RECRUITING

Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer

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Conditions

Metastatic Bladder Urothelial CarcinomaMetastatic Urothelial CarcinomaRefractory Bladder Urothelial CarcinomaRefractory Urothelial CarcinomaStage IV Bladder Cancer AJCC v8

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This phase III trial compares the usual chemotherapy treatment to eribulin plus gemcitabine in treating patients with urothelial cancer that has spread from where it first started (primary site) to other places in the body (metastatic). Chemotherapy drugs, such as eribulin, gemcitabine, docetaxel, paclitaxel, and sacituzumab govitecan work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial aims to see whether adding eribulin to standard of care chemotherapy may work better in treating patients with metastatic urothelial cancer.

Official Title

A Phase III Randomized Trial of Eribulin (NSC #707389) With Gemcitabine Versus Standard of Care (Physician's Choice) for Treatment of Metastatic Urothelial Carcinoma Refractory to, or Ineligible for, Anti PD1/PDL1 Therapy

Quick Facts

Study Start:2021-06-28
Study Completion:2030-08-15
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04579224

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Participant must have predominant histologically or cytologically proven urothelial carcinoma in a metastatic site
  2. * Participant must have evidence of metastatic urothelial carcinoma based on CT or MRI within 28 days prior to registration
  3. * Participant must have had progression of disease following prior therapy at the discretion of the treating investigator
  4. * Participants must not require immediate central nervous system (CNS)-specific treatment, in the opinion of the treating investigator if they have active brain metastases (defined as new or progressive brain metastases) or leptomeningeal disease
  5. * Participant must have had prior systemic therapy in metastatic setting that:
  6. * Included enfortumab vedotin
  7. * Included a PD1/PDL1 antibody
  8. * NOTE: Under the discretion of the treating physician, participants who are not candidates for PD1/PDL1 antibody systemic therapy are allowed
  9. * Any systemic therapy provided in adjuvant, neoadjuvant, or chemoradiation settings for urothelial carcinoma can be considered to be in metastatic setting, if the last day of treatment was within 12 months prior to the diagnosis of metastatic disease
  10. * Participant must have completed any planned surgery or radiation therapy prior to registration
  11. * Participant must not have unresolved toxicities from prior surgeries or radiation therapy \> grade 1 at the time of registration
  12. * Participant must be ≥ 18 years of age
  13. * Participant must have Zubrod performance status 0-2
  14. * Participant must have history and physical examination within 28 days prior to registration
  15. * Participant must have complete blood count (CBC), complete metabolic panel including liver function tests, and lactate dehydrogenase (LDH) obtained within 28 days prior to registration
  16. * Participant must have adequate kidney function as evidenced by measured or calculated creatinine clearance \>= 20 mL/min within 28 days prior to registration
  17. * Participant must have adequate hepatic function documented by either aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =\< 3 x institutional upper limit of normal (IULN) within 28 days prior to registration. If both AST and ALT are performed, both must be =\< 3 x IULN. For participants with liver metastases, AST or ALT must be =\< 5 x IULN
  18. * Participant must be on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 6 months prior to registration if they are known to have human immunodeficiency virus (HIV)-infection
  19. * Participants must have undetectable hepatitis B virus (HBV) viral load within 28 days prior to registration if participant has known chronic hepatitis B virus (HBV) infection
  20. * Participants with a known history of hepatitis C virus (HCV) infection must have an undetectable HCV viral load within 28 days prior to registration
  21. * Participants may have a prior or concurrent malignancy provided the natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen per the opinion of the treating investigator
  22. * Participants must not be planning to take strong or moderate CYP3A or CYP2C8 inhibitors or inducers if randomized to Arm 1 and standard of care (SOC) regimen chosen is paclitaxel or docetaxel. Participants receiving strong or moderate CYP3A- or CYP2C8 inducers must discontinue use at least 2 weeks prior to randomization
  23. * Participant must not have a known history of corrected QT (QTc) prolongation
  24. * Participants must not be pregnant or nursing due to the risk of harm to a fetus or nursing infant. Women and men of reproductive potential must have agreed to use an effective contraceptive method for the course of the study and 6 months (females) or 3.5 months (males) after the last dose. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
  25. * Participants must be offered the opportunity to participate in specimen banking as outlined
  26. * Participants must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
  27. * As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Principal Investigator

