RECRUITING

VEGF and sFlt-1 Levels in the Pathogenesis and Severity of COVID-19 Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

To assess blood levels of vasoactive mediators that may regulate pulmonary endothelial permeability and contribute to multi-organ injury in patients with COVID-19 disease and to correlate the levels of these mediators with disease outcomes such as ICU admission, length of ventilatory support, respiratory failure, kidney failure, heart failure, and death.

Official Title

COVID-19 RELATED SUBMISSION: VEGF and sFlt-1 Levels in the Pathogenesis and Severity of COVID-19 Disease

Quick Facts

Study Start:2020-05-22
Study Completion:2025-01-20
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04587323

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Positive test for COVID-19 (SARS-CoV-2 infection)
  2. * \>=18 years
  3. * Blood (plasma) specimen(s) available in the CCTS biorepository
  1. * \<18 years
  2. * Lack of blood specimen

Contacts and Locations

Study Contact

Dylan Addis, MD
CONTACT
919-812-5107
dylanaddis@uabmc.edu
Shanna H Graves
CONTACT
205-975-2845
shannagraves@uabmc.edu

Principal Investigator

Dylan Addis, MD
PRINCIPAL_INVESTIGATOR
University of Alabama at Birmingham

Study Locations (Sites)

University of Alabama at Birmingham
Birmingham, Alabama, 35294
United States

Collaborators and Investigators

Sponsor: University of Alabama at Birmingham

  • Dylan Addis, MD, PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-05-22
Study Completion Date2025-01-20

Study Record Updates

Study Start Date2020-05-22
Study Completion Date2025-01-20

Terms related to this study

Keywords Provided by Researchers

  • COVID-19
  • SARS-CoV-2 viral infection
  • VEGF and sFlt-1 levels

Additional Relevant MeSH Terms

  • COVID-19 Disease