RECRUITING

Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial

Description

Open label, multi-center, pre-hospital randomized trial utilizing 10 level-1 trauma centers designed to determine the efficacy and safety of low titer whole blood resuscitation as compared to standard of care resuscitation in patients at risk of hemorrhagic shock and to appropriately characterize the hemostatic competency of whole blood relative to its age.

Study Overview

Study Details

Study overview

Open label, multi-center, pre-hospital randomized trial utilizing 10 level-1 trauma centers designed to determine the efficacy and safety of low titer whole blood resuscitation as compared to standard of care resuscitation in patients at risk of hemorrhagic shock and to appropriately characterize the hemostatic competency of whole blood relative to its age.

Type O Whole Blood and Assessment of Age During Prehospital Resuscitation (TOWAR) Trial

Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial

Condition
Hemorrhagic Shock
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35294

Louisville

University of Louisville, Louisville, Kentucky, United States, 40292

Jackson

University of Mississippi Medical Center (UMMC), Jackson, Mississippi, United States, 39216

Cincinnati

University of Cincinatti, Cincinnati, Ohio, United States, 45267

Cleveland

Metrohealth Systems, Cleveland, Ohio, United States, 44109

Pittsburgh

University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 15213

Knoxville

University of Tennessee Medical Center, Knoxville, Tennessee, United States, 37920

Nashville

Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37232

Houston

University of Texas Health Science Center at Houston, Houston, Texas, United States, 77030

Seattle

University of Washington, Seattle, Washington, United States, 98104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1.) Injured patients at risk of hemorrhagic shock being transported from scene or referral hospital to a participating TOWAR trial site that meet requirements for initiation of blood or blood component transfusion
  • 1. Wearing NO TOWAR opt-out bracelet
  • 2. Age \> 90 or \< 18 years of age
  • 3. Isolated fall from standing injury mechanism
  • 4. Known prisoner or known pregnancy
  • 5. Traumatic arrest with \> 5 minutes of CPR without return of vital signs
  • 6. Brain matter exposed or penetrating brain injury (GSW)
  • 7. Isolated drowning or hanging victims
  • 8. Objection to study voiced by subject or family member at the scene
  • 9. Inability to obtain IV or intraosseous access
  • 10. Isolated burns without evidence of traumatic injury

Ages Eligible for Study

18 Years to 89 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Jason Sperry,

Jason L Sperry, MD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

2025-09