Sarmad Sadeghi
PRINCIPAL_INVESTIGATOR
SWOG Cancer Research Network

Study Locations (Sites)

Kingman Regional Medical Center
Kingman, Arizona, 86401
United States
Cancer Center at Saint Joseph's
Phoenix, Arizona, 85004
United States
Mercy Hospital Fort Smith
Fort Smith, Arkansas, 72903
United States
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs, Arkansas, 71913
United States
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, 93420
United States
PCR Oncology
Arroyo Grande, California, 93420
United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, 92612
United States
Keck Medicine of USC Koreatown
Los Angeles, California, 90020
United States
Los Angeles General Medical Center
Los Angeles, California, 90033
United States
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033
United States
Fremont - Rideout Cancer Center
Marysville, California, 95901
United States
USC Norris Oncology/Hematology-Newport Beach
Newport Beach, California, 92663
United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868
United States
Keck Medical Center of USC Pasadena
Pasadena, California, 91105
United States
University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817
United States
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California, 93401
United States
Mission Hope Medical Oncology - Santa Maria
Santa Maria, California, 93444
United States
UCHealth University of Colorado Hospital
Aurora, Colorado, 80045
United States
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
United States
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, 80907
United States
Porter Adventist Hospital
Denver, Colorado, 80210
United States
Mercy Medical Center
Durango, Colorado, 81301
United States
Southwest Oncology PC
Durango, Colorado, 81301
United States
Poudre Valley Hospital
Fort Collins, Colorado, 80524
United States
Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado, 80528
United States
UCHealth Greeley Hospital
Greeley, Colorado, 80631
United States
UCHealth Highlands Ranch Hospital
Highlands Ranch, Colorado, 80129
United States
Saint Anthony Hospital
Lakewood, Colorado, 80228
United States
Littleton Adventist Hospital
Littleton, Colorado, 80122
United States
Longmont United Hospital
Longmont, Colorado, 80501
United States
Rocky Mountain Cancer Centers-Longmont
Longmont, Colorado, 80501
United States
Medical Center of the Rockies
Loveland, Colorado, 80538
United States
Parker Adventist Hospital
Parker, Colorado, 80138
United States
Saint Mary Corwin Medical Center
Pueblo, Colorado, 81004
United States
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut, 06418
United States
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut, 06824
United States
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut, 06033
United States
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut, 06830
United States
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, 06437
United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, 06105
United States
Yale University
New Haven, Connecticut, 06520
United States
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut, 06473
United States
Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut, 06902
United States
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut, 06790
United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611
United States
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut, 06708
United States
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385
United States
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura, Florida, 33180
United States
Holy Cross Hospital
Fort Lauderdale, Florida, 33308
United States
Mount Sinai Medical Center
Miami Beach, Florida, 33140
United States
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605
United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, 83814
United States
Walter Knox Memorial Hospital
Emmett, Idaho, 83617
United States
Idaho Urologic Institute-Meridian
Meridian, Idaho, 83642
United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, 83687
United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854
United States
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, 83864
United States
OSF Saint Anthony's Health Center
Alton, Illinois, 62002
United States
Rush - Copley Medical Center
Aurora, Illinois, 60504
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
United States
Illinois CancerCare-Canton
Canton, Illinois, 61520
United States
Memorial Hospital of Carbondale
Carbondale, Illinois, 62902
United States
SIH Cancer Institute
Carterville, Illinois, 62918
United States
Illinois CancerCare-Carthage
Carthage, Illinois, 62321
United States
Centralia Oncology Clinic
Centralia, Illinois, 62801
United States
Northwestern University
Chicago, Illinois, 60611
United States
Carle at The Riverfront
Danville, Illinois, 61832
