SUSPENDED

Surgical Resection of Latent Brain Tumors Prior to Recurrence

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Conditions

Brain Neoplasm

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This clinical trial evaluates the side effects and possible benefits of operating on brain tumors prior to the tumor coming back (recurrence). Understanding when surgery is most useful to patients with brain tumors is important. Some patients may undergo chemotherapy or radiation but still have visible tumor remaining after treatment. The purpose of this research is to compare outcomes of those who have surgery after chemotherapy or radiation, but prior to tumor recurrence, to those who have surgery at a different time, or no surgery at all.

Official Title

Surgical Resection of Latent Brain Tumors Prior to Recurrence

Quick Facts

Study Start:2021-05-06
Study Completion:2028-03-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:SUSPENDED

Study ID

NCT04810871

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age \>= 18 years
  2. * Histological or cytological confirmation of brain tumor and/or suspected brain tumor based on clinical and radiologic findings
  3. * Prior chemotherapy and/or radiation treatment directed to the known/suspected tumor
  4. * Radiographic evidence of residual or previously unresected tumor
  5. * Willingness to undergo surgery and sign informed consent
  6. * Patients not currently eligible for an alternate competing interventional clinical trial
  7. * Enrollment in the Mayo Clinic Cancer Center Neuro-Oncology Program Registry for the study of Nervous System Tumors (IRB#12-003458)
  1. * Age \< 18 years
  2. * Found to be a member of a vulnerable population (e.g. pregnant, lacking capacity to consent) during the course of pre-enrollment or pre-surgical assessment
  3. * Prior gross total resection of brain tumor leading to absence of visible latent disease (exemption available for post-operative enrollment)
  4. * Any contraindication to surgery, including anyone who in the opinion of the surgeon is at unreasonably elevated risk of wound complications
  5. * Patients who have not yet undergone surgery or radiation, but who would be appropriate candidates for an alternate interventional clinical trial (e.g. post-operative fractionated vs single fraction radiation to the surgical cavity for surgical brain metastases)

Contacts and Locations

Principal Investigator

Terry C. Burns, MD, PhD
PRINCIPAL_INVESTIGATOR
Mayo Clinic in Rochester

Study Locations (Sites)

Mayo Clinic in Rochester
Rochester, Minnesota, 55905
United States

Collaborators and Investigators

Sponsor: Mayo Clinic

  • Terry C. Burns, MD, PhD, PRINCIPAL_INVESTIGATOR, Mayo Clinic in Rochester

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-05-06
Study Completion Date2028-03-01

Study Record Updates

Study Start Date2021-05-06
Study Completion Date2028-03-01

Terms related to this study

Additional Relevant MeSH Terms

  • Brain Neoplasm