RECRUITING

Cognition and the Immunology of Postoperative Outcomes

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This research will test the hypothesis that immune system disequilibrium / dysfunction explains why preoperative cognitive impairment is a strong predictor of postoperative morbidity in older surgical patients. The investigators propose that cognitive impairment influences surgical morbidity because of underlying immune disequilibrium / dysfunction (risk marker) and that this shapes the immune response to surgery and defines immunological hallmarks of postoperative morbidity (disease marker). The overarching goal of this application therefore is to define and better understand the clinical immunology underlying the relationship between cognition and geriatric surgical morbidity.

Official Title

Cognition and the Immunology of Postoperative Outcomes

Quick Facts

Study Start:2019-09-06
Study Completion:2025-07-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04792983

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients ≥ 65 years of age
  2. * American Society of Anesthesiologists (ASA) physical status of I-III
  3. * Scheduled for elective spine surgery.
  1. * History of stroke (not including transient ischemic attacks, or TIAs)
  2. * History of brain tumor
  3. * History of autoimmune disorders
  4. * Medications likely to significantly impact inflammation (e.g. steroids)
  5. * Current infection
  6. * Uncorrected vision or hearing impairment
  7. * limited use of the dominant hand (limited ability to draw)
  8. * inability to speak, read, or understand English.

Contacts and Locations

Study Contact

Gregory J Crosby, MD
CONTACT
617-732-7398
gcrosby@bwh.harvard.edu
Erin J Kim, BA
CONTACT
7034088957
ekim56@bwh.harvard.edu

Principal Investigator

Gregory J Crosby, MD
PRINCIPAL_INVESTIGATOR
Brigham & Women's Hospital; Harvard Medical School

Study Locations (Sites)

Brigham & Women's Hospital
Boston, Massachusetts, 02115
United States

Collaborators and Investigators

Sponsor: Brigham and Women's Hospital

  • Gregory J Crosby, MD, PRINCIPAL_INVESTIGATOR, Brigham & Women's Hospital; Harvard Medical School

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-09-06
Study Completion Date2025-07-31

Study Record Updates

Study Start Date2019-09-06
Study Completion Date2025-07-31

Terms related to this study

Keywords Provided by Researchers

  • postoperative health outcomes
  • older surgical patients
  • delirium
  • spine surgery

Additional Relevant MeSH Terms

  • Cognitive Impairment
  • Frail Elderly Syndrome
  • Delirium
  • Surgery