United States
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
United States
Decatur Memorial Hospital
Decatur, Illinois, 62526
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, 60115
United States
Illinois CancerCare-Dixon
Dixon, Illinois, 61021
United States
Carle Physician Group-Effingham
Effingham, Illinois, 62401
United States
Crossroads Cancer Center
Effingham, Illinois, 62401
United States
Illinois CancerCare-Eureka
Eureka, Illinois, 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
United States
Western Illinois Cancer Treatment Center
Galesburg, Illinois, 61401
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, 60045
United States
Illinois CancerCare-Macomb
Macomb, Illinois, 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
United States
Loyola University Medical Center
Maywood, Illinois, 60153
United States
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Melrose Park, Illinois, 60160
United States
Good Samaritan Regional Health Center
Mount Vernon, Illinois, 62864
United States
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
United States
Illinois CancerCare-Pekin
Pekin, Illinois, 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
United States
Illinois CancerCare-Peru
Peru, Illinois, 61354
United States
Valley Radiation Oncology
Peru, Illinois, 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois, 61356
United States
UW Health Carbone Cancer Center Rockford
Rockford, Illinois, 61114
United States
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
United States
Springfield Clinic
Springfield, Illinois, 62702
United States
Springfield Memorial Hospital
Springfield, Illinois, 62781
United States
Carle Cancer Center
Urbana, Illinois, 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555
United States
Illinois CancerCare - Washington
Washington, Illinois, 61571
United States
Rush-Copley Healthcare Center
Yorkville, Illinois, 60560
United States
Reid Health
Richmond, Indiana, 47374
United States
Mary Greeley Medical Center
Ames, Iowa, 50010
United States
McFarland Clinic - Ames
Ames, Iowa, 50010
United States
Mission Cancer and Blood - Ankeny
Ankeny, Iowa, 50023
United States
McFarland Clinic - Boone
Boone, Iowa, 50036
United States
Saint Anthony Regional Hospital
Carroll, Iowa, 51401
United States
Mercy Hospital
Cedar Rapids, Iowa, 52403
United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, 52403
United States
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325
United States
Mission Cancer and Blood - West Des Moines
Clive, Iowa, 50325
United States
Alegent Health Mercy Hospital
Council Bluffs, Iowa, 51503
United States
Greater Regional Medical Center
Creston, Iowa, 50801
United States
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
United States
Mission Cancer and Blood - Des Moines
Des Moines, Iowa, 50309
United States
Broadlawns Medical Center
Des Moines, Iowa, 50314
United States
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
United States
Mission Cancer and Blood - Laurel
Des Moines, Iowa, 50314
United States
Iowa Lutheran Hospital
Des Moines, Iowa, 50316
United States
McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa, 50501
United States
Trinity Regional Medical Center
Fort Dodge, Iowa, 50501
United States
McFarland Clinic - Jefferson
Jefferson, Iowa, 50129
United States
McFarland Clinic - Marshalltown
Marshalltown, Iowa, 50158
United States
Methodist West Hospital
West Des Moines, Iowa, 50266-7700
United States
Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266
United States
Central Care Cancer Center - Garden City
Garden City, Kansas, 67846
United States
Central Care Cancer Center - Great Bend
Great Bend, Kansas, 67530
United States
HaysMed
Hays, Kansas, 67601
United States
University of Kansas Cancer Center
Kansas City, Kansas, 66160
United States
Lawrence Memorial Hospital
Lawrence, Kansas, 66044
United States
The University of Kansas Cancer Center - Olathe
Olathe, Kansas, 66061
United States
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, 66210
United States
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas, 66211
United States
Salina Regional Health Center
Salina, Kansas, 67401
United States
University of Kansas Health System Saint Francis Campus
Topeka, Kansas, 66606
United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205
United States
Flaget Memorial Hospital
Bardstown, Kentucky, 40004
United States
Commonwealth Cancer Center-Corbin
Corbin, Kentucky, 40701
United States
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky, 40504
United States
Saint Joseph Hospital East
Lexington, Kentucky, 40509
United States
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536
United States
Saint Joseph London
London, Kentucky, 40741
United States
Jewish Hospital
Louisville, Kentucky, 40202
United States
Saints Mary and Elizabeth Hospital
