylvania, 15301

United States

Chester County Hospital

West Chester, Pennsylvania, 19380

United States

Reading Hospital

West Reading, Pennsylvania, 19611

United States

Wexford Health and Wellness Pavilion

Wexford, Pennsylvania, 15090

United States

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711

United States

Divine Providence Hospital

Williamsport, Pennsylvania, 17754

United States

Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090

United States

WellSpan Health-York Cancer Center

York, Pennsylvania, 17403

United States

UPMC Memorial

York, Pennsylvania, 17408

United States

Rhode Island Hospital

Providence, Rhode Island, 02903

United States

Smilow Cancer Hospital Care Center - Westerly

Westerly, Rhode Island, 02891

United States

Saint Joseph's/Candler - Bluffton Campus

Bluffton, South Carolina, 29910

United States

Medical University of South Carolina

Charleston, South Carolina, 29425

United States

MUSC Health Florence Medical Center

Florence, South Carolina, 29505

United States

Saint Francis Hospital

Greenville, South Carolina, 29601

United States

Saint Francis Cancer Center

Greenville, South Carolina, 29607

United States

Self Regional Healthcare

Greenwood, South Carolina, 29646

United States

Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651

United States

The Radiation Oncology Center-Hilton Head/Bluffton

Hilton Head Island, South Carolina, 29926

United States

Carolina Regional Cancer Center

Myrtle Beach, South Carolina, 29577

United States

Beaufort Memorial/New River Cancer Center

Okatie, South Carolina, 29909

United States

Spartanburg Medical Center

Spartanburg, South Carolina, 29303

United States

Thompson Cancer Survival Center

Knoxville, Tennessee, 37916

United States

Thompson Oncology Group-Maryville

Maryville, Tennessee, 37804

United States

Thompson Oncology Group-Oak Ridge

Oak Ridge, Tennessee, 37830

United States

Houston Methodist San Jacinto Hospital

Baytown, Texas, 77521

United States

MD Anderson in The Woodlands

Conroe, Texas, 77384

United States

Houston Methodist Hospital

Houston, Texas, 77030

United States

M D Anderson Cancer Center

Houston, Texas, 77030

United States

Methodist Willowbrook Hospital

Houston, Texas, 77070

United States

MD Anderson West Houston

Houston, Texas, 77079

United States

Houston Methodist West Hospital

Houston, Texas, 77094

United States

MD Anderson League City

League City, Texas, 77573

United States

Texas Oncology-McKinney

McKinney, Texas, 75071

United States

Houston Methodist Saint John Hospital

Nassau Bay, Texas, 77058

United States

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229

United States

MD Anderson in Sugar Land

Sugar Land, Texas, 77478

United States

Houston Methodist Sugar Land Hospital

Sugar Land, Texas, 77479

United States

Houston Methodist The Woodlands Hospital

The Woodlands, Texas, 77385

United States

American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, 84003

United States

Farmington Health Center

Farmington, Utah, 84025

United States

Logan Regional Hospital

Logan, Utah, 84321

United States

Intermountain Medical Center

Murray, Utah, 84107

United States

McKay-Dee Hospital Center

Ogden, Utah, 84403

United States

Utah Valley Regional Medical Center

Provo, Utah, 84604

United States

Riverton Hospital

Riverton, Utah, 84065

United States

University of Utah Sugarhouse Health Center

Salt Lake City, Utah, 84106

United States

Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106

United States

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112

United States

LDS Hospital

Salt Lake City, Utah, 84143

United States

Saint George Regional Medical Center

St. George, Utah, 84770

United States

Central Vermont Medical Center/National Life Cancer Treatment

Berlin Corners, Vermont, 05602

United States

University of Vermont Medical Center

Burlington, Vermont, 05401

United States

Dartmouth Cancer Center - North

Saint Johnsbury, Vermont, 05819

United States

Inova Alexandria Hospital

Alexandria, Virginia, 22304

United States

Inova Schar Cancer Institute

Fairfax, Virginia, 22031

United States

Inova Fair Oaks Hospital

Fairfax, Virginia, 22033

United States

Bon Secours Saint Francis Medical Center

Midlothian, Virginia, 23114

United States

Bon Secours Cancer Institute at Reynolds Crossing

Richmond, Virginia, 23230

United States

VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298

United States

Oncology and Hematology Associates of Southwest Virginia

Roanoke, Virginia, 24014

United States

Virginia Mason Medical Center

Seattle, Washington, 98101

United States

Legacy Cancer Institute Medical Oncology and Day Treatment

Vancouver, Washington, 98684

United States

