RECRUITING

Genetic Studies of Strabismus, Nystagmus, and Associated Disorders

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Strabismus (misalignment of the eyes) often runs in families. In this study, the investigators are looking for genetic variants associated with strabismus and nystagmus. Three types of subects will be enrolled: (1) Families with at least 3 members with strabismus, (2) individuals with infantile esotropia and their parents and siblings, and (3) individuals with infantile nystagmus and their parents. Whole exome and/or whole genome sequencing will be used to identify genetic variants shared by family members with strabismus and to identify genetic causes of nystagmus.

Official Title

Genetic Studies of Strabismus, Nystagmus, and Associated Disorders

Quick Facts

Study Start:2021-09-03
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04770519

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. * paralytic strabismus in affected family members

Contacts and Locations

Study Contact

Tapiwa Muvavarirwa, BA
CONTACT
857-292-3768
research.whitman@childrens.harvard.edu

Principal Investigator

Mary Whitman, MD/PhD
PRINCIPAL_INVESTIGATOR
Assistant Professor

Study Locations (Sites)

Boston Children's Hospital
Boston, Massachusetts, 02115
United States

Collaborators and Investigators

Sponsor: Boston Children's Hospital

  • Mary Whitman, MD/PhD, PRINCIPAL_INVESTIGATOR, Assistant Professor

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-09-03
Study Completion Date2026-12

Study Record Updates

Study Start Date2021-09-03
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • strabismus
  • esotropia
  • exotropia
  • nystagmus

Additional Relevant MeSH Terms

  • Strabismus
  • Nystagmus, Congenital