Louisville, Kentucky, 40215
United States
UofL Health Medical Center Northeast
Louisville, Kentucky, 40245
United States
Jewish Hospital Medical Center South
Shepherdsville, Kentucky, 40165
United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106
United States
Bronson Battle Creek
Battle Creek, Michigan, 49017
United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, 48114
United States
Trinity Health Medical Center - Brighton
Brighton, Michigan, 48114
United States
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan, 48183
United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan, 48188
United States
Trinity Health Medical Center - Canton
Canton, Michigan, 48188
United States
Caro Cancer Center
Caro, Michigan, 48723
United States
Chelsea Hospital
Chelsea, Michigan, 48118
United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, 48118
United States
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan, 48346
United States
Newland Medical Associates-Clarkston
Clarkston, Michigan, 48346
United States
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, 48038
United States
Henry Ford Medical Center-Fairlane
Dearborn, Michigan, 48126
United States
Henry Ford Hospital
Detroit, Michigan, 48202
United States
Henry Ford Health Saint John Hospital
Detroit, Michigan, 48236
United States
Henry Ford River District Hospital
East China Township, Michigan, 48054
United States
OSF Saint Francis Hospital and Medical Group
Escanaba, Michigan, 49829
United States
Cancer Hematology Centers - Flint
Flint, Michigan, 48503
United States
Genesee Hematology Oncology PC
Flint, Michigan, 48503
United States
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
United States
Hurley Medical Center
Flint, Michigan, 48503
United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, 49503
United States
Henry Ford Saint John Hospital - Academic
Grosse Pointe Woods, Michigan, 48236
United States
Henry Ford Saint John Hospital - Breast
Grosse Pointe Woods, Michigan, 48236
United States
Henry Ford Saint John Hospital - Van Elslander
Grosse Pointe Woods, Michigan, 48236
United States
Allegiance Health
Jackson, Michigan, 49201
United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
United States
Ascension Borgess Cancer Center
Kalamazoo, Michigan, 49009
United States
University of Michigan Health - Sparrow Lansing
Lansing, Michigan, 48912
United States
Hope Cancer Clinic
Livonia, Michigan, 48154
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154
United States
Henry Ford Saint John Hospital - Macomb Medical
Macomb, Michigan, 48044
United States
Henry Ford Warren Hospital - Breast Macomb
Macomb, Michigan, 48044
United States
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette, Michigan, 48453
United States
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan, 49120
United States
Henry Ford Medical Center-Columbus
Novi, Michigan, 48377
United States
Hope Cancer Center
Pontiac, Michigan, 48341
United States
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan, 48341
United States
Newland Medical Associates-Pontiac
Pontiac, Michigan, 48341
United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, 48341
United States
MyMichigan Medical Center Saginaw
Saginaw, Michigan, 48601
United States
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan, 48604
United States
Henry Ford Macomb Health Center - Shelby Township
Shelby, Michigan, 48315
United States
Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, Michigan, 48312
United States
MyMichigan Medical Center Tawas
Tawas City, Michigan, 48764
United States
Munson Medical Center
Traverse City, Michigan, 49684
United States
Advanced Breast Care Center PLLC
Warren, Michigan, 48088
United States
Henry Ford Health Warren Hospital
Warren, Michigan, 48093
United States
Henry Ford Madison Heights Hospital - Breast
Warren, Michigan, 48093
United States
Henry Ford Warren Hospital - GLCMS
Warren, Michigan, 48093
United States
Macomb Hematology Oncology PC
Warren, Michigan, 48093
United States
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, 48322
United States
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, Michigan, 48661
United States
University of Michigan Health - West
Wyoming, Michigan, 49519
United States
Huron Gastroenterology PC
Ypsilanti, Michigan, 48106
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, 48197
United States
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
United States
Fairview Ridges Hospital
Burnsville, Minnesota, 55337
United States
Minnesota Oncology - Burnsville
Burnsville, Minnesota, 55337
United States
Cambridge Medical Center
Cambridge, Minnesota, 55008
United States
Mercy Hospital
Coon Rapids, Minnesota, 55433
United States
Fairview Southdale Hospital
Edina, Minnesota, 55435
United States
Unity Hospital
Fridley, Minnesota, 55432
United States
