RECRUITING

Cognition and Motor Learning Post-stroke

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.

Official Title

Cognition as a Moderator of Motor Learning Post-stroke

Quick Facts

Study Start:2023-01-16
Study Completion:2025-08-14
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04829071

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:45 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Unilateral stroke
  2. * Stroke occurred more than 6 months prior
  3. * Paresis confined to one side
  4. * Independently ambulatory (including the use of assistive devices)
  5. * Able to walk for 5 minutes without stopping
  6. * Answers no to all general health questions on the PAR-Q+
  7. * Willingness to complete study procedures
  1. * Brainstem or cerebellar stroke
  2. * Aphasia (expressive, receptive, or global)
  3. * Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function
  4. * Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations
  5. * Uncontrolled hypertension (\>160/110mmHg)
  6. * Concurrent physical therapy
  7. * Claustrophobia
  8. * Significant cognitive deficit or dementia (\<20 on MoCA)
  9. * Inability to give informed consent

Contacts and Locations

Study Contact

Kristan Leech, PT, DPT, PhD
CONTACT
(323) 442-1583
kleech@pt.usc.edu
Sarah Kettlety, MS
CONTACT
(323) 442-1196
kettlety@usc.edu

Principal Investigator

Kristan Leech, PT, DPT, PhD
PRINCIPAL_INVESTIGATOR
University of Southern California

Study Locations (Sites)

Center for Health Professions
Los Angeles, California, 90033
United States

Collaborators and Investigators

Sponsor: University of Southern California

  • Kristan Leech, PT, DPT, PhD, PRINCIPAL_INVESTIGATOR, University of Southern California

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-01-16
Study Completion Date2025-08-14

Study Record Updates

Study Start Date2023-01-16
Study Completion Date2025-08-14

Terms related to this study

Keywords Provided by Researchers

  • stroke
  • walking
  • rehabilitation
  • cognition

Additional Relevant MeSH Terms

  • Stroke
  • CVA (Cerebrovascular Accident)