Legacy Salmon Creek Hospital

Vancouver, Washington, 98686

United States

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362

United States

West Virginia University Healthcare

Morgantown, West Virginia, 26506

United States

Wheeling Hospital/Schiffler Cancer Center

Wheeling, West Virginia, 26003

United States

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409

United States

ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911

United States

Ascension Saint Elizabeth Hospital

Appleton, Wisconsin, 54915

United States

Northwest Wisconsin Cancer Center

Ashland, Wisconsin, 54806

United States

Ascension Southeast Wisconsin Hospital - Elmbrook Campus

Brookfield, Wisconsin, 53045

United States

Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105

United States

Ascension Calumet Hospital

Chilton, Wisconsin, 53014

United States

HSHS Sacred Heart Hospital

Eau Claire, Wisconsin, 54701

United States

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701

United States

Ascension Saint Francis - Reiman Cancer Center

Franklin, Wisconsin, 53132

United States

Aurora Health Care Germantown Health Center

Germantown, Wisconsin, 53022

United States

Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024

United States

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301

United States

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303

United States

Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311

United States

University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038

United States

Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142

United States

Mayo Clinic Health System-Franciscan Healthcare

La Crosse, Wisconsin, 54601

United States

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, Wisconsin, 53718

United States

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792

United States

Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143

United States

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449

United States

Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051

United States

Ascension Columbia Saint Mary's Hospital Ozaukee

Mequon, Wisconsin, 53097

United States

Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209

United States

Ascension Columbia Saint Mary's Hospital - Milwaukee

Milwaukee, Wisconsin, 53211

United States

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215

United States

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

United States

Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233

United States

Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, 53295

United States

Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548

United States

Drexel Town Square Health Center

Oak Creek, Wisconsin, 53154

United States

Ascension Mercy Hospital

Oshkosh, Wisconsin, 54904

United States

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904

United States

Ascension All Saints Hospital

Racine, Wisconsin, 53405

United States

Aurora Cancer Care-Racine

Racine, Wisconsin, 53406

United States

Aspirus Cancer Care - James Beck Cancer Center

Rhinelander, Wisconsin, 54501

United States

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868

United States

Saint Vincent Hospital Cancer Center at Sheboygan

Sheboygan, Wisconsin, 53081

United States

Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081

United States

Aspirus Cancer Care - Stevens Point

Stevens Point, Wisconsin, 54481

United States

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482

United States

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235-1495

United States

Aurora Medical Center in Summit

Summit, Wisconsin, 53066

United States

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241

United States

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401

United States

Ascension Medical Group Southeast Wisconsin - Mayfair Road

Wauwatosa, Wisconsin, 53226

United States

Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226

United States

Aurora West Allis Medical Center

West Allis, Wisconsin, 53227

United States

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095

United States

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476

United States

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494

United States

Collaborators and Investigators

Sponsor: NRG Oncology

Paul L Nguyen, PRINCIPAL_INVESTIGATOR, NRG Oncology

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-01-21

Study Completion Date2033-12-31

Study Record Updates

Study Start Date2021-01-21

Study Completion Date2033-12-31

Terms related to this study

Additional Relevant MeSH Terms

Prostate Adenocarcinoma
Stage III Prostate Cancer AJCC v8
Stage IVA Prostate Cancer AJCC v8