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, 55369
United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
United States
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
United States
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
United States
Health Partners Inc
Minneapolis, Minnesota, 55454
United States
Monticello Cancer Center
Monticello, Minnesota, 55362
United States
New Ulm Medical Center
New Ulm, Minnesota, 56073
United States
Fairview Northland Medical Center
Princeton, Minnesota, 55371
United States
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
United States
Regions Hospital
Saint Paul, Minnesota, 55101
United States
United Hospital
Saint Paul, Minnesota, 55102
United States
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
United States
Lakeview Hospital
Stillwater, Minnesota, 55082
United States
Sanford Thief River Falls Medical Center
Thief River Falls, Minnesota, 56701
United States
Ridgeview Medical Center
Waconia, Minnesota, 55387
United States
Rice Memorial Hospital
Willmar, Minnesota, 56201
United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
United States
Sanford Cancer Center Worthington
Worthington, Minnesota, 56187
United States
Fairview Lakes Medical Center
Wyoming, Minnesota, 55092
United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216
United States
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri, 63011
United States
Central Care Cancer Center - Bolivar
Bolivar, Missouri, 65613
United States
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
United States
Southeast Cancer Center
Cape Girardeau, Missouri, 63703
United States
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, Missouri, 65212
United States
Parkland Health Center - Farmington
Farmington, Missouri, 63640
United States
MU Health Care Goldschmidt Cancer Center
Jefferson City, Missouri, 65109
United States
Freeman Health System
Joplin, Missouri, 64804
United States
Mercy Hospital Joplin
Joplin, Missouri, 64804
United States
University Health Truman Medical Center
Kansas City, Missouri, 64108
United States
University of Kansas Cancer Center - North
Kansas City, Missouri, 64154
United States
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri, 64064
United States
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City, Missouri, 64116
United States
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri, 65401
United States
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, 65401
United States
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506
United States
Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri, 63109
United States
Mercy Hospital South
Saint Louis, Missouri, 63128
United States
Missouri Baptist Medical Center
Saint Louis, Missouri, 63131
United States
Mercy Hospital Saint Louis
Saint Louis, Missouri, 63141
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
United States
Mercy Hospital Springfield
Springfield, Missouri, 65804
United States
CoxHealth South Hospital
Springfield, Missouri, 65807
United States
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, 63127
United States
Mercy Hospital Washington
Washington, Missouri, 63090
United States
Community Hospital of Anaconda
Anaconda, Montana, 59711
United States
Billings Clinic Cancer Center
Billings, Montana, 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana, 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana, 59405
United States
Great Falls Clinic
Great Falls, Montana, 59405
United States
Logan Health Medical Center
Kalispell, Montana, 59901
United States
Community Medical Center
Missoula, Montana, 59804
United States
Nebraska Cancer Specialists/Oncology Hematology West PC
Grand Island, Nebraska, 68803
United States
CHI Health Good Samaritan
Kearney, Nebraska, 68847
United States
Saint Elizabeth Regional Medical Center
Lincoln, Nebraska, 68510
United States
Alegent Health Immanuel Medical Center
Omaha, Nebraska, 68122
United States
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
United States
Alegent Health Lakeside Hospital
Omaha, Nebraska, 68130
United States
Creighton University Medical Center
Omaha, Nebraska, 68131
United States
Midlands Community Hospital
Papillion, Nebraska, 68046
United States
Carson Tahoe Regional Medical Center
Carson City, Nevada, 89703
United States
Cancer and Blood Specialists-Henderson
Henderson, Nevada, 89052
United States
Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada, 89052
United States
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada, 89052
United States
Las Vegas Cancer Center-Henderson
Henderson, Nevada, 89052
United States
OptumCare Cancer Care at Seven Hills
Henderson, Nevada, 89052
United States
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada, 89074
United States
GenesisCare USA - Henderson
Henderson, Nevada, 89074
United States
Las Vegas Urology - Green Valley
