Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- 1. Males and females within the ages of 18-85
- 2. Diagnosis of soft tissue sarcoma that has been histologically confirmed by an approved reference pathologist
- 3. Sarcoma of the upper or lower extremity location
- 4. Treatment plan that includes neo-adjuvant radiation therapy followed by surgical resection
- 5. Expected primary wound closure performed at the time at surgery
- 6. Any disease stage
- 7. Any tumor grade
- 8. Any histologic subtype
- 9. First or recurrent presentations
- 10. No vascular invasion or resection/repair/reconstruction that results in decreased perfusion of the extremity
- 11. No history of radiation therapy to the tumor and/or surgical area prior to the current treatment being studied
- 12. Must be able to comply with follow up visits
- 13. Must be able to provide own consent
- 1. Patients under the age of 18, or over the age of 85
- 2. Treatment plan that does not include neo-adjuvant radiation and surgical excision
- 3. Sarcoma location other than the upper or lower extremity
- 4. History of radiation therapy to the tumor and/or surgical area prior to the current treatment being studied
- 5. High dose steroid therapy (defined as \>5mg prednisone, or equivalent, with the last 30 days)
- 6. Active treatment with chemotherapy within the last 30 days
- 7. Inability of the patient to provide informed consent (i.e. dementia, cognitive impairment, non-English speakers)
- 8. Plan for post-operative radiation therapy
- 9. Underlying severe cardiopulmonary disease
- 10. Prior surgery, other than a biopsy, at the site of disease
- 11. Tumors that are ulcerative or fungating through the dermis at the time of presentation
- 12. Vascular invasion or resection/repair/reconstruction that results in decreased perfusion of the extremity
- 13. Vascular disease resulting in clinically apparent compromise in blood flow to the treatment extremity (i.e. peripheral vascular disease with diminished pulses, venous insufficiency with clinical evidence of vascular congestion)
- 14. Actively uncontrolled diabetes mellitus (documentation of history of Diabetes with A1c\>8)
- 15. Active deep vein thrombosis in the treatment extremity
- 16. Inability to comply with follow up visits
- 17. Pregnant females (women of childbearing potential must have a negative serum pregnancy test prior to enrollment)
Ages Eligible for Study
18 Years to 85 Years
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
No