RECRUITING

American Lung Association (ALA) Lung Health Cohort

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Conditions

Lung Diseaseslung healthenvironmental exposurechest CTspirometrybiomarkers

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The ALA-LHC is a longitudinal, multi-center cohort study that will enroll approximately 4,000 young adults between the ages of 25-35 who do not have severe lung disease. The overarching objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages.

Official Title

The American Lung Association (ALA) Lung Health Cohort

Quick Facts

Study Start:2021-10-29
Study Completion:2026-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04543461

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:25 Years to 35 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. 1. Severe asthma, which is defined as any of the following:
  2. 1. Current (i.e. at the time of the visit) GINA Step 4 or higher therapy (medium dose ICS/LABA or high dose ICS or add-on LAMA; Medium dose = \>250 fluticasone, propionate =100 fluticasone furoate, \>200 beclomethasone, \>400 budesonide, \>220 mometasone). We will accept low-dose ICS/LABA or medium dose ICS.
  3. 2. 3 or more unscheduled healthcare visits (provider/urgent care/ER) for asthma in the past 12 months OR
  4. 3. One asthma hospitalization in the past 12 months
  5. 2. History of any chronic lung disease other than asthma including but not limited to COPD, cystic fibrosis, pulmonary fibrosis, pulmonary hypertension
  6. 3. Current pregnancy
  7. 4. History of cancer other than non-melanoma skin cancer
  8. 5. Diagnosed cardiovascular diseases (i.e., congenital heart disease, coronary heart disease)
  9. 6. Inability to comply with study procedures, including
  10. 1. Inability or unwillingness to provide informed consent
  11. 2. Inability to perform study measurements
  12. 3. Inability to be contacted by phone (via calls and/or text messaging) or email
  13. 7. Any condition in the opinion of the physician that puts the participant at risk by participating in the study (e.g., serious respiratory illness requiring antibiotics or steroids or severe fever at the time of the study visit).
  14. 8. Institutionalization

Contacts and Locations

Study Contact

Elizabeth Sugar, PhD
CONTACT
443-287-3170
esugar2@jhu.edu
Curt Reynolds, MAS
CONTACT
410-614-2422
creynol1@jhu.edu

Principal Investigator

Ravi Kalhan, MD
PRINCIPAL_INVESTIGATOR
Northwestern University

Study Locations (Sites)

University Of Alabama
Birmingham, Alabama, 35294
United States
University of Arizona-Tuscon
Tucson, Arizona, 85724
United States
University of California, Los Angeles
Los Angeles, California, 90095
United States
University of California, San Francisco
San Francisco, California, 94143
United States
University of Colorado
Aurora, Colorado, 80045
United States
National Jewish Health
Denver, Colorado, 80206
United States
Nemours Children's Jacksonville
Jacksonville, Florida, 32207
United States
University of Florida, Jacksonville
Jacksonville, Florida, 32209
United States
University of Illinois at Chicago
Chicago, Illinois, 60608
United States
Northwestern University
Chicago, Illinois, 60611
United States
Rush Universtiy
Chicago, Illinois, 60612
United States
University of Chicago
Chicago, Illinois, 60637
United States
St. Vincent's Health System
Indianapolis, Indiana, 46260
United States
University of Iowa
Iowa City, Iowa, 52242
United States
University of Kansas
Kansas City, Kansas, 66103
United States
Johns Hopkins University
Baltimore, Maryland, 21218
United States
Brigham and Women's
Boston, Massachusetts, 02115
United States
University of Michigan
Ann Arbor, Michigan, 48109
United States
Presbyterian Brooklyn Methodist Hospital
Brooklyn, New York, 11215
United States
New York Medical College
Hawthorne, New York, 10532
United States
New York University
New York, New York, 10016
United States
Mt. Sinai, NYC
New York, New York, 10029
United States
Columbia University
New York, New York, 10032
United States
Cornell University
New York, New York, 10032
United States
University of Rochester
Rochester, New York, 14642
United States
University of North Carolina Hospital
Chapel Hill, North Carolina, 27517
United States
Duke University
Durham, North Carolina, 27710
United States
Wake Forest School of Medicine
Winston-Salem, North Carolina, 27104
United States
Ohio State University
Columbus, Ohio, 43210
United States
Temple University
Philadelphia, Pennsylvania, 19140
United States
University of Pittsburg-Emphysema/COPD Research Center
Pittsburgh, Pennsylvania, 15213
United States
Medical University of South Carolina
Charleston, South Carolina, 29425
United States
Vanderbilt University Medical Center
Nashville, Tennessee, 37235
United States
Baylor College of Medicine
Houston, Texas, 77030
United States
University of Vermont
Colchester, Vermont, 05446
United States
University of Washington
Seattle, Washington, 98108
United States
University of Wisconsin Madison
Madison, Wisconsin, 53792
United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

  • Ravi Kalhan, MD, PRINCIPAL_INVESTIGATOR, Northwestern University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-10-29
Study Completion Date2026-09

Study Record Updates

Study Start Date2021-10-29
Study Completion Date2026-09

Terms related to this study

Keywords Provided by Researchers

  • lung health
  • environmental exposure
  • chest CT
  • spirometry
  • biomarkers

Additional Relevant MeSH Terms

  • Lung Diseases