Henderson, Nevada, 89074
United States
Las Vegas Urology - Pebble
Henderson, Nevada, 89074
United States
Urology Specialists of Nevada - Green Valley
Henderson, Nevada, 89074
United States
Las Vegas Urology - Pecos
Las Vegas, Nevada, 89074
United States
Desert West Surgery
Las Vegas, Nevada, 89102
United States
OptumCare Cancer Care at Charleston
Las Vegas, Nevada, 89102
United States
University Medical Center of Southern Nevada
Las Vegas, Nevada, 89102
United States
Hope Cancer Care of Nevada
Las Vegas, Nevada, 89103
United States
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada, 89106
United States
Urology Specialists of Nevada - Central
Las Vegas, Nevada, 89106
United States
GenesisCare USA - Las Vegas
Las Vegas, Nevada, 89109
United States
Sunrise Hospital and Medical Center
Las Vegas, Nevada, 89109
United States
Las Vegas Prostate Cancer Center
Las Vegas, Nevada, 89113
United States
Las Vegas Urology - Sunset
Las Vegas, Nevada, 89113
United States
Urology Specialists of Nevada - Southwest
Las Vegas, Nevada, 89113
United States
Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada, 89119
United States
Ann M Wierman MD LTD
Las Vegas, Nevada, 89128
United States
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada, 89128
United States
GenesisCare USA - Vegas Tenaya
Las Vegas, Nevada, 89128
United States
Las Vegas Urology - Cathedral Rock
Las Vegas, Nevada, 89128
United States
Las Vegas Urology - Smoke Ranch
Las Vegas, Nevada, 89128
United States
OptumCare Cancer Care at MountainView
Las Vegas, Nevada, 89128
United States
Urology Specialists of Nevada - Northwest
Las Vegas, Nevada, 89128
United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, 89135
United States
Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas, Nevada, 89144
United States
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada, 89144
United States
Summerlin Hospital Medical Center
Las Vegas, Nevada, 89144
United States
Las Vegas Cancer Center-Medical Center
Las Vegas, Nevada, 89148-2405
United States
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89148
United States
GenesisCare USA - Fort Apache
Las Vegas, Nevada, 89148
United States
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada, 89148
United States
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada, 89169
United States
University Cancer Center
Las Vegas, Nevada, 89169
United States
Hope Cancer Care of Nevada-Pahrump
Pahrump, Nevada, 89048
United States
Renown Regional Medical Center
Reno, Nevada, 89502
United States
Saint Mary's Regional Medical Center
Reno, Nevada, 89503
United States
Radiation Oncology Associates
Reno, Nevada, 89509
United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
United States
Roswell Park Cancer Institute
Buffalo, New York, 14263
United States
Glens Falls Hospital
Glens Falls, New York, 12801
United States
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina, 28328
United States
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina, 27534
United States
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina, 28546
United States
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501
United States
Sanford South University Medical Center
Fargo, North Dakota, 58103
United States
Southpointe-Sanford Medical Center Fargo
Fargo, North Dakota, 58103
United States
Sanford Medical Center Fargo
Fargo, North Dakota, 58104
United States
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
United States
UH Seidman Cancer Center at UH Avon Health Center
Avon, Ohio, 44011
United States
UHHS-Chagrin Highlands Medical Center
Beachwood, Ohio, 44122
United States
Indu and Raj Soin Medical Center
Beavercreek, Ohio, 45431
United States
Saint Elizabeth Boardman Hospital
Boardman, Ohio, 44512
United States
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio, 45459
United States
Miami Valley Hospital South
Centerville, Ohio, 45459
United States
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, 45220
United States
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio, 45236
United States
Bethesda North Hospital
Cincinnati, Ohio, 45242
United States
TriHealth Cancer Institute-Westside
Cincinnati, Ohio, 45247
United States
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio, 45255
United States
Case Western Reserve University
Cleveland, Ohio, 44106
United States
Miami Valley Hospital
Dayton, Ohio, 45409
United States
Dayton Physician LLC - Englewood
Dayton, Ohio, 45415
United States
Miami Valley Hospital North
Dayton, Ohio, 45415
United States
Armes Family Cancer Center
Findlay, Ohio, 45840
United States
Blanchard Valley Hospital
Findlay, Ohio, 45840
United States
Orion Cancer Care
Findlay, Ohio, 45840
United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, 45005-1066
United States
Dayton Physicians LLC-Atrium
Franklin, Ohio, 45005
United States
Dayton Physicians LLC-Wayne
Greenville, Ohio, 45331
United States
Wayne Hospital
Greenville, Ohio, 45331
United States
Greater Dayton Cancer Center
Kettering, Ohio, 45409
United States
Kettering Medical Center
Kettering, Ohio, 45429
United States
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor, Ohio, 44060
United States
Springfield Regional Cancer Center
Springfield, Ohio, 45504
United States
Springfield Regional Medical Center
Springfield, Ohio, 45504
United States
Dayton Physicians LLC - Troy
Troy, Ohio, 45373
United States
Upper Valley Medical Center
Troy, Ohio, 45373
United States
Saint Joseph Warren Hospital
Warren, Ohio, 44484
United States
Wright-Patterson Medical Center
Wright-Patterson Air Force Base, Ohio, 45433
United States
Saint Elizabeth Youngstown Hospital
Youngstown, Ohio, 44501
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
United States
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120
United States
Saint Alphonsus Cancer Care Center-Baker City
Baker City, Oregon, 97814
United States
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon, 97914
United States
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
United States
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania, 18017
United States
Pocono Medical Center
East Stroudsburg, Pennsylvania, 18301
United States
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania, 18201
United States
Smilow Cancer Hospital Care Center - Westerly
Westerly, Rhode Island, 02891
United States
Medical University of South Carolina
Charleston, South Carolina, 29425
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
United States
Bristol Regional Medical Center
Bristol, Tennessee, 37620
United States
The West Clinic - Wolf River
Germantown, Tennessee, 38138
United States
Ballad Health Cancer Care - Kingsport
Kingsport, Tennessee, 37660
United States
Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee, 37660
United States
Saint Joseph Regional Cancer Center
Bryan, Texas, 77802
United States
Parkland Memorial Hospital
Dallas, Texas, 75235
United States
UT Southwestern Simmons Cancer Center - RedBird
Dallas, Texas, 75237
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas, 76104
United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030
United States
Ben Taub General Hospital
Houston, Texas, 77030
United States
Michael E DeBakey VA Medical Center
Houston, Texas, 77030
United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas, 75080
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112
United States
Ballad Health Cancer Care - Bristol
Bristol, Virginia, 24201
United States
Ballad Health Cancer Care - Norton
Norton, Virginia, 24273
United States
Overlake Medical Center
Bellevue, Washington, 98004
United States
Highline Medical Center-Main Campus
Burien, Washington, 98166
United States
Saint Elizabeth Hospital
Enumclaw, Washington, 98022
United States
Saint Francis Hospital
Federal Way, Washington, 98003
United States
Saint Clare Hospital
Lakewood, Washington, 98499
United States
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo, Washington, 98370
United States
Valley Medical Center
Renton, Washington, 98055
United States
Saint Michael Cancer Center
Silverdale, Washington, 98383
United States
Franciscan Research Center-Northwest Medical Plaza
Tacoma, Washington, 98405
United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, 98902
United States
Edwards Comprehensive Cancer Center
Huntington, West Virginia, 25701
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301
United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, 54303
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
United States
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
United States
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin, 54154
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
United States
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin, 53081
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482
United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235-1495
United States
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476
United States
Billings Clinic-Cody
Cody, Wyoming, 82414
United States
Welch Cancer Center
Sheridan, Wyoming, 82801
United States

Collaborators and Investigators

Sponsor: National Cancer Institute (NCI)

  • Sarmad Sadeghi, PRINCIPAL_INVESTIGATOR, SWOG Cancer Research Network

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-06-28
Study Completion Date2030-08-15

Study Record Updates

Study Start Date2021-06-28
Study Completion Date2030-08-15

Terms related to this study

Additional Relevant MeSH Terms

  • Metastatic Bladder Urothelial Carcinoma
  • Metastatic Urothelial Carcinoma
  • Refractory Bladder Urothelial Carcinoma
  • Refractory Urothelial Carcinoma
  • Stage IV Bladder Cancer AJCC v8